Product image of Ofloxacin Teva Uk (Ofloxacin) supplied by GNH India

Ofloxacin Teva Uk

Active Ingredient:
Ofloxacin
Origin:
EU

Ofloxacin Teva Uk (Ofloxacin)

Ofloxacin, the active ingredient in Ofloxacin Teva Uk, is a fluoroquinolone antibiotic presented as a tablet for oral use. It treats a range of bacterial infections in adults and children when prescribed by a qualified healthcare professional.

GNH India supplies Ofloxacin Teva Uk as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Teva Uk Limited

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Indications & Clinical Uses

Ofloxacin is a broad‑spectrum fluoroquinolone used to treat bacterial infections in several organ systems.

  • Urinary Tract Infections: eradicates susceptible Gram‑negative and Gram‑positive uropathogens, relieving symptoms and preventing complications.
  • Respiratory Tract Infections: targets pathogens causing acute exacerbations of chronic bronchitis and community‑acquired pneumonia.
  • Skin and Soft Tissue Infections: eliminates causative bacteria in cellulitis, abscesses and wound infections.
  • Gonorrhea: provides effective therapy against Neisseria gonorrhoeae strains susceptible to fluoroquinolones.

How It Works

  • Ofloxacin inhibits bacterial DNA gyrase and topoisomerase IV, enzymes essential for DNA replication, transcription, and repair. By stabilizing the enzyme‑DNA complex, it prevents the resealing of DNA breaks, leading to bacterial cell death. This bactericidal action is concentration‑dependent and effective against a wide range of Gram‑negative and some Gram‑positive organisms.

Side Effects

Adverse reactions to ofloxacin can vary in frequency and severity.

Common Side Effects

  • Nausea: mild to moderate stomach upset.
  • Diarrhea: loose stools, occasionally watery.
  • Headache: transient cranial discomfort.
  • Dizziness: sensation of light‑headedness.
  • Abdominal pain: cramping or discomfort.
  • Rash: mild skin erythema.

Serious or Rare Side Effects

  • Tendon rupture: sudden tendon pain or rupture, especially Achilles.
  • QT interval prolongation: risk of cardiac arrhythmias.
  • Severe allergic reactions: anaphylaxis, angioedema.
  • Clostridioides difficile infection: severe colitis.
  • Peripheral neuropathy: numbness or tingling.
  • Hepatic dysfunction: elevated liver enzymes or jaundice.

Precautions & Warnings

Before initiating therapy, clinicians should consider several safety aspects.

  • Renal function assessment: adjust dose in impaired clearance.
  • Tendon disorder avoidance: do not use in patients with known tendon disease.
  • Pregnancy caution: avoid unless benefits outweigh risks.
  • QT monitoring: ECG recommended for patients with cardiac risk factors.
  • Concomitant medication review: evaluate for interactions that may increase toxicity.
  • Store at ambient temperature: keep in original packaging, protect from moisture and direct sunlight.

Avoid Interactions

Ofloxacin may interact with other medicines, altering efficacy or safety.

Major Interactions (Avoid)

  • Antacids containing aluminum or magnesium: reduce ofloxacin absorption.
  • NSAIDs: increase risk of central nervous system adverse effects.
  • Warfarin: potentiate anticoagulant effect, raising bleeding risk.
  • Theophylline: elevate plasma levels, risking toxicity.
  • Cyclosporine: increase cyclosporine concentrations, enhancing nephrotoxicity.

Moderate Interactions (Monitor Closely)

  • Oral contraceptives: may reduce hormonal efficacy, consider backup method.
  • Diabetic agents: heightened risk of hypoglycemia.
  • Corticosteroids: combined use raises tendon rupture risk.
  • SSRIs: additive effect on QT prolongation.
  • Rifampin: induces metabolism, lowering ofloxacin exposure.

Frequently Asked Questions

Ofloxacin Teva Uk is indicated for a variety of bacterial infections, including uncomplicated urinary tract infections, acute exacerbations of chronic bronchitis, community‑acquired pneumonia, skin and soft‑tissue infections, and uncomplicated gonorrhea, when the causative organisms are susceptible to fluoroquinolones.

Ofloxacin blocks bacterial DNA gyrase and topoisomerase IV, enzymes that unwind and reseal DNA during replication. This inhibition creates lethal DNA breaks, halting bacterial growth and leading to cell death, which provides a bactericidal effect against a broad spectrum of Gram‑negative and some Gram‑positive organisms.

The dosage of Ofloxacin Teva Uk is determined by the prescribing clinician based on the type and severity of infection, patient age, weight, renal function, and local resistance patterns. Healthcare professionals set the appropriate regimen and duration for each individual case.

Ofloxacin is generally avoided in pregnancy and lactation unless the potential benefit justifies the risk, as animal studies have shown adverse fetal effects. Women who are pregnant, planning pregnancy, or breastfeeding should discuss alternatives with their healthcare provider.

To request Ofloxacin Teva Uk, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Ofloxacin shares the class‑wide mechanism of DNA gyrase inhibition but differs in its spectrum and pharmacokinetics. Compared with ciprofloxacin, ofloxacin has similar activity against Gram‑negative pathogens but may offer better penetration in certain tissues, while levofloxacin often provides once‑daily dosing. Choice depends on infection site, susceptibility data and patient factors.

Ofloxacin Teva Uk tablets should be stored at ambient temperature, below 25 °C, in the original container to protect from moisture and light. Keep the product out of reach of children and avoid storing in bathrooms or other humid environments.

Ofloxacin Teva Uk is supplied as oral tablets that are taken with a full glass of water. The tablets may be taken with or without food, but antacids containing aluminum or magnesium should be spaced at least two hours apart to avoid reduced absorption.

Serious risks include tendon rupture (especially Achilles), QT interval prolongation leading to arrhythmias, severe allergic reactions such as anaphylaxis, Clostridioides difficile‑associated colitis, peripheral neuropathy, and hepatic injury. Patients should be advised to seek immediate medical attention if they experience sudden tendon pain, palpitations, severe rash, or persistent diarrhea.

Ofloxacin Teva Uk is contraindicated in patients with a known hypersensitivity to fluoroquinolones, a history of tendon disorders related to fluoroquinolone use, and those with established QT prolongation or ventricular arrhythmias. Caution is also advised for individuals with severe renal impairment or those taking medications that significantly interact with ofloxacin.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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