Product image of Octoret (Gentamicin) supplied by GNH India

Octoret

Active Ingredient:
Gentamicin
Origin:
EU

Octoret (Gentamicin)

Gentamicin, the active ingredient in Octoret, is an aminoglycoside antibiotic presented as a 0.1% ophthalmic solution for topical ocular use. It treats bacterial eye infections such as conjunctivitis and keratitis in adults and children. GNH India supplies Octoret as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

GNH India supplies Octoret as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

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Indications & Clinical Uses

Gentamicin is an aminoglycoside that targets Gram‑negative and some Gram‑positive bacteria in ocular infections.

  • Bacterial conjunctivitis: reduces bacterial load and accelerates symptom relief.
  • Bacterial keratitis: helps eradicate the infecting organism and prevents corneal scarring.
  • Post‑operative ocular prophylaxis: lowers the risk of infection after eye surgery.

How It Works

  • Gentamicin binds to the 30S ribosomal subunit of susceptible bacteria, causing misreading of mRNA and inhibition of protein synthesis. This bactericidal action leads to rapid bacterial cell death, particularly against aerobic Gram‑negative organisms and some Gram‑positive strains.

Side Effects

Gentamicin ophthalmic solution may cause local and systemic adverse reactions.

Common Side Effects

  • Eye irritation: transient burning or stinging sensation.
  • Redness: mild conjunctival hyperemia.
  • Tearing: increased lacrimation.
  • Foreign‑body sensation: feeling of grit in the eye.
  • Blurred vision: temporary visual disturbance.

Serious or Rare Side Effects

  • Corneal ulceration: breakdown of corneal epithelium.
  • Hypersensitivity reaction: eyelid edema, rash, or pruritus.
  • Ototoxicity: rare systemic absorption leading to hearing changes.
  • Nephrotoxicity: rare systemic effect with prolonged use.
  • Anaphylaxis: severe allergic response requiring immediate medical attention.

Precautions & Warnings

Gentamicin ophthalmic solution should be used with caution in specific clinical situations.

  • Renal impairment: monitor for systemic absorption in prolonged therapy.
  • Auditory dysfunction: avoid prolonged use in patients with pre‑existing hearing loss.
  • Pregnancy: use only if clearly needed; weigh maternal benefit against potential fetal risk.
  • Pediatric use: limit duration in infants and young children.
  • Contact lens wearers: remove lenses before instillation and wait before reinserting.
  • Store at ambient temperature: keep in original container, protect from light and moisture.

Avoid Interactions

Gentamicin may interact with other medicines, altering efficacy or safety.

Major Interactions (Avoid)

  • Loop diuretics: increase risk of nephrotoxicity.
  • Other aminoglycosides: additive ototoxic and nephrotoxic effects.
  • Neuromuscular blocking agents: may potentiate neuromuscular blockade.

Moderate Interactions (Monitor Closely)

  • Vancomycin: combined use may increase renal toxicity.
  • NSAIDs: concurrent use may heighten nephrotoxic potential.
  • Radiographic contrast agents: monitor kidney function when used together.

Frequently Asked Questions

Octoret is a gentamicin‑containing ophthalmic solution indicated for the treatment of bacterial eye infections such as conjunctivitis and keratitis, and for prophylaxis after ocular surgery. It works by eliminating susceptible bacteria on the ocular surface.

Gentamicin binds to bacterial 30S ribosomal subunits, causing misreading of messenger RNA and halting protein synthesis. This bactericidal action rapidly kills susceptible Gram‑negative and some Gram‑positive organisms that cause eye infections.

The prescribed dosing regimen for Octoret is determined by the treating clinician based on infection severity, patient age and response to therapy. Healthcare professionals adjust the number of drops and frequency according to clinical guidelines.

Gentamicin eye drops are classified as pregnancy category B in many regions, indicating no proven risk in animal studies but limited human data. They should be used only if clearly needed, and breastfeeding mothers should consult a healthcare provider.

To order Octoret, submit an enquiry on the product page at gnhindia.com with the required quantity. GNH India supplies hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and import documentation.

Octoret (gentamicin) offers broad‑spectrum activity against Gram‑negative bacteria and some Gram‑positive strains, similar to other aminoglycoside drops like tobramycin. Compared with fluoroquinolone eye drops, gentamicin has a lower risk of developing resistance but may require more careful monitoring for renal or auditory toxicity.

Octoret should be stored at ambient temperature, below 25 °C, in its original container. Protect the solution from light and moisture, and discard any product that appears discolored or cloudy.

Octoret is applied topically to the eye as directed by a healthcare professional. Typically, one to two drops are placed in the affected eye(s) at the prescribed interval, ensuring the eyelid is gently closed after instillation to allow absorption.

Serious risks include corneal ulceration, hypersensitivity reactions such as eyelid edema or rash, and rare systemic effects like ototoxicity or nephrotoxicity, especially with prolonged use or excessive systemic absorption.

Patients with known hypersensitivity to gentamicin or other aminoglycosides should avoid Octoret. Caution is also advised for individuals with significant renal impairment, existing hearing loss, or those using contact lenses without proper removal before dosing.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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