Product image of Odrik (Trandolapril) supplied by GNH India

Odrik

Active Ingredient:
Trandolapril
Origin:
EU

Odrik (Trandolapril)

Trandolapril, the active ingredient in Odrik, is an ACE (Angiotensin-Converting Enzyme) Inhibitor presented as a tablet for oral use. It is employed in the management of hypertension and certain cardiac conditions in adult patients. GNH India supplies Odrik as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

GNH India supplies Odrik as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Viatris Healthcare Limited

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Indications & Clinical Uses

Trandolapril is an ACE inhibitor that acts on the renin‑angiotensin‑aldosterone system to lower blood pressure and protect the heart.

  • Hypertension: helps achieve target blood pressure levels and reduces cardiovascular risk.
  • Chronic heart failure: improves symptoms and decreases hospitalisation rates.
  • Post‑myocardial infarction: aids ventricular remodeling prevention and supports long‑term survival.

How It Works

  • Trandolapril is a pro‑drug that is converted to its active metabolite, trandolaprilat, which binds to and inhibits angiotensin‑converting enzyme. This blockade reduces the formation of angiotensin II, leading to vasodilation, decreased aldosterone secretion, and lowered systemic vascular resistance, thereby lowering blood pressure and reducing cardiac workload.

Side Effects

Adverse reactions to trandolapril may vary in frequency and severity.

Common Side Effects

  • Cough: dry, persistent throat irritation.
  • Dizziness: especially upon standing quickly.
  • Headache: mild to moderate intensity.
  • Fatigue: general feeling of tiredness.
  • Hyperkalemia: elevated blood potassium levels.
  • Renal function changes: modest rise in serum creatinine.

Serious or Rare Side Effects

  • Angioedema: swelling of face, lips, tongue or airway.
  • Severe hypotension: marked drop in blood pressure causing faintness.
  • Acute renal failure: rapid decline in kidney function.
  • Hepatic injury: elevated liver enzymes or hepatitis.
  • Neutropenia: low white‑blood‑cell count.
  • Anaphylaxis: life‑threatening allergic reaction.

Precautions & Warnings

When prescribing trandolapril, clinicians should consider several safety aspects.

  • Renal impairment: monitor serum creatinine and adjust dose if needed.
  • Hyperkalemia risk: check potassium levels regularly.
  • Pregnancy: contraindicated in the second and third trimesters.
  • Concomitant diuretics: may enhance blood‑pressure lowering effect.
  • Elderly patients: start with lower dose and titrate cautiously.
  • Store at below 25°C: keep in the original container, protect from moisture and light.

Avoid Interactions

Trandolapril may interact with other medicines, requiring vigilance.

Major Interactions (Avoid)

  • Aliskiren: combined use can cause excessive hypotension and renal dysfunction.
  • Potassium‑sparing diuretics: increase risk of hyper‑kalemia.
  • NSAIDs: may blunt antihypertensive effect and worsen renal function.

Moderate Interactions (Monitor Closely)

  • Lithium: ACE inhibition can raise lithium levels, risking toxicity.
  • Other antihypertensives: additive blood‑pressure lowering may require dose adjustment.
  • Antacids/chelating agents: may reduce absorption of trandolapril.

Frequently Asked Questions

Odrik contains trandolapril, an ACE inhibitor that is prescribed to lower high blood pressure, treat chronic heart failure and support patients after a myocardial infarction. It works by relaxing blood vessels, which helps reduce the workload on the heart and lowers the risk of cardiovascular events.

Trandolapril is a pro‑drug that is converted in the body to trandolaprilat, which blocks the angiotensin‑converting enzyme. This inhibition prevents the formation of angiotensin II, a potent vasoconstrictor, leading to vasodilation, reduced aldosterone release, lower blood pressure and decreased strain on the heart.

The appropriate dose of Odrik is determined by the prescribing clinician based on the individual’s medical condition, response to therapy and kidney function. Dosage adjustments are made during treatment to achieve target blood‑pressure goals while minimizing side effects.

Trandolapril is contraindicated in the second and third trimesters of pregnancy because it can harm the developing fetus. Limited data are available for breastfeeding; therefore, use is generally discouraged unless the potential benefit justifies the possible risk to the infant.

To order Odrik, submit an enquiry on the product page at gnhindia.com indicating the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Odrik (trandolapril) is similar in efficacy to other ACE inhibitors such as enalapril or lisinopril, but it has a longer half‑life and may be dosed once daily. Its side‑effect profile is comparable, with cough and hyper‑kalemia being the most common adverse events.

Store Odrik tablets at temperatures below 25 °C in the original packaging, protecting them from moisture and direct light. Keep the container tightly closed and out of reach of children.

Odrik is supplied as oral tablets that are taken whole with a glass of water. It can be taken with or without food, but patients should follow the prescribing clinician’s instructions regarding timing and any dose‑spacing with other medications.

The most serious risks include angioedema, severe hypotension, acute kidney injury and hyper‑kalemia. Patients should seek immediate medical attention if they experience swelling of the face or throat, fainting, sudden loss of kidney function or markedly elevated potassium levels.

Odrik should not be used by individuals with a known hypersensitivity to trandolapril or other ACE inhibitors, those with a history of angioedema related to ACE‑inhibitor therapy, and pregnant women in the second or third trimester. Caution is also advised for patients with severe renal impairment.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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