Oflaton (Ofloxacin)

Ofloxacin is a broad‑spectrum antibacterial that acts on Gram‑negative and Gram‑positive organisms in several organ systems.

• Urinary tract infection: helps eradicate the causative bacteria and relieve symptoms.
• Respiratory tract infection: aids in clearing bacterial pneumonia, bronchitis and sinusitis.
• Skin and soft‑tissue infection: assists in eliminating pathogens causing cellulitis and wound infections.
• Sexually transmitted infection: used as part of therapy for uncomplicated gonorrhoea.
• Eye infection: formulated for ophthalmic use to treat bacterial conjunctivitis.

• Ofloxacin inhibits bacterial DNA gyrase and topoisomerase IV, enzymes essential for DNA replication, transcription and repair. By binding to these enzymes, it prevents the unwinding of bacterial DNA, leading to inhibition of bacterial cell division and ultimately bacterial cell death.

Ofloxacin may cause a range of adverse reactions, from mild to severe.

Common Side Effects

• Nausea: mild stomach upset often reported.
• Diarrhea: loose stools that may be self‑limiting.
• Headache: transient headache without neurological signs.
• Dizziness: occasional light‑headedness.
• Rash: mild skin erythema or itching.
• Photosensitivity: increased skin sensitivity to sunlight.

Serious or Rare Side Effects

• Tendon rupture: sudden tendon pain or rupture, especially in the Achilles.
• QT prolongation: irregular heart rhythm detectable on ECG.
• Severe allergic reaction: anaphylaxis with swelling, breathing difficulty.
• Peripheral neuropathy: numbness or tingling in extremities.
• Clostridioides difficile infection: severe colitis with watery diarrhea.

When prescribing Ofloxacin, clinicians should evaluate patient history and monitor for specific risks.

• Renal impairment: adjust dose or avoid if severe kidney dysfunction.
• Hepatic disease: use with caution in patients with liver impairment.
• Pregnancy and lactation: avoid unless clearly needed, as fetal risk is not established.
• Concomitant QT‑prolonging drugs: monitor cardiac rhythm.
• History of tendon disorders: avoid in patients with prior tendon injury.
• Store at below 25°C: keep in original container, protect from moisture and direct sunlight.

Ofloxacin can interact with several medicines, altering its efficacy or safety profile.

Major Interactions (Avoid)

• Antacids containing aluminium or magnesium: reduce Ofloxacin absorption.
• Warfarin: may increase anticoagulant effect and bleeding risk.
• NSAIDs (non‑steroidal anti‑inflammatory drugs): heightened risk of CNS stimulation.

Moderate Interactions (Monitor Closely)

• CYP1A2 inhibitors (e.g., ciprofloxacin): may increase Ofloxacin plasma levels.
• Diabetic agents (sulfonylureas): potential for hypoglycaemia.
• Corticosteroids: increased risk of tendon rupture.