Product image of Ofloxacină Laropharm (Ofloxacin) supplied by GNH India

Ofloxacină Laropharm

Active Ingredient:
Ofloxacin
Origin:
EU

Ofloxacină Laropharm (Ofloxacin)

Ofloxacin, the active ingredient in Ofloxacină Laropharm, is a fluoroquinolone antibiotic presented as a tablet for oral use. It treats a variety of bacterial infections in adults and children when prescribed by a healthcare professional.

GNH India supplies Ofloxacină Laropharm as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

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Indications & Clinical Uses

Ofloxacin is a broad‑spectrum antibacterial agent used to treat infections of several organ systems.

  • Urinary tract infection: helps eradicate the causative bacteria and relieve symptoms.
  • Respiratory tract infection: aids in clearing bacterial pneumonia, bronchitis and sinusitis.
  • Skin and soft‑tissue infection: reduces bacterial load in cellulitis, abscesses and wound infections.
  • Eye infection (conjunctivitis): provides topical bacterial control when formulated for ocular use.
  • Sexually transmitted infection: treats uncomplicated gonorrhoea caused by susceptible strains.

How It Works

  • Ofloxacin inhibits bacterial DNA gyrase and topoisomerase IV, enzymes essential for DNA replication, transcription and repair. By binding to these enzymes, the drug prevents the supercoiling and separation of bacterial DNA, leading to inhibition of bacterial cell division and ultimately bacterial cell death.

Side Effects

Adverse reactions to ofloxacin may range from mild to severe and should be monitored during therapy.

Common Side Effects

  • Nausea: mild stomach upset that may improve with food.
  • Diarrhea: loose stools, occasionally watery.
  • Headache: transient cranial discomfort.
  • Dizziness: sensation of light‑headedness or unsteadiness.
  • Rash: mild skin erythema or itching.
  • Photosensitivity: increased skin reaction to sunlight.

Serious or Rare Side Effects

  • Tendon rupture: sudden pain or loss of function, especially in the Achilles tendon.
  • QT interval prolongation: irregular heart rhythm detectable on ECG.
  • Severe allergic reaction: swelling, hives, or difficulty breathing.
  • Peripheral neuropathy: tingling, numbness or weakness in extremities.
  • Hepatotoxicity: abnormal liver enzymes or jaundice.
  • Clostridioides difficile infection: severe diarrhea following antibiotic use.

Precautions & Warnings

Before initiating therapy with ofloxacin, consider the following safety measures:

  • Renal impairment: adjust dose in patients with reduced kidney function.
  • Hepatic impairment: use cautiously in liver disease.
  • History of tendon disorders: avoid in patients with prior tendon injury.
  • Cardiac risk: monitor ECG in patients with known QT prolongation.
  • Pregnancy and lactation: contraindicated unless benefits outweigh risks.
  • Store at below 25°C: keep in the original container, protect from moisture and direct sunlight.

Avoid Interactions

Ofloxacin can interact with several medicines, altering efficacy or safety.

Major Interactions (Avoid)

  • Antacids containing aluminum or magnesium: reduce absorption of ofloxacin.
  • Warfarin: may increase anticoagulant effect and bleeding risk.
  • Cyclosporine: increased risk of tendon toxicity.

Moderate Interactions (Monitor Closely)

  • Non‑steroidal anti‑inflammatory drugs (NSAIDs): may heighten CNS stimulation.
  • Theophylline: plasma levels may rise, leading to toxicity.
  • Oral hypoglycemics: ofloxacin can enhance glucose‑lowering effect.

Frequently Asked Questions

Ofloxacină Laropharm contains the fluoroquinolone ofloxacin, which is prescribed to treat a range of bacterial infections such as urinary‑tract infections, respiratory‑tract infections, skin and soft‑tissue infections, and certain eye infections when the formulation is appropriate.

Ofloxacin inhibits bacterial DNA gyrase and topoisomerase IV, enzymes that are essential for DNA replication and transcription. This inhibition prevents bacterial cells from multiplying, leading to bacterial death and resolution of the infection.

The dosage of Ofloxacină Laropharm is determined by the prescribing clinician based on the type and severity of the infection, patient age, weight, and renal function. Patients should follow the prescriber’s instructions and the product label.

Ofloxacin is generally contraindicated in pregnancy and lactation unless the potential benefit justifies the risk. It can cross the placenta and appear in breast milk, so clinicians weigh the infection severity against possible fetal or infant exposure.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any required import documentation.

Ofloxacin is a second‑generation fluoroquinolone offering broad‑spectrum activity against Gram‑negative and some Gram‑positive bacteria. Compared with older agents like ciprofloxacin, it has similar efficacy but may have a slightly different safety profile, particularly regarding tendon‑related risks.

Store the tablets at temperatures below 25 °C, in the original packaging, protected from moisture and direct sunlight. Do not store in humid or excessively hot environments to maintain product stability.

Ofloxacină Laropharm is supplied as oral tablets that are taken with a full glass of water. The tablets may be taken with or without food, but patients should avoid concurrent intake of antacids containing aluminum or magnesium, which can reduce absorption.

Serious risks include tendon rupture, especially of the Achilles tendon, QT‑interval prolongation leading to cardiac arrhythmias, severe allergic reactions, peripheral neuropathy, and Clostridioides difficile‑associated colitis. Patients should seek immediate medical attention if they notice sudden tendon pain, palpitations, severe rash, or persistent diarrhea.

Ofloxacin should not be used by individuals with a known hypersensitivity to fluoroquinolones, those with a history of tendon disorders related to fluoroquinolone use, patients with significant cardiac arrhythmias or prolonged QT interval, and pregnant or breastfeeding women unless absolutely necessary.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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