Product image of Odyral (Dorzolamide) supplied by GNH India

Odyral

Active Ingredient:
Dorzolamide
Origin:
EU

Odyral (Dorzolamide)

Dorzolamide, the active ingredient in Odyral, is a carbonic anhydrase inhibitor presented as a topical ophthalmic solution for ocular use. It lowers intra‑ocular pressure and is employed in the management of various forms of glaucoma and ocular hypertension.

GNH India supplies Odyral as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Uni-Pharma Kleon Tsetis Pharmaceutical Laboratories S.A.

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Indications & Clinical Uses

Dorzolamide acts on the aqueous humor production pathway and is indicated for several pressure‑related eye conditions.

  • Primary open‑angle glaucoma: reduces intra‑ocular pressure to slow disease progression.
  • Ocular hypertension: lowers eye pressure to prevent conversion to glaucoma.
  • Secondary glaucoma (e.g., pseudoexfoliative): assists in controlling pressure when other therapies are insufficient.

How It Works

  • Dorzolamide inhibits carbonic anhydrase enzymes in the ciliary body, decreasing bicarbonate formation and reducing aqueous humor secretion. The resulting decline in fluid production lowers intra‑ocular pressure, helping to protect the optic nerve from pressure‑related damage.

Side Effects

Adverse reactions may occur with any ophthalmic carbonic anhydrase inhibitor.

Common Side Effects

  • Burning or stinging sensation at the instillation site.
  • Transient blurred vision.
  • Taste disturbance (bitter taste).
  • Conjunctival hyperemia.
  • Mild ocular discomfort.
  • Dry eye sensation.

Serious or Rare Side Effects

  • Severe allergic reaction (angioedema, anaphylaxis).
  • Persistent corneal edema.
  • Significant visual acuity loss.
  • Iridocyclitis.
  • Stevens‑Johnson syndrome.
  • Toxic epidermal necrolysis.

Precautions & Warnings

Before using Dorzolamide‑containing eye drops, consider the following safety measures.

  • Allergy assessment: avoid if known hypersensitivity to dorzolamide or sulfonamides.
  • Ocular surgery: inform surgeon of use prior to any procedure.
  • Systemic sulfonamide use: monitor for cross‑reactivity.
  • Renal impairment: use with caution and under medical supervision.
  • Pregnancy and lactation: discuss risks with a healthcare professional.
  • Store at room temperature: keep in the original container, protect from light and moisture.

Avoid Interactions

Dorzolamide may interact with other medications affecting ocular pressure or systemic sulfonamide pathways.

Major Interactions (Avoid)

  • Systemic carbonic anhydrase inhibitors (e.g., acetazolamide): additive intra‑ocular pressure reduction.
  • Sulfonamide antibiotics (e.g., sulfamethoxazole): increased risk of hypersensitivity.

Moderate Interactions (Monitor Closely)

  • Topical beta‑blockers: potential for excessive pressure lowering.
  • Non‑steroidal anti‑inflammatory eye drops: may alter ocular surface tolerance.
  • Anticholinergic agents: possible reduction in tear production.

Frequently Asked Questions

Odyral contains dorzolamide, a carbonic anhydrase inhibitor used to lower intra‑ocular pressure in conditions such as primary open‑angle glaucoma, ocular hypertension, and certain secondary glaucomas.

Dorzolamide blocks carbonic anhydrase enzymes in the eye’s ciliary body, reducing bicarbonate production and decreasing aqueous humor secretion, which in turn lowers intra‑ocular pressure.

The dosing regimen for Odyral is determined by the prescribing clinician based on the patient’s condition, response, and tolerance. Patients should follow the specific instructions provided by their eye‑care professional.

Safety of dorzolamide in pregnancy or lactation has not been fully established. Women who are pregnant, planning pregnancy, or breastfeeding should discuss potential risks and benefits with their healthcare provider.

Enquiries can be submitted on the product page at gnhindia.com, specifying the required quantity. GNH India supplies hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Odyral (dorzolamide) belongs to the carbonic anhydrase inhibitor class, which lowers pressure by reducing aqueous humor production. It can be used alone or in combination with prostaglandin analogues or beta‑blockers, offering an alternative mechanism to agents that increase outflow.

Store Odyral at room temperature, below 25 °C, in the original packaging. Keep the container tightly closed, protect it from moisture and direct sunlight to maintain product stability.

Odyral is applied as an ophthalmic solution. The patient instills the prescribed number of drops into the affected eye(s) as directed by the eye‑care professional, typically one drop per eye at the recommended frequency.

Serious adverse events, though rare, include severe allergic reactions such as angioedema or anaphylaxis, corneal edema, and significant visual loss. Immediate medical attention is required if any of these symptoms develop.

Individuals with known hypersensitivity to dorzolamide, other sulfonamides, or any component of the formulation should avoid using Odyral. Patients with severe renal impairment should also consult their physician before use.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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