Product image of Oedien (Dienogest, Ethinylestradiol | Lactose Monohydrate) supplied by GNH India

Oedien

Active Ingredient:
Dienogest, Ethinylestradiol | Lactose Monohydrate
Origin:
EU

Oedien (Dienogest, Ethinylestradiol | Lactose Monohydrate)

Dienogest, the active ingredient in Oedien, is a synthetic progestogen presented as a combined oral tablet for systemic hormonal use. It treats estrogen‑dependent conditions, primarily menstrual‑related disorders, in women of reproductive age.

GNH India supplies Oedien as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Laboratoires Bailleul S.A.

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Indications & Clinical Uses

Oedien combines dienogest with ethinylestradiol to manage hormone‑responsive conditions. It is indicated for:

  • Dysmenorrhea: reduction of painful menstrual cramps.
  • Endometriosis‑associated pain: alleviation of chronic pelvic discomfort.
  • Contraception: prevention of ovulation and pregnancy when used as a combined oral contraceptive.

How It Works

  • Dienogest binds selectively to progesterone receptors, exerting anti‑ovulatory and anti‑proliferative effects on endometrial tissue, while ethinylestradiol provides estrogenic support that stabilises the endometrium and suppresses follicular development. The combined action regulates the menstrual cycle and reduces ectopic endometrial growth.

Side Effects

Adverse reactions may occur with Oedien and should be monitored.

Common Side Effects

  • Nausea: mild to moderate stomach upset.
  • Headache: tension‑type or migraine‑like pain.
  • Breast tenderness: transient swelling or discomfort.
  • Weight gain: modest increase in body weight.
  • Mood changes: irritability or mild depressive symptoms.
  • Spotting: breakthrough bleeding between periods.

Serious or Rare Side Effects

  • Venous thromboembolism: deep‑vein thrombosis or pulmonary embolism.
  • Hypertension: new‑onset or worsening high blood pressure.
  • Hepatic dysfunction: abnormal liver enzymes or jaundice.
  • Severe allergic reaction: rash, swelling, or anaphylaxis.
  • Visual disturbances: sudden loss of vision or eye pain.
  • Gallbladder disease: inflammation or stones.

Precautions & Warnings

Before prescribing Oedien, clinicians should evaluate patient history and risk factors.

  • Smoking status: avoid use in women >35 years who smoke.
  • Cardiovascular risk: assess for hypertension, clotting disorders, or heart disease.
  • Liver function: evaluate hepatic health before initiation.
  • Migraine history: caution in patients with migraine with aura.
  • Breast cancer history: contraindicated in active or past hormone‑sensitive malignancies.
  • Store at ambient temperature: keep below 25 °C, in original packaging, protected from moisture and light.

Avoid Interactions

Oedien may interact with several medication classes; monitoring is advised.

Major Interactions (Avoid)

  • Anticoagulants: may increase risk of thrombosis.
  • Antiepileptics (e.g., carbamazepine, phenytoin): reduce hormonal efficacy.
  • Rifampicin: decreases plasma levels of both hormones.

Moderate Interactions (Monitor Closely)

  • Antidepressants (SSRIs/SNRIs): may heighten risk of bleeding.
  • Antibiotics (macrolides, tetracyclines): slight increase in hormone concentrations.
  • Herbal supplements (St. John’s wort): may lower contraceptive effectiveness.

Frequently Asked Questions

Oedien is a combined oral tablet containing dienogest and ethinylestradiol. It is prescribed for the management of endometriosis‑related pelvic pain, dysmenorrhea (painful periods), and as a combined hormonal contraceptive to prevent pregnancy in women of reproductive age.

Dienogest is a synthetic progestogen that binds to progesterone receptors, inhibiting the growth of endometrial tissue and suppressing ovulation. When paired with ethinylestradiol, the formulation stabilises the endometrium and provides estrogenic support, together regulating the menstrual cycle and reducing ectopic endometrial lesions.

The dosage of Oedien is determined by the prescribing clinician based on the patient’s medical history and therapeutic goals. The prescriber selects the appropriate regimen and provides detailed instructions for daily oral administration.

Oedien is contraindicated during pregnancy because it is intended to prevent conception. If pregnancy occurs, the product should be discontinued immediately. Limited data are available for breastfeeding; clinicians usually advise against use while nursing unless the benefits outweigh potential risks.

To request Oedien, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, confirming trade or institutional credentials before providing pricing, availability, shipping details and any necessary import documentation.

Oedien combines dienogest, a progestogen with strong anti‑endometriotic activity, with ethinylestradiol. Compared with many other combined oral contraceptives that use levonorgestrel or desogestrel, Oedien may offer superior relief of endometriosis‑related pain while providing reliable contraception, though individual response varies.

Oedien tablets should be stored at ambient temperature, below 25 °C, in the original blister pack. Protect the product from excess moisture, heat and direct sunlight to maintain potency throughout its shelf life.

Oedien is taken orally, once daily, at the same time each day. The tablet is swallowed with water and should be taken with or without food, following the prescriber’s instructions regarding the start of the cycle.

Serious risks include venous thromboembolism (blood clots), hypertension, severe liver dysfunction and rare allergic reactions such as anaphylaxis. Patients should seek immediate medical attention if they experience symptoms like sudden leg swelling, chest pain, severe abdominal pain, jaundice or difficulty breathing.

Oedien is contraindicated in women who are pregnant, have a known or suspected hormone‑sensitive cancer, have uncontrolled hypertension, a history of thromboembolic disorders, liver disease, or who smoke and are over 35 years of age. A thorough medical evaluation is required before initiating therapy.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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