Ofloxacin Stada (Ofloxacin)

Ofloxacin is a broad‑spectrum antibacterial that targets Gram‑negative and Gram‑positive organisms in several infection categories.

• Urinary tract infection: eradicates causative bacteria and resolves symptoms such as dysuria and frequency.
• Acute exacerbation of chronic bronchitis: reduces bacterial load and improves breathing difficulty.
• Skin and soft‑tissue infection: clears cellulitis or wound infections caused by susceptible organisms.
• Uncomplicated gonorrhea: eliminates Neisseria gonorrhoeae and prevents transmission.
• Bacterial conjunctivitis: treats eye infection and alleviates redness and discharge.

• Ofloxacin inhibits bacterial DNA gyrase (topoisomerase II) and topoisomerase IV, enzymes essential for DNA replication, transcription, and repair. By binding to these enzymes, it prevents the supercoiling and separation of DNA strands, leading to bacterial cell death and a bactericidal effect against susceptible microorganisms.

Common Side Effects

• Nausea: mild to moderate stomach upset.
• Diarrhea: loose stools that may be self‑limiting.
• Headache: transient cranial discomfort.
• Dizziness: occasional light‑headed sensation.
• Abdominal pain: cramp‑like discomfort.
• Rash: mild skin irritation.

Serious or Rare Side Effects

• Tendon rupture: sudden pain and loss of function, especially in the Achilles tendon.
• QT interval prolongation: risk of cardiac arrhythmias.
• Severe allergic reaction: anaphylaxis, swelling, or breathing difficulty.
• Clostridioides difficile infection: severe colitis with watery diarrhea.
• Peripheral neuropathy: tingling or numbness in extremities.
• Stevens‑Johnson syndrome: severe skin blistering and mucosal involvement.

Before initiating therapy, consider the following safety measures.

• Assess renal function: adjust dosing in patients with impaired clearance.
• Avoid in patients with known hypersensitivity to fluoroquinolones.
• Use with caution in the elderly: higher incidence of tendon injury.
• Monitor for QT prolongation when combined with other QT‑affecting agents.
• Avoid concurrent use with antacids containing aluminum or magnesium: may reduce absorption.
• Store at room temperature: keep in the original container, protect from moisture and light.

Ofloxacin may interact with several medicines; monitoring is essential.

Major Interactions (Avoid)

• Antacids or supplements containing aluminum, magnesium, calcium, or iron: decrease Ofloxacin absorption.
• Warfarin: increased anticoagulant effect, risk of bleeding.
• Cyclosporine: elevated cyclosporine levels, potential nephrotoxicity.
• Theophylline: heightened theophylline toxicity.
• Oral hypoglycemic agents: enhanced hypoglycaemic effect.

Moderate Interactions (Monitor Closely)

• NSAIDs: increased risk of central nervous system stimulation.
• Corticosteroids: additive risk of tendon rupture.
• Other QT‑prolonging drugs: monitor cardiac rhythm.
• Insulin: potential for additive hypoglycaemia.
• Oral contraceptives: reduced efficacy, consider alternative contraception.