Ofloxa-Vision Kombi-Packung (Ofloxacin)

Ofloxacin is a broad‑spectrum antibacterial that acts on Gram‑negative and Gram‑positive organisms in several clinical contexts.

• Urinary tract infection: helps eradicate the causative bacteria and relieve symptoms.
• Respiratory tract infection: reduces bacterial load in conditions such as acute exacerbations of chronic bronchitis.
• Skin and soft‑tissue infection: assists in clearing infection and promoting wound healing.
• Eye infection (ophthalmic formulation): treats bacterial conjunctivitis and keratitis.
• Prostatitis: aids in eliminating the infecting organisms within the prostate gland.

• Ofloxacin inhibits bacterial DNA gyrase and topoisomerase IV, enzymes essential for DNA replication, transcription and repair. By blocking these enzymes, the drug prevents bacterial cells from proliferating and leads to cell death, providing a bactericidal effect against susceptible organisms.

Adverse reactions to Ofloxacin may vary in frequency and severity.

Common Side Effects

• Nausea
• Diarrhea
• Headache
• Dizziness
• Abdominal pain

Serious or Rare Side Effects

• Tendon rupture or inflammation
• Peripheral neuropathy
• Severe skin reactions such as Stevens‑Johnson syndrome
• QT‑interval prolongation
• Hepatotoxicity

Ofloxacin should be used with caution in specific patient groups and clinical situations.

• Renal impairment: dose adjustment may be required.
• Hepatic impairment: monitor liver function during therapy.
• History of tendon disorders: avoid use due to risk of tendon rupture.
• Concomitant use with drugs that prolong QT interval: monitor cardiac rhythm.
• Pregnancy and lactation: only use if clearly needed.
• Store at below 25°C: keep in the original packaging, protect from moisture and light.

Ofloxacin may interact with several medications, altering efficacy or safety.

Major Interactions (Avoid)

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