Product image of Ofloxacin-Pos (Ofloxacin) supplied by GNH India

Ofloxacin-Pos

Active Ingredient:
Ofloxacin
Origin:
EU

Ofloxacin-Pos (Ofloxacin)

Ofloxacin, the active ingredient in Ofloxacin-Pos, is a fluoroquinolone antibiotic presented as a sterile ophthalmic solution for ocular use. It treats bacterial infections of the eye, such as conjunctivitis, keratitis and blepharitis, in adult and pediatric patients as directed by a healthcare professional.

GNH India supplies Ofloxacin-Pos as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide. The company adheres to EU quality standards and provides regulatory documentation for cross‑border procurement. Customers benefit from reliable batch release, traceability and on‑time delivery across multiple regions.

Manufacturer / TM Owner

Ursapharm Poland Sp. Z. O.O.

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Indications & Clinical Uses

Ofloxacin is a fluoroquinolone antibiotic used to treat bacterial infections of the ocular surface.

  • Bacterial conjunctivitis: reduces bacterial load and accelerates resolution of redness and discharge.
  • Keratitis: eradicates causative bacteria, promoting corneal healing and preventing scarring.
  • Blepharitis: eliminates bacterial colonisation of eyelid margins, improving inflammation and lid hygiene.
  • Post‑operative ocular infection: prevents bacterial proliferation after eye surgery.

How It Works

  • Ofloxacin inhibits bacterial DNA gyrase and topoisomerase IV, enzymes essential for DNA supercoiling and replication. By binding to these enzymes, it blocks bacterial DNA synthesis and transcription, leading to rapid bacterial cell death. The drug exhibits concentration‑dependent bactericidal activity against a broad spectrum of Gram‑negative and Gram‑positive ocular pathogens.

Side Effects

Ocular administration of Ofloxacin-Pos may be associated with local adverse reactions.

Common Side Effects

  • Eye irritation or burning sensation.
  • Stinging or foreign‑body feeling.
  • Transient blurred vision.
  • Conjunctival hyperemia.

Serious or Rare Side Effects

  • Corneal ulceration or perforation.
  • Severe allergic reaction including eyelid edema.
  • Stevens‑Johnson syndrome or toxic epidermal necrolysis involving the eye.
  • Vision loss due to intraocular inflammation.
  • Persistent or worsening ocular pain.

Precautions & Warnings

Before prescribing Ofloxacin-Pos, clinicians should consider the following safety measures.

  • Allergy assessment: avoid use in patients with known hypersensitivity to fluoroquinolones.
  • Contact lens wear: discontinue lenses during treatment to reduce risk of keratitis.
  • Systemic absorption: limit use to the eye; avoid excessive dosing.
  • Pregnancy and lactation: safety not established; use only if benefits outweigh risks.
  • Drug interactions: avoid concomitant use with ophthalmic corticosteroids unless directed.
  • Store at ambient temperature: keep in original container, protect from light and moisture.

Avoid Interactions

Ofloxacin-Pos may interact with other ophthalmic or systemic agents.

Major Interactions (Avoid)

  • Systemic fluoroquinolones: concurrent systemic therapy may increase risk of tendon rupture.
  • Topical corticosteroids: may reduce antibacterial efficacy and increase infection risk.
  • Non‑steroidal anti‑inflammatory eye drops: potential for reduced drug penetration.

Moderate Interactions (Monitor Closely)

  • Anticholinergic eye drops: may affect ocular surface tolerance.
  • Other ophthalmic antibiotics: assess for additive toxicity.
  • Herbal supplements containing quinine: may potentiate fluoroquinolone effects.

Frequently Asked Questions

Ofloxacin-Pos is a prescription ophthalmic solution containing the fluoroquinolone antibiotic ofloxacin. It is indicated for the treatment of bacterial eye infections such as conjunctivitis, keratitis and blepharitis, where it helps eliminate the causative bacteria and promote healing.

Ofloxacin blocks bacterial DNA gyrase and topoisomerase IV, enzymes required for DNA replication and transcription. By inhibiting these targets, the drug prevents bacterial cell division and leads to rapid bacterial death, providing a bactericidal effect against a broad range of ocular pathogens.

The dosing regimen for Ofloxacin-Pos is determined by the prescribing clinician based on the specific infection, severity and patient factors. Typical regimens involve one to two drops per eye at defined intervals, but the exact schedule should always follow the healthcare professional’s instructions.

Safety data for Ofloxacin-Pos in pregnancy and lactation are limited, and the product is classified as having an unknown pregnancy category. It should only be used when the potential benefit justifies any possible risk to the fetus or infant, and the decision must be made by a qualified prescriber.

To place an order, visit the product page on gnhindia.com, enter the required quantity and submit the enquiry form. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Ofloxacin belongs to the fluoroquinolone class, offering broad‑spectrum activity against both Gram‑negative and Gram‑positive bacteria. Compared with older agents such as chloramphenicol or erythromycin, ofloxacin often provides faster bacterial eradication and a lower risk of resistance, though choice should be guided by local susceptibility patterns and clinician preference.

Store Ofloxacin-Pos at ambient temperature, preferably below 25 °C, in its original packaging. Protect the container from direct sunlight, moisture and extreme temperatures. Keep the product out of reach of children and discard any solution that appears discoloured or cloudy.

The solution is applied topically to the affected eye(s) using a sterile dropper. The patient should wash their hands, tilt the head back, pull down the lower eyelid, and place the prescribed number of drops into the conjunctival sac. The eye should be closed gently for a few seconds to allow absorption.

Serious adverse events, although rare, include corneal ulceration, severe allergic reactions such as eyelid edema, Stevens‑Johnson syndrome, toxic epidermal necrolysis and significant vision loss. Any sudden worsening of ocular symptoms or systemic allergic signs should prompt immediate medical evaluation.

Patients with a known hypersensitivity to ofloxacin, other fluoroquinolones, or any component of the formulation should avoid the product. It is also contraindicated in individuals where a severe ocular surface disease requires alternative therapy, and caution is advised in pregnant or nursing women until benefits are clearly established.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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