Product image of Ofloxacin-Pos (Ofloxacin) supplied by GNH India

Ofloxacin-Pos

Active Ingredient:
Ofloxacin
Origin:
EU

Ofloxacin-Pos (Ofloxacin)

Ofloxacin, the active ingredient in Ofloxacin-Pos, is a fluoroquinolone antibiotic presented as a tablet for oral use. It treats a range of bacterial infections in adults and children as prescribed.

GNH India supplies Ofloxacin-Pos as a licensed, GDP-compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Ursapharm Spol. S.R.O.

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Indications & Clinical Uses

Ofloxacin is a broad‑spectrum fluoroquinolone used to manage infections caused by susceptible bacteria.

  • Urinary tract infection: clears infection by targeting common Gram‑negative uropathogens.
  • Acute bacterial sinusitis: reduces bacterial load in the sinus mucosa.
  • Skin and soft‑tissue infection: eradicates susceptible Staphylococcus and Streptococcus species.
  • Gonorrhea: effective against Neisseria gonorrhoeae strains sensitive to fluoroquinolones.
  • Chronic bacterial prostatitis: penetrates prostatic tissue to treat persistent infection.

How It Works

  • Ofloxacin inhibits bacterial DNA gyrase and topoisomerase IV, enzymes essential for DNA replication, transcription, and repair. By binding to these enzymes, it prevents the supercoiling and relaxation of DNA, leading to inhibition of bacterial cell division and ultimately bacterial cell death.

Side Effects

Common Side Effects

  • Nausea: mild to moderate stomach upset.
  • Diarrhea: loose stools, often self‑limiting.
  • Headache: transient cranial discomfort.
  • Dizziness: occasional light‑headedness.
  • Rash: mild skin irritation.
  • Photosensitivity: increased sun sensitivity.

Serious or Rare Side Effects

  • Tendon rupture: especially Achilles tendon, requiring immediate medical attention.
  • QT interval prolongation: may cause cardiac arrhythmias.
  • Severe allergic reactions: anaphylaxis, angioedema.
  • Central nervous system effects: seizures, confusion.
  • Hepatotoxicity: elevated liver enzymes or jaundice.
  • Peripheral neuropathy: numbness or tingling in extremities.

Precautions & Warnings

Before using Ofloxacin, consider the following precautions:

  • Tendon disorders: avoid use in patients with recent tendon injury or corticosteroid therapy.
  • Cardiac risk: monitor QT interval in patients with known arrhythmias.
  • Renal impairment: adjust dose in severe kidney dysfunction.
  • Hepatic dysfunction: use cautiously in liver disease.
  • Pregnancy and lactation: avoid unless clearly needed, discuss risks with a healthcare professional.
  • Storage: Store below 25°C: keep in the original pack, protect from moisture.

Avoid Interactions

Major Interactions (Avoid)

  • Antacids containing aluminum or magnesium: reduce absorption of Ofloxacin.
  • Warfarin: may increase anticoagulant effect, requiring INR monitoring.
  • Cyclosporine: increased risk of neurotoxicity.
  • Theophylline: may raise plasma levels, leading to toxicity.
  • Non‑steroidal anti‑inflammatory drugs (NSAIDs): heightened risk of CNS stimulation.

Moderate Interactions (Monitor Closely)

  • Oral contraceptives: reduced efficacy, advise backup contraception.
  • Diabetic agents: may affect blood glucose control.
  • Corticosteroids: increased risk of tendon rupture.
  • Probenecid: may increase Ofloxacin plasma concentrations.
  • Rifampin: may lower Ofloxacin levels, reducing effectiveness.

Frequently Asked Questions

Ofloxacin-Pos is indicated for bacterial infections such as urinary tract infections, acute bacterial sinusitis, skin and soft‑tissue infections, gonorrhea, and chronic bacterial prostatitis, provided the causative organisms are susceptible to fluoroquinolones.

Ofloxacin blocks bacterial DNA gyrase and topoisomerase IV, enzymes needed for DNA replication and transcription. This inhibition stops bacterial cell division, leading to bacterial death and resolution of the infection.

The dose of Ofloxacin-Pos is determined by the prescribing clinician based on the type and severity of infection, patient age, renal function, and other clinical factors. Patients should follow the prescriber’s instructions exactly.

Ofloxacin-Pos should be used in pregnancy or while breastfeeding only if clearly needed and after a risk‑benefit assessment by a healthcare professional, as fluoroquinolones may affect fetal cartilage development and are excreted in breast milk.

To order, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Ofloxacin offers broad‑spectrum activity against Gram‑negative and Gram‑positive bacteria and has good tissue penetration, making it comparable to other fluoroquinolones like ciprofloxacin. Choice depends on susceptibility patterns, infection site, patient tolerance and specific safety considerations.

Ofloxacin-Pos tablets should be stored below 25 °C, in the original packaging, protected from moisture and direct sunlight. Do not store in a bathroom or near heat sources to maintain product stability.

Ofloxacin-Pos is taken orally with a full glass of water. It may be taken with or without food, but if gastrointestinal upset occurs, it can be taken with meals. Swallow tablets whole; do not crush or chew unless instructed by a healthcare professional.

Serious risks include tendon rupture (especially Achilles), QT interval prolongation leading to cardiac arrhythmias, severe allergic reactions such as anaphylaxis, central nervous system effects like seizures, and rare cases of hepatotoxicity or peripheral neuropathy.

Patients with a known hypersensitivity to fluoroquinolones, a history of tendon disorders related to fluoroquinolone use, uncontrolled cardiac arrhythmias, or those taking medications that significantly interact (e.g., certain antacids, warfarin) should avoid Ofloxacin-Pos unless advised otherwise by a clinician.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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