Ofloxacin Bristol Laboratories (Ofloxacin)

Ofloxacin is a broad‑spectrum antibacterial that acts on Gram‑negative and Gram‑positive organisms in several infection pathways.

• Urinary tract infection: helps eradicate the causative bacteria and relieve symptoms.
• Respiratory tract infection: reduces bacterial load in conditions such as acute exacerbations of chronic bronchitis.
• Skin and soft‑tissue infection: assists in clearing infection and promoting wound healing.

• Ofloxacin inhibits bacterial DNA gyrase and topoisomerase IV, enzymes essential for DNA replication, transcription and repair. By blocking these enzymes, the drug prevents bacterial cell division and leads to bacterial cell death, providing a bactericidal effect against susceptible organisms.

Adverse reactions to Ofloxacin may vary in frequency and severity.

Common Side Effects

• Nausea
• Diarrhea
• Headache
• Dizziness
• Abdominal pain

Serious or Rare Side Effects

• Tendon rupture or inflammation
• Peripheral neuropathy
• Severe skin reactions such as Stevens‑Johnson syndrome
• QT interval prolongation
• Clostridioides difficile‑associated colitis

When using Ofloxacin, consider the following safety measures:

• Renal impairment: adjust dose based on renal function.
• Hepatic impairment: use with caution in patients with liver disease.
• History of tendon disorders: avoid if previous tendon injury related to fluoroquinolones.
• Concomitant QT‑prolonging drugs: monitor cardiac rhythm.
• Pregnancy and lactation: only use if clearly needed.

Store at below 25°C: keep in the original packaging, protect from moisture and light.

Ofloxacin can interact with several medicines, requiring careful management.

Major Interactions (Avoid)

• Antacids containing aluminium or magnesium: may reduce absorption.
• Warfarin: may increase anticoagulant effect and bleeding risk.
• Cyclosporine: increased risk of neurotoxicity.

Moderate Interactions (Monitor Closely)

• Theophylline: may increase plasma concentrations.
• Oral hypoglycaemic agents: may cause abnormal glucose levels.
• Non‑steroidal anti‑inflammatory drugs (NSAIDs): may increase risk of central nervous system effects.