Product image of Octreotid Hexal (Octreotide) supplied by GNH India

Octreotid Hexal

Active Ingredient:
Octreotide
Origin:
EU

Octreotid Hexal (Octreotide)

Octreotide, the active ingredient in Octreotid Hexal, is a somatostatin analog presented as a sterile solution for subcutaneous use. It is employed to control hormone excess in conditions such as acromegaly, carcinoid syndrome, VIPoma and other hormone‑secreting tumors in adult patients.

GNH India supplies Octreotid Hexal as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, transplant centres, oncology centres, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Hexal Ag

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Indications & Clinical Uses

Octreotide acts on somatostatin receptors to modulate hormone secretion in several endocrine disorders.

  • Acromegaly: reduces growth hormone and IGF‑1 levels, helping to control disease activity.
  • Carcinoid syndrome: diminishes flushing and diarrhea by inhibiting serotonin release.
  • VIPoma: alleviates watery diarrhea and electrolyte loss through VIP suppression.
  • Hormone‑secreting tumors: curbs excess hormone production, improving clinical symptoms.

How It Works

  • Octreotide is a synthetic analogue of the endogenous peptide hormone somatostatin. It binds with high affinity to somatostatin receptor subtypes (particularly sst2 and sst5) on target cells, inhibiting adenylate cyclase activity and reducing intracellular cAMP. This receptor engagement suppresses the secretion of several hormones and peptides, including growth hormone, insulin, glucagon, serotonin, and vasoactive intestinal peptide, thereby modulating the clinical manifestations of hormone‑dependent diseases.

Side Effects

Octreotide may be associated with a range of adverse reactions, most of which are dose‑related and reversible upon discontinuation.

Common Side Effects

  • Injection site pain or erythema.
  • Gastrointestinal disturbances such as nausea, abdominal pain, or constipation.
  • Gallbladder sludge or gallstones.
  • Hyperglycemia or hypoglycemia.
  • Headache.

Serious or Rare Side Effects

  • Severe hypersensitivity reactions, including anaphylaxis.
  • Pancreatitis.
  • Cardiac arrhythmias.
  • Severe hyperglycemia requiring medical intervention.
  • Acute cholecystitis.
  • Thromboembolic events.

Precautions & Warnings

Before initiating therapy, clinicians should evaluate patient history and monitor for potential complications.

  • Renal impairment: adjust monitoring as the drug is cleared renally.
  • Hepatic dysfunction: observe for altered metabolism and possible accumulation.
  • Diabetes mellitus: monitor blood glucose closely due to possible hyper‑ or hypoglycemia.
  • Gallbladder disease: assess risk of gallstone formation during long‑term use.
  • Pregnancy and lactation: use only if the potential benefit justifies the potential risk to the fetus or infant.
  • Store at 2-8°C: keep refrigerated, protect from light, do not freeze or shake.

Avoid Interactions

Octreotide can influence the pharmacokinetics or pharmacodynamics of several concomitant medicines.

Major Interactions (Avoid)

  • Cyclosporine: may increase cyclosporine levels, risking nephrotoxicity.
  • Octreotide and insulin secretagogues: can cause severe hypoglycemia.

Moderate Interactions (Monitor Closely)

  • Oral contraceptives: reduced efficacy due to altered hormone metabolism.
  • Somatostatin analogs combined with other hormone‑suppressing agents: monitor for additive effects.
  • Antidiabetic agents: adjust glucose monitoring as octreotide may mask hyperglycemia.

Frequently Asked Questions

Octreotid Hexal contains octreotide, a somatostatin analogue used to manage hormone‑excess disorders such as acromegaly, carcinoid syndrome, VIPoma and other hormone‑secreting tumors. By suppressing the release of specific hormones, it helps control symptoms and disease progression in these patients.

Octreotide mimics natural somatostatin and binds to somatostatin receptors, especially subtypes sst2 and sst5. This binding inhibits adenylate cyclase, reduces cAMP formation, and consequently decreases the secretion of several hormones and peptides, including growth hormone, serotonin, and vasoactive intestinal peptide.

The dosage of Octreotid Hexal is individualized. A qualified prescriber determines the appropriate amount, frequency, and duration based on the specific indication, patient characteristics, and clinical response. Patients should follow the prescribing information provided by their healthcare professional.

Safety data for octreotide in pregnancy and lactation are limited. It should only be used if the potential therapeutic benefit justifies any possible risk to the fetus or infant. Healthcare providers must assess the risk‑benefit profile for each patient before prescribing.

To request Octreotid Hexal, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including cold‑chain if needed) and necessary import documentation.

Octreotid Hexal contains octreotide, which shares the same mechanism as other somatostatin analogues like lanreotide. While both suppress hormone secretion, differences may exist in formulation, dosing frequency, and pharmacokinetic profiles. Choice of agent depends on clinical factors, patient preference, and physician judgment.

Octreotid Hexal should be stored at 2‑8 °C (refrigerated). Keep the product in its original packaging, protect it from light, and avoid freezing or shaking the vial. Do not use the medication if it has been exposed to temperatures outside this range.

Octreotid Hexal is supplied as a sterile solution for subcutaneous injection. The injection is typically given into the abdominal wall or thigh, following aseptic technique. Administration instructions, including injection site rotation and needle handling, are provided by the prescribing clinician.

Serious risks include severe hypersensitivity reactions (anaphylaxis), pancreatitis, gallbladder disease such as acute cholecystitis, significant hyperglycemia, and cardiac arrhythmias. Patients should be monitored closely for these events, and therapy should be discontinued if any serious adverse reaction occurs.

Octreotid Hexal is contraindicated in patients with known hypersensitivity to octreotide or any excipients in the formulation. Caution is advised for individuals with severe hepatic or renal impairment, uncontrolled diabetes, or active gallbladder disease. A prescriber should evaluate each patient’s medical history before initiating therapy.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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