Product image of Octostim (Desmopressin Acetate) supplied by GNH India

Octostim

Active Ingredient:
Desmopressin Acetate
Origin:
EU

Octostim (Desmopressin Acetate)

Desmopressin Acetate, the active ingredient in Octostim, is an antidiuretic hormone analog presented as a 0.1 mg oral tablet for systemic use. It helps control excessive urine production in conditions such as central diabetes insipidus and certain bleeding disorders. GNH India supplies Octostim as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals and pharmacies worldwide.

GNH India supplies Octostim as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals and pharmacies worldwide.

Manufacturer / TM Owner

Ferring Lægemidler A/S

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Indications & Clinical Uses

Octostim is an antidiuretic hormone analog that acts on the body's water‑balance pathways.

  • Central diabetes insipidus: reduces excessive thirst and urine output.
  • Nocturnal enuresis (bed‑wetting) in children: decreases nighttime urine production.
  • Mild hemophilia A or von Willebrand disease (pre‑surgical): raises plasma levels of factor VIII and von Willebrand factor to reduce bleeding risk.

How It Works

  • Desmopressin acetate mimics the action of the natural hormone vasopressin by selectively stimulating V2 receptors in the renal collecting ducts. This activation promotes the insertion of aquaporin‑2 water channels into the tubular membrane, enhancing water reabsorption, concentrating urine, and modestly increasing plasma levels of clotting factor VIII and von Willebrand factor.

Side Effects

Desmopressin may cause a range of adverse reactions, most of which are mild and reversible.

Common Side Effects

  • Headache: mild to moderate intensity.
  • Nasal irritation: dryness or mild burning if administered intranasally.
  • Nausea or upset stomach.
  • Hyponatraemia: low blood sodium, usually mild.
  • Flushing or warmth sensation.

Serious or Rare Side Effects

  • Severe hyponatraemia with seizures or coma.
  • Thromboembolic events such as deep‑vein thrombosis.
  • Allergic reactions: rash, itching, or anaphylaxis.
  • Cardiac arrhythmias linked to electrolyte shifts.
  • Acute pulmonary oedema in susceptible individuals.

Precautions & Warnings

Before using Octostim, consider the following safety points:

  • Assess renal function: impaired kidneys increase risk of fluid overload.
  • Monitor serum sodium: hyponatraemia can develop, especially with high fluid intake.
  • Review cardiovascular status: caution in patients with heart failure.
  • Evaluate bleeding risk: use cautiously in patients with known clotting disorders.
  • Store at ambient temperature: keep below 25°C, in the original container, protected from moisture.

Avoid Interactions

Desmopressin can interact with several medicines that affect fluid balance or haemostasis.

Major Interactions (Avoid)

  • Concomitant use of carbamazepine or other enzyme‑inducing antiepileptics: reduces desmopressin effectiveness.
  • NSAIDs (high‑dose ibuprofen, naproxen): increase risk of hyponatraemia.
  • Warfarin or other anticoagulants: may alter bleeding risk when desmopressin is used for haemostatic purposes.

Moderate Interactions (Monitor Closely)

  • Diuretics (especially thiazides): amplify water‑retention effects.
  • Selective serotonin reuptake inhibitors (SSRIs): modestly raise hyponatraemia risk.
  • ACE inhibitors or ARBs: additive effect on sodium balance.

Frequently Asked Questions

Octostim contains desmopressin acetate, which is prescribed for central diabetes insipidus, nocturnal enuresis in children, and as a short‑term haemostatic agent in mild hemophilia A or von Willebrand disease before surgery.

Desmopressin acetate acts as a synthetic analogue of vasopressin. It selectively binds to V2 receptors in the kidney’s collecting ducts, triggering aquaporin‑2 channel insertion and increasing water reabsorption, which concentrates urine and raises plasma levels of clotting factor VIII and von Willebrand factor.

The exact dose of Octostim is determined by the prescribing clinician based on the patient’s age, weight, indication and renal function. Dosage regimens are individualized and should follow the prescriber’s instructions.

Desmopressin is classified as pregnancy category B in many regions, indicating no proven risk in animal studies, but human data are limited. It should only be used during pregnancy or lactation if clearly needed and after a risk‑benefit assessment by the treating physician.

To request Octostim, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any required import documentation.

Octostim (desmopressin) is more selective for V2 receptors than older agents like vasopressin, resulting in fewer cardiovascular side effects. It also has a longer half‑life, allowing once‑ or twice‑daily dosing, and provides additional haemostatic benefits not seen with pure diuretics.

Octostim tablets should be stored at ambient temperature, below 25 °C, in the original packaging to protect from moisture and light. Do not store in areas with high humidity or extreme heat.

Octostim is supplied as an oral tablet that is swallowed whole with water. Depending on the indication, it may also be formulated for intranasal or injectable use, but the tablet form is taken by mouth as directed by the prescriber.

The most serious adverse events include severe hyponatraemia, which can lead to seizures or coma, and rare thromboembolic complications. Patients should be monitored for sudden changes in mental status, fluid retention, or signs of blood clots.

Octostim is contraindicated in patients with known hypersensitivity to desmopressin, uncontrolled hyponatraemia, severe renal impairment, or those with a history of thromboembolic disease unless the benefits outweigh the risks.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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