Product image of Ofloxa-Vision Sine (Ofloxacin) supplied by GNH India

Ofloxa-Vision Sine

Active Ingredient:
Ofloxacin
Origin:
EU

Ofloxa-Vision Sine (Ofloxacin)

Ofloxacin, the active ingredient in Ofloxa-Vision Sine, is a fluoroquinolone presented as an oral tablet for systemic use. It treats a range of bacterial infections in adult patients when prescribed by a qualified healthcare professional, targeting susceptible Gram‑negative and Gram‑positive organisms under medical supervision.

GNH India supplies Ofloxa-Vision Sine as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide. The product conforms to EU quality standards and is manufactured under GMP conditions. Our global distribution network ensures timely delivery and regulatory compliance across multiple regions.

Manufacturer / TM Owner

Omnivision Gmbh

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Indications & Clinical Uses

Ofloxacin is a fluoroquinolone antibiotic used to treat bacterial infections in various organ systems.

  • Urinary tract infection: eradicates susceptible uropathogens and resolves symptoms such as dysuria and frequency.
  • Respiratory tract infection: treats acute exacerbations of bronchitis and community‑acquired pneumonia caused by susceptible bacteria.
  • Skin and soft‑tissue infection: clears infections like cellulitis and wound infections due to Gram‑negative organisms.
  • Sexually transmitted infection (gonorrhea): eliminates Neisseria gonorrhoeae strains sensitive to ofloxacin.

How It Works

  • Ofloxacin exerts its antibacterial effect by inhibiting bacterial DNA gyrase (topoisomerase II) and topoisomerase IV, enzymes essential for DNA replication, transcription and repair. By binding to the enzyme‑DNA complex, it prevents the resealing of DNA strands after cleavage, leading to accumulation of double‑strand breaks and bacterial cell death. This bactericidal action is effective against a broad spectrum of Gram‑negative and some Gram‑positive organisms.

Side Effects

Ofloxacin may cause a range of adverse reactions, varying from mild to severe.

Common Side Effects

  • Nausea
  • Diarrhea
  • Headache
  • Dizziness
  • Photosensitivity
  • Abdominal pain

Serious or Rare Side Effects

  • Tendon rupture or tendinitis
  • QT interval prolongation
  • Severe allergic reactions (anaphylaxis, Stevens‑Johnson syndrome)
  • Clostridioides difficile‑associated diarrhea
  • Peripheral neuropathy
  • Hepatotoxicity

Precautions & Warnings

When prescribing Ofloxa‑Vision Sine, clinicians should observe several safety precautions to minimize risks.

  • Indication restriction: use only for infections confirmed or strongly suspected to be caused by susceptible bacteria.
  • Pregnancy and lactation: avoid use during pregnancy and breastfeeding unless benefits outweigh risks.
  • Age limitation: not recommended for children under 18 years for most indications.
  • Renal impairment: adjust dose or monitor renal function in patients with reduced kidney function.
  • Concomitant medications: avoid simultaneous use with systemic corticosteroids or NSAIDs due to increased tendon injury risk.
  • Store at ambient temperature: keep below 25 °C, in original packaging, protected from moisture and light.

Avoid Interactions

Ofloxacin can interact with other medicines, altering its efficacy or safety profile.

Major Interactions (Avoid)

  • Antacids containing magnesium or aluminum: reduce absorption.
  • Warfarin: may enhance anticoagulant effect and increase INR.
  • Theophylline: plasma levels can rise, risking toxicity.
  • Cyclosporine: increased exposure may lead to nephrotoxicity.
  • Diabetic agents: risk of hypoglycemia may be heightened.

Moderate Interactions (Monitor Closely)

  • NSAIDs: combined use raises tendon injury risk.
  • Corticosteroids: additive risk of tendon rupture.
  • Antidepressants (e.g., SSRIs): potential QT prolongation.
  • Antiretrovirals (e.g., zidovudine): may affect drug levels.
  • Vitamin K antagonists: monitor INR closely.

Frequently Asked Questions

Ofloxa-Vision Sine contains ofloxacin, an oral fluoroquinolone antibiotic indicated for treating susceptible bacterial infections such as urinary tract infections, respiratory tract infections, skin and soft‑tissue infections, and certain sexually transmitted infections like gonorrhea.

Ofloxacin inhibits bacterial DNA gyrase and topoisomerase IV, enzymes required for DNA replication and transcription. By blocking these enzymes, it prevents bacterial DNA from resealing after cleavage, leading to lethal DNA damage and bacterial cell death.

The dosage of Ofloxa-Vision Sine is determined by the prescribing clinician based on the infection type, severity, patient age, weight, renal function and local resistance patterns. Patients should follow the prescriber’s instructions and not alter the dose on their own.

Ofloxacin is generally contraindicated during pregnancy and lactation because animal studies have shown potential risks to the fetus and newborn. It should only be used if the potential benefit justifies the risk and no safer alternative is available.

Enquiries can be submitted on the product page at gnhindia.com by specifying the required quantity. GNH India supplies hospitals, pharmacies and procurement teams across international markets, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Ofloxacin shares the class‑wide mechanism of DNA gyrase inhibition with other fluoroquinolones such as ciprofloxacin and levofloxacin. Compared with ciprofloxacin, ofloxacin often has a broader spectrum against certain Gram‑positive organisms but a similar safety profile, including the same cautions for tendon injury and QT prolongation.

Store Ofloxa-Vision Sine at ambient temperature, preferably below 25 °C. Keep the tablets in the original blister pack, protect them from moisture and direct sunlight, and ensure the container is tightly closed to maintain product stability.

Ofloxa-Vision Sine is supplied as oral tablets. The tablets should be swallowed whole with a full glass of water. They may be taken with or without food, but patients should follow any specific instructions from their healthcare provider.

Serious adverse events include tendon rupture or tendinitis, especially in older adults or those on corticosteroids; QT interval prolongation leading to cardiac arrhythmias; severe hypersensitivity reactions such as anaphylaxis or Stevens‑Johnson syndrome; and Clostridioides difficile‑associated colitis.

Patients with a known hypersensitivity to ofloxacin or other fluoroquinolones should avoid the product. It is also contraindicated in children and adolescents for most indications, pregnant or breastfeeding women, and individuals taking medications that significantly increase the risk of tendon injury or QT prolongation.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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