Product image of Octreoteva Long Acting (Octreotide Acetate) supplied by GNH India

Octreoteva Long Acting

Active Ingredient:
Octreotide Acetate
Origin:
EU

Octreoteva Long Acting (Octreotide Acetate)

Octreotide Acetate, the active ingredient in Octreoteva Long Acting, is a peptide hormone/somatostatin analog presented as a long‑acting injectable formulation for subcutaneous use. It is used to control hormone‑secreting tumors and related conditions.

GNH India supplies Octreoteva Long Acting as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, transplant centres and pharmacies worldwide.

Manufacturer / TM Owner

Teva B.V

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Indications & Clinical Uses

  • Octreoteva Long Acting is a somatostatin analog indicated for conditions driven by excess hormone secretion.
  • Acromegaly: reduces growth hormone levels and controls disease activity.
  • Carcinoid syndrome: decreases serotonin release and alleviates flushing and diarrhea.
  • VIPoma: suppresses vasoactive intestinal peptide secretion, reducing watery diarrhoea and electrolyte loss.

How It Works

  • Octreotide acetate binds with high affinity to somatostatin receptors (mainly subtypes sst2 and sst5) on endocrine and neuroendocrine cells, inhibiting adenylate cyclase activity and calcium influx. This suppresses the secretion of growth hormone, insulin, glucagon, serotonin, and vasoactive intestinal peptide, thereby reducing hormone‑driven clinical manifestations.

Side Effects

Octreoteva Long Acting may cause a range of adverse reactions.

Common Side Effects

  • Abdominal pain or discomfort
  • Nausea and vomiting
  • Diarrhoea or constipation
  • Injection‑site erythema or induration
  • Gallstone formation
  • Hyperglycaemia or altered glucose tolerance

Serious or Rare Side Effects

  • Severe bradycardia or cardiac arrhythmias
  • Acute pancreatitis
  • Anaphylactic or severe allergic reactions
  • Hepatic dysfunction or jaundice
  • Hypothyroidism or adrenal insufficiency
  • Thromboembolic events

Precautions & Warnings

  • Before initiating therapy, consider the following precautions.
  • Monitor blood glucose: adjust antidiabetic therapy as needed.
  • Assess gallbladder status: patients with gallstones may require monitoring.
  • Evaluate cardiac function: caution in patients with known conduction abnormalities.
  • Dose adjustment in hepatic or renal impairment: consider reduced dosing.
  • Avoid in known hypersensitivity to octreotide or formulation components.
  • Store at 2-8°C: keep refrigerated, protect from light, do not freeze or shake.

Avoid Interactions

Octreoteva Long Acting can interact with several medicines.

Major Interactions (Avoid)

  • Cyclosporine: may increase octreotide plasma concentrations.
  • Somatostatin analog combinations: additive hormonal suppression.
  • Quinidine: risk of QT prolongation may be heightened.

Moderate Interactions (Monitor Closely)

  • Oral contraceptives: reduced efficacy due to decreased enterohepatic recirculation.
  • Antidiabetic agents: altered glucose control may require dose adjustment.
  • Antiplatelet or anticoagulant drugs: potential for increased bleeding risk.

Frequently Asked Questions

Octreoteva Long Acting contains octreotide acetate, a somatostatin analog used to manage hormone‑secreting disorders such as acromegaly, carcinoid syndrome, and VIPoma. It helps control excess hormone production and related symptoms in these conditions.

Octreotide acetate binds to somatostatin receptors, primarily subtypes sst2 and sst5, on endocrine and neuroendocrine cells. This binding inhibits adenylate cyclase and calcium influx, reducing the secretion of hormones like growth hormone, serotonin, and vasoactive intestinal peptide, thereby mitigating disease activity.

The dosage of Octreoteva Long Acting is individualized by the prescribing clinician based on the specific indication, patient weight, disease severity, and response to therapy. Only a qualified healthcare professional should determine the appropriate dosing regimen.

Octreotide acetate is classified as pregnancy category B; animal studies have not shown risk, but there are limited human data. It should be used during pregnancy only if clearly needed. Breastfeeding is not recommended because the drug may be excreted in milk and could affect the infant.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India supplies hospitals, pharmacies, and procurement teams worldwide. After submission, the team will verify trade or institutional credentials and respond with pricing, availability, shipping details (including cold‑chain logistics if required), and import documentation.

Octreoteva Long Acting provides prolonged drug exposure with fewer injections compared with short‑acting octreotide formulations. Compared with lanreotide, another long‑acting analog, octreotide has a slightly broader receptor affinity profile, which may influence efficacy in certain neuroendocrine tumors. Choice of therapy depends on clinical response, patient preference, and physician judgment.

Octreoteva Long Acting must be stored refrigerated at 2‑8 °C. Keep the product in its original packaging, protect it from light, and avoid freezing or shaking. If the temperature rises above the recommended range, discard the product according to local regulations.

Octreoteva Long Acting is given by subcutaneous injection, typically by a healthcare professional. The injection site is rotated to minimize local reactions. The exact administration schedule—such as every 4 weeks—will be determined by the prescribing clinician based on the patient’s condition.

Serious adverse events include severe bradycardia, acute pancreatitis, anaphylactic reactions, hepatic dysfunction, and rare thromboembolic events. Patients should be monitored for signs of these conditions, and therapy should be discontinued if any serious reaction occurs.

Octreoteva Long Acting is contraindicated in patients with known hypersensitivity to octreotide acetate or any excipients in the formulation. Caution is also advised for individuals with severe cardiac conduction disorders, uncontrolled diabetes, or active gallbladder disease.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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