Product image of Octreotid Bendalis (Octreotide) supplied by GNH India

Octreotid Bendalis

Active Ingredient:
Octreotide
Origin:
EU

Octreotid Bendalis (Octreotide)

Octreotide, the active ingredient in Octreotid Bendalis, is a somatostatin analog presented as a sterile injectable solution for subcutaneous or intravenous use. It is employed to control hormone‑secreting tumors and related endocrine disorders.
GNH India supplies Octreotid Bendalis as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, transplant centres, oncology centres, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Bendalis Gmbh

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Indications & Clinical Uses

Octreotide acts on neuroendocrine pathways to regulate excessive hormone secretion.

  • Acromegaly: lowers growth hormone and IGF‑1 levels, helping to control disease activity.
  • Carcinoid syndrome: reduces flushing and diarrhea by inhibiting serotonin release.
  • VIPoma: controls severe watery diarrhea and electrolyte loss through vasoactive intestinal peptide suppression.
  • Neuroendocrine tumors: slows tumor‑related hormone production and may limit tumor growth.

How It Works

  • Octreotide mimics natural somatostatin and binds with high affinity to somatostatin receptor subtypes 2 and 5 on endocrine cells. This receptor activation inhibits adenylate cyclase, reduces intracellular calcium, and suppresses the release of growth hormone, insulin, glucagon, gastrin, vasoactive intestinal peptide, and other peptide hormones, thereby modulating neuroendocrine activity.

Side Effects

Octreotide may cause a range of adverse reactions.

Common Side Effects

  • Abdominal pain or discomfort
  • Nausea and vomiting
  • Diarrhea or constipation
  • Gallstone formation
  • Injection site erythema or bruising
  • Hyperglycemia or altered glucose tolerance

Serious or Rare Side Effects

  • Acute pancreatitis
  • Severe hypoglycemia, especially in diabetic patients
  • Cardiac arrhythmias or conduction disturbances
  • Anaphylactic or severe allergic reactions
  • Biliary colic or cholecystitis related to gallstones
  • Severe infection at injection site

Precautions & Warnings

Octreotide requires careful monitoring in several clinical situations.

  • Renal impairment: monitor renal function and adjust therapy as needed.
  • Gallbladder disease: assess for gallstone formation and biliary complications.
  • Diabetes mellitus: regularly check blood glucose levels for hyper‑ or hypoglycemia.
  • Pregnancy and lactation: use only if potential benefit justifies potential risk to fetus or infant.
  • Concomitant medications: review all drugs for possible interactions before initiating therapy.

Store at 2‑8 °C: keep refrigerated, protect from light, do not freeze or shake.

Avoid Interactions

Octreotide can influence or be influenced by other medicines.

Major Interactions (Avoid)

  • Cyclosporine: may increase octreotide plasma concentrations, raising risk of adverse effects.
  • Other somatostatin analogs: additive hormonal suppression can lead to severe hypoglycemia or gallbladder issues.

Moderate Interactions (Monitor Closely)

  • Insulin or oral hypoglycemics: octreotide may mask hypoglycemia symptoms; adjust glucose monitoring.
  • Diazoxide and glucagon: may reduce octreotide efficacy in controlling hormone excess.
  • Certain antibiotics (e.g., erythromycin): can alter gut flora and affect hormone metabolism, requiring observation.

Frequently Asked Questions

Octreotid Bendalis contains octreotide, a somatostatin analog that is used to manage hormone‑secreting disorders such as acromegaly, carcinoid syndrome, VIPoma, and certain neuroendocrine tumors. By inhibiting excess hormone release, it helps control symptoms and disease progression in these patients.

Octreotide mimics the natural hormone somatostatin and binds to somatostatin receptors, primarily subtypes 2 and 5, on endocrine cells. This binding blocks adenylate cyclase activity, reduces intracellular calcium, and suppresses the secretion of multiple hormones, including growth hormone, insulin, glucagon, and serotonin.

The specific dose and administration schedule for Octreotid Bendalis are determined by the prescribing clinician based on the patient’s condition, severity, and response to therapy. Healthcare professionals tailor the regimen to achieve optimal hormonal control while minimizing adverse effects.

Octreotid Bendalis should be used in pregnancy or while breastfeeding only if the potential benefit outweighs the possible risk to the fetus or infant. Clinicians evaluate each case individually, and patients are advised to discuss any concerns with their healthcare provider before starting therapy.

To request Octreotid Bendalis, submit an enquiry on the product page at gnhindia.com with the required quantity. GNH India supplies hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including cold‑chain if needed), and import documentation.

Octreotid Bendalis contains octreotide, which has a high affinity for somatostatin receptor subtypes 2 and 5, offering potent inhibition of hormone secretion. Compared with other analogs such as lanreotide, octreotide provides a well‑established efficacy profile for acute symptom control and is available in both short‑acting and long‑acting formulations.

Octreotid Bendalis should be stored refrigerated at 2 °C to 8 °C. Keep the product in its original packaging, protect it from light, and avoid freezing or shaking the vial. Proper cold‑chain handling ensures the stability and potency of the injectable solution.

Octreotid Bendalis is supplied as a sterile injectable solution for subcutaneous or intravenous injection. The route, injection site, and frequency are determined by the prescribing clinician, who will also provide instructions on preparation, dosing, and any necessary monitoring.

Serious risks include pancreatitis, severe hypoglycemia (especially in diabetic patients), cardiac arrhythmias, gallbladder complications such as cholecystitis, and rare anaphylactic reactions. Patients should be monitored closely for these events, and any sudden or severe symptoms should prompt immediate medical evaluation.

Octreotid Bendalis is contraindicated in patients with known hypersensitivity to octreotide or any of its excipients. Caution is also advised for individuals with severe hepatic impairment, uncontrolled diabetes, or active gallbladder disease, as these conditions may increase the risk of adverse effects.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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