Product image of Octreotide Sun (Octreotide) supplied by GNH India

Octreotide Sun

Active Ingredient:
Octreotide
Origin:
EU

Octreotide Sun (Octreotide)

Octreotide, the active ingredient in Octreotide Sun, is a somatostatin analog presented as an injectable formulation for intravenous and subcutaneous use. It helps regulate excessive hormone secretion associated with neuroendocrine tumors, acromegaly, and severe diarrhea caused by vasoactive intestinal peptide, providing symptom control in adult patients.

GNH India supplies Octreotide Sun as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, transplant centres, oncology centres, pharmacies and clinics worldwide. The company adheres to stringent quality standards and provides regulatory support for global distribution.

Manufacturer / TM Owner

Sun Pharmaceutical Industries Europe B.V.

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Indications & Clinical Uses

Octreotide is a somatostatin analog used to manage conditions involving excess hormone secretion.

  • Acromegaly: reduces growth hormone and IGF‑1 levels, controlling disease activity.
  • Carcinoid syndrome: decreases flushing and diarrhea by inhibiting serotonin release.
  • VIPoma: controls watery diarrhea and electrolyte loss through suppression of vasoactive intestinal peptide.
  • Post‑operative pancreatic fistula: lowers pancreatic secretions, aiding fistula closure.

How It Works

  • Octreotide binds with high affinity to somatostatin receptor subtypes 2 and 5 on target cells, inhibiting adenylate cyclase activity and reducing cyclic AMP formation. This receptor activation suppresses the secretion of several hormones—including growth hormone, insulin, glucagon, gastrin, serotonin, and vasoactive intestinal peptide—and diminishes splanchnic blood flow, leading to the therapeutic effects observed in hormone‑dependent disorders.

Side Effects

Octreotide may cause a range of adverse reactions, most of which are mild and reversible.

Common Side Effects

  • Injection site pain or erythema
  • Nausea or vomiting
  • Abdominal cramps or discomfort
  • Diarrhea
  • Hyperglycemia or altered glucose tolerance
  • Gallbladder sludge or biliary colic

Serious or Rare Side Effects

  • Acute pancreatitis
  • Severe hyperglycemia requiring insulin
  • Cardiac arrhythmias or bradycardia
  • Hypotension or circulatory collapse
  • Anaphylactic or severe allergic reactions
  • Hepatic dysfunction

Precautions & Warnings

When prescribing Octreotide, several safety considerations should be observed.

  • Glucose monitoring: assess blood sugar regularly as hyperglycemia may occur.
  • Gallbladder assessment: evaluate for gallstones before long‑term therapy.
  • Renal/hepatic function: adjust dosing in patients with significant impairment.
  • Pregnancy: avoid unless benefit outweighs potential risk to the fetus.
  • Hypersensitivity: discontinue if signs of allergic reaction develop.
  • Store at 2‑8 °C: keep refrigerated, protect from light, do not freeze or shake.

Avoid Interactions

Octreotide can interact with other medicines, affecting their efficacy or safety.

Major Interactions (Avoid)

  • Cyclosporine: octreotide may increase cyclosporine levels, raising toxicity risk.
  • Oral contraceptives: reduced absorption may diminish contraceptive effectiveness.
  • Insulin or oral hypoglycemics: enhanced glucose‑lowering effect may require dose adjustment.
  • Quinidine: increased quinidine concentrations can lead to cardiac toxicity.
  • Other somatostatin analogs: additive hormonal suppression may cause severe side effects.

Moderate Interactions (Monitor Closely)

  • Dopamine agonists: combined effect on prolactin may require monitoring.
  • Antidepressants affecting serotonin: potential for altered serotonin levels.
  • Gastro‑intestinal motility agents: overlapping effects on gut motility may need observation.

Frequently Asked Questions

Octreotide Sun is a somatostatin analog indicated for the medical management of hormone‑excess disorders such as acromegaly, carcinoid syndrome‑related flushing and diarrhea, and VIPoma‑induced watery diarrhea. It is also employed to reduce pancreatic secretions in patients with postoperative pancreatic fistula. Treatment is individualized and prescribed by a qualified healthcare professional.

Octreotide mimics natural somatostatin by binding primarily to somatostatin receptor subtypes 2 and 5 on endocrine and neuroendocrine cells. This binding inhibits adenylate cyclase, lowers cyclic AMP, and suppresses the release of several hormones—including growth hormone, serotonin, and vasoactive intestinal peptide—thereby reducing the clinical manifestations of hormone‑driven diseases.

The dosage of Octreotide Sun is individualized based on the specific indication, patient weight, renal and hepatic function, and clinical response. A qualified prescriber determines the appropriate dose, route (intravenous or subcutaneous), and titration schedule. No fixed regimen is provided here; dosing information must be obtained from the prescribing physician.

Data on Octreotide use during pregnancy and lactation are limited. Animal studies have shown adverse effects, and human experience is insufficient to confirm safety. Consequently, Octreotide should be used in pregnancy only if the potential benefit justifies the potential risk to the fetus, and breastfeeding is generally not recommended unless the benefit outweighs the risk.

To order Octreotide Sun, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India supplies hospitals, pharmacies, and procurement teams worldwide, and will request verification of trade or institutional credentials. After confirmation, the sales team provides pricing, availability, shipping details—including cold‑chain logistics if needed—and assists with import documentation.

Octreotide and lanreotide are both long‑acting somatostatin analogs used for similar hormone‑excess conditions. Octreotide is available in short‑acting injectable forms for rapid titration, whereas lanreotide is typically administered as a deep‑subcutaneous depot with longer dosing intervals. Choice between them depends on clinical factors such as required dosing frequency, patient preference, and specific regulatory approvals in a given region.

Octreotide Sun must be stored refrigerated at 2 °C to 8 °C. Keep the vials in their original packaging, protect them from light, and avoid freezing or shaking the solution. Once reconstituted, the product should be used within the time frame specified in the label and any unused portion discarded according to local regulations.

Octreotide Sun is supplied as a sterile powder for injection. After reconstitution with the appropriate diluent, it can be administered intravenously as a continuous infusion or subcutaneously as a bolus injection, depending on the clinical indication and prescriber’s instructions. Administration should be performed by trained healthcare personnel using aseptic technique.

Serious adverse events associated with Octreotide include acute pancreatitis, severe hyperglycemia that may require insulin therapy, gallstone formation or biliary colic, cardiac arrhythmias, hypotension, and anaphylactic reactions. Patients should be monitored for signs of abdominal pain, sudden changes in blood glucose, jaundice, or allergic symptoms, and medical attention should be sought promptly if they occur.

Octreotide is contraindicated in patients with known hypersensitivity to octreotide or any of its excipients. Caution is also advised in individuals with uncontrolled diabetes, severe hepatic impairment, or active gallbladder disease. Pregnant or breastfeeding women should only use the drug when the expected therapeutic benefit outweighs the potential risk to the fetus or infant.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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