Product image of Oekolp Ovula (Estriol) supplied by GNH India

Oekolp Ovula

Active Ingredient:
Estriol
Origin:
EU

Oekolp Ovula (Estriol)

Estriol, the active ingredient in Oekolp Ovula, is an estrogen presented as a pharmaceutical preparation for oral use. It is employed to manage estrogen‑deficiency related conditions in postmenopausal women.
GNH India supplies Oekolp Ovula as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Besins Healthcare Germany Gmbh

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Indications & Clinical Uses

Estriol acts as a natural estrogen to address conditions linked to reduced endogenous hormone levels.

  • Menopausal vasomotor symptoms: reduces frequency and intensity of hot flashes and night sweats.
  • Postmenopausal osteoporosis prevention: supports bone mineral density maintenance.
  • Vaginal atrophy: improves dryness, irritation and dyspareunia associated with estrogen deficiency.

How It Works

  • Estriol binds to estrogen receptors (ERα and ERβ) in target tissues, initiating transcription of estrogen‑responsive genes. This receptor activation modulates calcium metabolism in bone, promotes mucosal integrity in the genital tract, and influences thermoregulatory centers in the hypothalamus, thereby alleviating vasomotor symptoms and supporting skeletal health.

Side Effects

Estriol may cause a range of adverse reactions, from mild to serious.

Common Side Effects

  • Nausea
  • Headache
  • Breast tenderness
  • Fluid retention
  • Mild abdominal discomfort

Serious or Rare Side Effects

  • Deep vein thrombosis
  • Pulmonary embolism
  • Stroke
  • Endometrial hyperplasia
  • Hepatic dysfunction

Precautions & Warnings

Use estriol with careful clinical assessment and monitoring.

  • Assess cardiovascular risk: evaluate history of thromboembolic disease before initiating therapy.
  • Screen for hormone‑sensitive cancers: avoid in active breast or endometrial cancer.
  • Monitor liver function: adjust use if significant hepatic impairment is present.
  • Consider age and smoking status: higher thrombotic risk in women over 35 who smoke.
  • Store at ambient temperature: keep in the original container, protect from moisture and light.

Avoid Interactions

Estriol can interact with several drug classes, requiring vigilance.

Major Interactions (Avoid)

  • Oral anticoagulants: may increase risk of thrombosis.
  • Selective estrogen receptor modulators (e.g., tamoxifen): antagonistic hormonal effects.
  • Aromatase inhibitors: reduce estriol efficacy.

Moderate Interactions (Monitor Closely)

  • CYP450 inducers (e.g., rifampin): may lower estriol plasma levels.
  • Antihypertensives: fluid retention could affect blood pressure control.
  • Lithium: estriol may raise serum lithium concentrations.

Frequently Asked Questions

Oekolp Ovula, containing estriol, is prescribed to alleviate menopausal vasomotor symptoms, to help prevent postmenopausal osteoporosis, and to treat vaginal atrophy caused by estrogen deficiency.

Estriol binds to estrogen receptors in various tissues, activating gene transcription that supports bone density, maintains vaginal mucosal health, and stabilizes hypothalamic temperature regulation, thereby reducing hot flashes.

The specific dose of Oekolp Ovula is determined by the prescribing clinician based on the patient’s condition, age, and overall health. Dosage instructions are provided on the prescription label.

Estriol is a hormone therapy and is generally not recommended for use during pregnancy or while breastfeeding unless clearly indicated by a healthcare professional, due to potential effects on the fetus or infant.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and necessary import documentation.

Oekolp Ovula delivers estriol, a weaker estrogen compared with estradiol‑based products. This may result in a lower risk of certain estrogen‑related adverse events, while still providing effective relief of menopausal symptoms and bone protection.

Store Oekolp Ovula at ambient temperature, below 25 °C, in its original packaging. Keep the product away from moisture, direct sunlight and excessive heat to maintain potency.

Oekolp Ovula is taken orally as directed by the prescribing physician. The tablet (or other oral form) should be swallowed whole with water, preferably at the same time each day.

Serious risks include thromboembolic events such as deep‑vein thrombosis, pulmonary embolism, stroke, and rare cases of endometrial hyperplasia. Patients should be monitored for signs of clotting or abnormal uterine bleeding.

Women with a history of hormone‑sensitive cancers (breast, endometrial), active thromboembolic disease, uncontrolled hypertension, or severe liver disease should avoid using Oekolp Ovula unless a specialist advises otherwise.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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