Product image of Oestrogel (Estradiol) supplied by GNH India

Oestrogel

Active Ingredient:
Estradiol
Origin:
EU

Oestrogel (Estradiol)

Estradiol, the active ingredient in Oestrogel, is a estrogen presented as a transdermal gel for skin application. It treats estrogen deficiency and relieves menopausal symptoms in women.
GNH India supplies Oestrogel as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Besins Healthcare France

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Indications & Clinical Uses

Oestrogel, an estrogen therapy, is used to address conditions related to low endogenous estrogen.

  • Menopausal symptom relief: reduces hot flashes, night sweats, and vaginal dryness.
  • Estrogen deficiency: restores physiologic estrogen levels in hypo‑estrogenic states.
  • Bone health support: contributes to maintenance of bone mineral density in post‑menopausal women.

How It Works

  • Estradiol in Oestrogel binds to intracellular estrogen receptors (ERα and ERβ), forming a hormone‑receptor complex that interacts with estrogen response elements on DNA. This modulates transcription of target genes, leading to restoration of estrogen‑dependent cellular functions in reproductive tissues, bone, cardiovascular system, and the central nervous system.

Side Effects

Common Side Effects

  • Skin irritation at the application site: redness, itching, or rash.
  • Nausea: mild to moderate upset stomach.
  • Headache: transient tension‑type headaches.
  • Breast tenderness: mild swelling or discomfort.
  • Mood changes: irritability or mild depressive symptoms.
  • Fluid retention: mild peripheral edema.

Serious or Rare Side Effects

  • Deep vein thrombosis: swelling, pain, or redness in a limb.
  • Pulmonary embolism: sudden shortness of breath, chest pain.
  • Stroke: sudden neurological deficits.
  • Myocardial infarction: chest discomfort, radiating pain.
  • Endometrial hyperplasia: abnormal uterine bleeding.
  • Liver dysfunction: jaundice, elevated liver enzymes.

Precautions & Warnings

Before initiating Oestrogel, consider the following precautions.

  • Cardiovascular risk assessment: evaluate history of thromboembolic events.
  • Cancer screening: ensure no active breast or endometrial cancer.
  • Pregnancy avoidance: contraindicated in pregnancy; use effective contraception.
  • Breastfeeding: avoid use while nursing due to potential infant exposure.
  • Lowest effective dose: prescribe the minimal dose needed for symptom control.
  • Store at room temperature: keep in the original container, protect from light and moisture.

Avoid Interactions

Oestrogel may interact with several medicines; monitoring is advised.

Major Interactions (Avoid)

  • Combined oral contraceptives: increased estrogen load may raise thrombotic risk.
  • Anticoagulants (e.g., warfarin): altered clotting parameters.
  • Strong CYP3A4 inhibitors (e.g., ketoconazole): may raise estradiol plasma levels.

Moderate Interactions (Monitor Closely)

  • Antihypertensives: possible reduction in blood pressure control.
  • Thyroid hormone replacement: may require dose adjustment.
  • Selective serotonin reuptake inhibitors: can affect hot‑flash management.

Frequently Asked Questions

Oestrogel is a transdermal estradiol gel prescribed to replace deficient estrogen levels, primarily to relieve menopausal symptoms such as hot flashes, night sweats, and vaginal dryness, and to treat estrogen deficiency in women.

Estradiol in Oestrogel penetrates the skin and binds to estrogen receptors inside target cells. This receptor activation modulates gene transcription, restoring estrogen‑dependent physiological processes in tissues like the uterus, bone, and brain.

The appropriate dose of Oestrogel is determined by the prescribing clinician based on the individual’s clinical condition, severity of symptoms, and response to therapy. Patients should follow the prescriber’s instructions and not adjust the dose on their own.

Oestrogel is generally contraindicated in pregnancy because additional estrogen can affect fetal development. Use while breastfeeding is also discouraged, as estradiol may be transferred to the infant through milk. Discuss alternatives with a healthcare professional.

To request Oestrogel, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details, and necessary import documentation.

Oestrogel delivers estradiol through the skin, bypassing first‑pass hepatic metabolism, which can result in more stable serum levels and potentially lower risk of liver‑related side effects compared with oral tablets. However, individual response varies, and the choice depends on patient preference and clinical considerations.

Store Oestrogel at room temperature, preferably below 25 °C. Keep the gel in its original container, protect it from direct light, and avoid exposure to moisture to maintain product stability.

Oestrogel is applied once daily to clean, dry, intact skin on the upper arms, shoulders, or abdomen. The prescribed amount is measured using the supplied applicator, and the area should be allowed to dry before dressing.

Serious risks include thromboembolic events such as deep‑vein thrombosis, pulmonary embolism, stroke, and myocardial infarction, as well as possible endometrial hyperplasia and liver dysfunction. Patients should be monitored closely for signs of these conditions.

Oestrogel should not be used by individuals with a history of estrogen‑dependent cancers (e.g., breast or endometrial cancer), active thromboembolic disease, uncontrolled hypertension, liver disease, or by pregnant or breastfeeding women unless specifically advised by a physician.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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