Product image of Odyral (Dorzolamide) supplied by GNH India

Odyral

Active Ingredient:
Dorzolamide
Origin:
EU

Odyral (Dorzolamide)

Dorzolamide, the active ingredient in Odyral, is a carbonic anhydrase inhibitor presented as sterile ophthalmic eye drops for topical ocular use. It reduces aqueous humor production, thereby lowering intra‑ocular pressure in patients diagnosed with open‑angle glaucoma and ocular hypertension.

GNH India supplies Odyral as a licensed, GDP‑compliant international pharmaceutical supplier, providing the product to hospitals, pharmacies, and clinics across global markets while adhering to stringent quality and regulatory standards, and ensuring reliable delivery and post‑market support through its established distribution network.

Manufacturer / TM Owner

Orifarm Healthcare A/S

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Indications & Clinical Uses

Odyral (dorzolamide) is used in the management of ocular conditions that involve elevated intra‑ocular pressure.

  • Open‑angle glaucoma: reduces intra‑ocular pressure to slow disease progression.
  • Ocular hypertension: lowers eye pressure to prevent development of glaucoma.
  • Secondary glaucoma: helps control pressure when caused by other ocular diseases or trauma.

How It Works

  • Dorzolamide inhibits the enzyme carbonic anhydrase located in the ciliary body epithelium of the eye. By blocking this enzyme, the conversion of carbon dioxide and water to bicarbonate ions is reduced, leading to decreased aqueous humor formation. The resulting reduction in fluid volume lowers intra‑ocular pressure, which is the primary therapeutic goal in glaucoma and ocular hypertension for patients requiring long‑term pressure control.

Side Effects

Adverse reactions to dorzolamide eye drops may vary in frequency and severity.

Common Side Effects

  • Burning or stinging sensation in the eye.
  • Temporary blurred vision.
  • Taste disturbance (metallic taste).
  • Redness of the conjunctiva.

Serious or Rare Side Effects

  • Severe allergic reaction (angioedema, swelling of eyelids).
  • Persistent ocular pain.
  • Vision loss.
  • Stevens‑Johnson syndrome.

Precautions & Warnings

When using Odyral, follow these safety measures:

  • Use only as prescribed: follow ophthalmologist instructions for dosing frequency.
  • Avoid contact with other eyes: do not share the bottle.
  • Monitor intra‑ocular pressure: regular check‑ups are required.
  • Discontinue if severe irritation occurs: seek medical advice promptly.
  • Store at room temperature: keep in original container, protect from light and moisture.

Avoid Interactions

Dorzolamide may interact with other medications; consider the following:

Major Interactions (Avoid)

  • Systemic carbonic anhydrase inhibitors (e.g., acetazolamide): may increase risk of systemic side effects.
  • Topical ocular anesthetics: can enhance corneal toxicity.

Moderate Interactions (Monitor Closely)

  • Non‑steroidal anti‑inflammatory eye drops: may increase ocular irritation.
  • Beta‑blocker eye drops: additive intra‑ocular pressure lowering effect.
  • Anticholinergic agents: potential for reduced tear production.

Frequently Asked Questions

Odyral contains dorzolamide, indicated for management of elevated intra‑ocular pressure in conditions such as open‑angle glaucoma and ocular hypertension. The medication is administered as topical eye drops and is part of a comprehensive glaucoma treatment regimen that may include other agents or laser therapy.

Dorzolamide inhibits carbonic anhydrase in the ciliary body, decreasing the production of aqueous humor. This reduction in fluid formation lowers intra‑ocular pressure, which helps to protect the optic nerve from pressure‑related damage in glaucoma and ocular hypertension.

The dosing schedule for Odyral is determined by the prescribing ophthalmologist based on the patient’s condition, severity, and response to therapy. Typically, one drop is instilled in the affected eye(s) one to three times daily, but the exact regimen must be individualized.

Safety data for dorzolamide in pregnancy and lactation are limited. The medication should only be used if the potential benefit justifies any possible risk to the fetus or infant, and the decision should be made by a qualified healthcare professional.

To request Odyral, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Odyral (dorzolamide) belongs to the carbonic anhydrase inhibitor class, which lowers intra‑ocular pressure by reducing aqueous humor production. This mechanism differs from beta‑blockers that decrease fluid production via adrenergic blockade, and from prostaglandin analogues that increase outflow. Choice of therapy depends on efficacy, tolerability, patient comorbidities and physician preference.

Store Odyral eye drops at room temperature, below 25 °C, in the original container. Keep the bottle tightly closed, protect it from light and moisture, and do not freeze. Do not use the product after the expiration date printed on the label.

Odyral is applied as a sterile ophthalmic solution. The patient should wash hands, tilt the head back, pull down the lower eyelid, and place a single drop into the conjunctival sac of the affected eye(s). Close the eye gently and avoid blinking excessively for a few seconds to allow absorption.

Although uncommon, serious adverse reactions can include severe allergic responses such as angioedema or Stevens‑Johnson syndrome, persistent ocular pain, and sudden loss of vision. Patients should seek immediate medical attention if they experience swelling of the eyelids, rash, or any rapid deterioration in visual acuity.

Odyral is contraindicated in individuals with known hypersensitivity to dorzolamide, any carbonic anhydrase inhibitor, or any component of the formulation. It should also be avoided in patients with severe sulfonamide allergy, as cross‑reactivity may occur. Consultation with an eye care professional is essential before initiating therapy.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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