Product image of Odrinol (Disodium Phosphate Dodecahydrate, Sodium Dihydrogen Phosphate Dihydrate) supplied by GNH India

Odrinol

Active Ingredient:
Disodium Phosphate Dodecahydrate, Sodium Dihydrogen Phosphate Dihydrate
Origin:
EU

Odrinol (Disodium Phosphate Dodecahydrate, Sodium Dihydrogen Phosphate Dihydrate)

Disodium Phosphate Dodecahydrate, the active ingredient in Odrinol, is a mineral salt presented as an oral formulation for systemic use. It is used to correct electrolyte imbalances and support metabolic functions in clinical settings.

GNH India supplies Odrinol as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Viofar Ltd

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Indications & Clinical Uses

Odrinol is employed in medical practice to manage conditions related to phosphate balance and metabolic regulation:

  • Hypophosphatemia: helps restore normal serum phosphate levels.
  • Metabolic acidosis associated with renal failure: contributes to buffering capacity.
  • Preparation for certain diagnostic imaging procedures that require phosphate loading.
  • Adjunctive therapy during renal replacement therapy to maintain electrolyte homeostasis.
  • Supportive care in intensive care units for patients with severe electrolyte disturbances.

How It Works

  • Disodium phosphate dodecahydrate dissociates in aqueous solution to release phosphate ions, which participate in buffering physiological pH and serve as substrates for cellular energy metabolism. The administered phosphate increases serum inorganic phosphate, aiding in the correction of hypophosphatemia and supporting biochemical pathways that depend on phosphate availability.

Side Effects

Phosphate salts are generally well tolerated, but adverse reactions can occur.

Common Side Effects

  • Nausea: mild gastrointestinal discomfort.
  • Vomiting: occasional expulsion of stomach contents.
  • Diarrhea: loose stools may develop.
  • Abdominal pain: cramping or discomfort in the stomach area.
  • Hyperphosphatemia: elevated serum phosphate if overdosed.

Serious or Rare Side Effects

  • Hypocalcemia: low calcium levels secondary to phosphate binding.
  • Metabolic alkalosis: shift in acid‑base balance.
  • Allergic reaction: rash, itching, or swelling.
  • Renal impairment worsening: excess phosphate load may stress kidneys.
  • Severe electrolyte disturbances: potentially life‑threatening imbalances.

Precautions & Warnings

When using Odrinol, consider the following safety measures:

  • Dose adjustment: tailor dosing for patients with renal insufficiency.
  • Monitor electrolytes: regularly check serum phosphate, calcium, and magnesium.
  • Fluid balance: assess patient hydration status to avoid overload.
  • Concomitant medications: review other phosphate‑containing products.
  • Pregnancy and lactation: use only if clearly needed; limited data are available.
  • Store at below 25°C: keep in the original container, protect from moisture and direct sunlight.

Avoid Interactions

Phosphate salts can interact with several medicines, altering absorption or electrolyte balance.

Major Interactions (Avoid)

  • Calcium supplements: may precipitate calcium phosphate and reduce absorption.
  • Iron salts: can form insoluble complexes, decreasing bioavailability.

Moderate Interactions (Monitor Closely)

  • Bisphosphonates: concurrent use may affect phosphate homeostasis.
  • Antacids containing aluminum or magnesium: may interfere with phosphate uptake.
  • Loop diuretics: increase renal phosphate loss, requiring closer monitoring.
  • Vitamin D analogues: influence calcium‑phosphate metabolism.
  • Certain antibiotics (e.g., tetracyclines): may chelate with phosphate.

Frequently Asked Questions

Odrinol contains disodium phosphate dodecahydrate and is used primarily to correct low serum phosphate levels, support acid‑base balance in renal failure, and provide phosphate loading for certain diagnostic procedures. It is administered under medical supervision in hospitals or clinics.

The compound dissociates to release inorganic phosphate ions, which raise serum phosphate concentrations and act as a buffer in the body’s pH regulation system. This helps restore normal electrolyte balance and supports metabolic pathways that require phosphate.

The dosage of Odrinol is individualized by the prescribing clinician based on the patient’s serum phosphate level, renal function, and overall clinical condition. Healthcare professionals determine the appropriate amount and frequency for each case.

Safety data for Odrinol in pregnancy and lactation are limited. It should only be used when the potential benefit justifies any possible risk to the fetus or infant, and the decision must be made by a qualified healthcare provider.

To request Odrinol, submit an enquiry on the product page at gnhindia.com with the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Odrinol provides disodium phosphate dodecahydrate, a highly soluble phosphate salt that can be administered orally or intravenously. Compared with potassium phosphate or sodium phosphate monobasic forms, it offers a predictable phosphate load with minimal potassium content, which may be advantageous in patients requiring potassium restriction.

Store Odrinol at temperatures below 25 °C, in its original packaging, protected from moisture and direct sunlight. Maintaining these conditions helps preserve the stability and potency of the phosphate formulation.

Odrinol is supplied as an oral preparation and is taken by mouth according to the prescribing clinician’s instructions. It may be given with water or mixed into a suitable liquid, depending on patient preference and tolerability.

Serious risks include hyperphosphatemia, which can lead to calcium‑phosphate precipitation, hypocalcemia, metabolic alkalosis, and worsening renal function. Prompt monitoring of electrolyte levels is essential to detect and manage these complications.

Patients with severe hyperphosphatemia, uncontrolled hypercalcemia, or known hypersensitivity to phosphate salts should avoid Odrinol. Additionally, individuals with advanced renal failure who cannot safely excrete excess phosphate require careful assessment before use.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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