Product image of Oculaphenicol D (Chloramphenicol, Dexamethasone) supplied by GNH India

Oculaphenicol D

Active Ingredient:
Chloramphenicol, Dexamethasone
Origin:
EU

Oculaphenicol D (Chloramphenicol, Dexamethasone)

Chloramphenicol, the active ingredient in Oculaphenicol D, is an antibiotic presented as an ophthalmic solution for topical eye use. It treats bacterial eye infections and reduces inflammation when combined with a corticosteroid. Dexamethasone, the second active ingredient, is a corticosteroid that provides anti‑inflammatory action in the same formulation.

GNH India supplies Oculaphenicol D as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Zwitter Pharmaceuticals Επε

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Indications & Clinical Uses

Oculaphenicol D is used for ocular conditions where bacterial infection and inflammation coexist.

  • Bacterial conjunctivitis: reduces bacterial load and alleviates redness and discharge.
  • Keratitis (bacterial): helps eradicate infection and limits corneal inflammation.
  • Post‑operative ocular inflammation: controls inflammation while preventing secondary bacterial infection.
  • Allergic or irritative conjunctivitis with suspected bacterial component: provides symptom relief and antimicrobial coverage.

How It Works

  • Chloramphenicol inhibits bacterial protein synthesis by binding to the 50S ribosomal subunit, preventing peptide chain elongation. Dexamethasone, a synthetic glucocorticoid, binds intracellular glucocorticoid receptors, modulating gene transcription to suppress pro‑inflammatory cytokines, reduce vascular permeability, and inhibit leukocyte migration. The combination delivers simultaneous antimicrobial and anti‑inflammatory effects at the ocular surface.

Side Effects

Oculaphenicol D may cause local ocular reactions and, rarely, systemic effects.

Common Side Effects

  • Burning or stinging sensation: mild discomfort upon instillation.
  • Redness or mild irritation: transient conjunctival hyperemia.
  • Blurred vision: temporary visual disturbance that resolves after blinking.
  • Tearing: increased lacrimation shortly after use.

Serious or Rare Side Effects

  • Allergic contact dermatitis: localized swelling, itching, or rash.
  • Secondary ocular infection: overgrowth of resistant organisms.
  • Elevated intra‑ocular pressure: possible with prolonged corticosteroid exposure.
  • Systemic toxicity: rare systemic absorption leading to bone marrow suppression (chloramphenicol).

Precautions & Warnings

Before using Oculaphenicol D, consider the following precautions:

  • Contraindication: known hypersensitivity to chloramphenicol, dexamethasone, or formulation excipients.
  • Caution in viral eye infections: corticosteroid component may worsen viral replication.
  • Use limited duration: prolonged use can increase risk of intra‑ocular pressure rise.
  • Monitor in diabetic patients: corticosteroids may affect glucose control.
  • Avoid in children under 2 years: risk of systemic chloramphenicol toxicity.
  • Store at room temperature: keep in original container, protect from light and moisture.

Avoid Interactions

Ocular drugs can interact with systemic or topical agents, affecting efficacy or safety.

Major Interactions (Avoid)

  • Systemic aminoglycosides: may increase risk of ototoxicity when combined with corticosteroids.
  • Systemic anticoagulants: corticosteroids can potentiate bleeding risk.

Moderate Interactions (Monitor Closely)

  • Other ophthalmic NSAIDs or steroids: additive anti‑inflammatory effect may raise intra‑ocular pressure.
  • Systemic CYP3A4 inducers: may reduce dexamethasone exposure.
  • Topical ocular antibiotics: overlapping antimicrobial spectrum may select resistant flora.

Frequently Asked Questions

Oculaphenicol D is an ophthalmic solution that combines chloramphenicol and dexamethasone to treat bacterial eye infections such as conjunctivitis or keratitis, and to reduce associated inflammation, including post‑surgical ocular inflammation.

Chloramphenicol inhibits bacterial protein synthesis by binding to the 50S ribosomal subunit, preventing peptide chain formation and thereby stopping bacterial growth on the ocular surface.

The dosing regimen for Oculaphenicol D is determined by the prescribing clinician based on the specific ocular condition, severity, and patient factors. No standard dose is provided here.

Safety data are limited; chloramphenicol carries a risk of bone‑marrow suppression, and dexamethasone may affect fetal development. Use only if the potential benefit outweighs the risk and under medical supervision.

Enquire on the product page at gnhindia.com, entering the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, confirming trade or institutional credentials before providing pricing, availability, shipping details and import documentation.

Unlike single‑agent antibiotics, Oculaphenicol D adds dexamethasone for anti‑inflammatory action, offering both antimicrobial and steroid effects. This can be advantageous in mixed infection‑inflammation scenarios, but may require closer monitoring for steroid‑related side effects.

Store the ophthalmic solution at room temperature, away from direct sunlight and moisture. Keep the vial tightly closed and retain it in its original packaging until use.

The solution is applied topically to the affected eye(s) as directed by a healthcare professional, typically using a dropper to place the prescribed number of drops at the prescribed interval.

Serious risks include allergic reactions such as contact dermatitis, secondary ocular infections due to resistant organisms, elevated intra‑ocular pressure from the steroid component, and rare systemic chloramphenicol toxicity affecting bone‑marrow function.

Patients with known hypersensitivity to chloramphenicol, dexamethasone, or any excipients, as well as children under two years of age, should avoid this product. It is also contraindicated in viral eye infections without bacterial involvement.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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