Product image of Odyral (Dorzolamide) supplied by GNH India

Odyral

Active Ingredient:
Dorzolamide
Origin:
EU

Odyral (Dorzolamide)

Dorzolamide, the active ingredient in Odyral, is a carbonic anhydrase inhibitor presented as a topical ophthalmic solution for ocular use. It is employed to lower intra‑ocular pressure in various forms of glaucoma and ocular hypertension.
GNH India supplies Odyral as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Uni-Pharma Kleon Tsetis Pharmaceutical Laboratories S.A.

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Indications & Clinical Uses

Dorzolamide acts on the ocular fluid‑production pathway to manage elevated intra‑ocular pressure.

  • Primary open‑angle glaucoma: reduces intra‑ocular pressure to slow disease progression.
  • Ocular hypertension: lowers pressure to prevent conversion to glaucoma.
  • Secondary glaucoma (e.g., pseudoexfoliative): helps control pressure when other agents are insufficient.

How It Works

  • Dorzolamide selectively inhibits carbonic anhydrase II in the ciliary body epithelium, decreasing aqueous humor formation. The reduced fluid production leads to lower intra‑ocular pressure, helping to prevent optic nerve damage associated with glaucoma.

Side Effects

Adverse reactions may occur with ocular administration of dorzolamide.

Common Side Effects

  • Burning or stinging sensation in the eye
  • Transient blurred vision
  • Altered taste sensation
  • Headache
  • Ocular discomfort or redness
  • Mild eye irritation

Serious or Rare Side Effects

  • Severe allergic reaction (e.g., angio‑edema, anaphylaxis)
  • Stevens‑Johnson syndrome or toxic epidermal necrolysis
  • Corneal edema or ulceration
  • Persistent ocular inflammation
  • Systemic metabolic acidosis (rare)
  • Vision loss due to severe ocular complications

Precautions & Warnings

When using dorzolamide, certain precautions should be observed.

  • Assess intra‑ocular pressure regularly: ensure therapeutic effectiveness.
  • Monitor for signs of hypersensitivity: discontinue if severe reaction occurs.
  • Use with caution in patients with sulfonamide allergy: cross‑reactivity possible.
  • Avoid contact lens wear during treatment: may cause lens discoloration or irritation.
  • Evaluate renal and hepatic function: dose adjustment may be required in impairment.
  • Store at room temperature: keep in the original container, protect from moisture and direct sunlight.

Avoid Interactions

Dorzolamide may interact with other ocular or systemic agents.

Major Interactions (Avoid)

  • Systemic carbonic anhydrase inhibitors (e.g., acetazolamide): increased risk of systemic acidosis.
  • Sulfonamide antibiotics (e.g., sulfamethoxazole): heightened hypersensitivity potential.

Moderate Interactions (Monitor Closely)

  • Topical beta‑blockers (e.g., timolol): additive intra‑ocular pressure reduction may require monitoring.
  • Prostaglandin analogues (e.g., latanoprost): combined effect may enhance pressure lowering.
  • Non‑steroidal anti‑inflammatory eye drops: may increase ocular irritation.
  • Systemic diuretics: possible electrolyte disturbances when combined.

Frequently Asked Questions

Odyral contains dorzolamide, a carbonic anhydrase inhibitor indicated for reducing intra‑ocular pressure in patients with primary open‑angle glaucoma, ocular hypertension, and certain secondary glaucomas. It may be used alone or in combination with other pressure‑lowering agents to help preserve visual function.

Dorzolamide blocks the activity of carbonic anhydrase II in the ciliary body, which reduces the production of aqueous humor. The resulting decrease in fluid volume lowers intra‑ocular pressure, thereby mitigating the risk of optic nerve damage associated with glaucoma.

The dosing schedule is determined by the prescribing ophthalmologist. Typically, one drop is instilled in each affected eye one to three times daily, but the exact frequency and duration are individualized based on the patient’s response and clinical judgment.

Dorzolamide is classified as pregnancy category C, meaning animal studies have shown risk and there are no adequate human studies. It should be used only if the potential benefit justifies the potential risk to the fetus. The drug can be excreted in breast milk, so nursing mothers should consult their healthcare provider before use.

To place an order, submit an enquiry on the Odyral product page at gnhindia.com, specifying the required quantity. GNH India supplies hospitals, pharmacies, and procurement teams worldwide. After the request, the sales team will verify trade or institutional credentials, then provide pricing, availability, shipping details (including any cold‑chain requirements), and necessary import documentation.

Odyral (dorzolamide) belongs to the carbonic anhydrase inhibitor class, offering a mechanism distinct from beta‑blockers (e.g., timolol) or prostaglandin analogues (e.g., latanoprost). Compared with brinzolamide, another CAI, dorzolamide has a similar efficacy profile but may differ in tolerability for some patients. Choice of therapy depends on individual response, side‑effect profile, and physician preference.

Odyral should be stored at room temperature, preferably below 25 °C. Keep the bottle in its original packaging, protect it from moisture and direct sunlight, and ensure the cap is tightly closed to maintain sterility and potency.

Odyral is applied as an ophthalmic solution. The patient should wash hands, tilt the head back, pull down the lower eyelid, and instill one drop into the conjunctival sac of each prescribed eye. Avoid touching the tip of the bottle to the eye or any surface to prevent contamination.

The most serious adverse events include severe allergic reactions such as angio‑edema or anaphylaxis, Stevens‑Johnson syndrome, corneal edema, and rare cases of systemic metabolic acidosis. Patients should seek immediate medical attention if they experience swelling of the face, lips, tongue, or eyes, skin blistering, or sudden vision changes.

Odyral is contraindicated in patients with a known hypersensitivity to dorzolamide, sulfonamides, or any component of the formulation. It should also be avoided in individuals with severe renal or hepatic impairment unless specifically advised by a physician, and in patients who wear contact lenses during treatment unless the lenses are removed before each dose.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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