Product image of Ofloxacin Ud Stulln (Ofloxacin) supplied by GNH India

Ofloxacin Ud Stulln

Active Ingredient:
Ofloxacin
Origin:
EU

Ofloxacin Ud Stulln (Ofloxacin)

Ofloxacin, the active ingredient in Ofloxacin Ud Stulln, is a fluoroquinolone antibiotic presented as an oral tablet for systemic use. It treats a range of bacterial infections in adults and children when prescribed by a qualified healthcare professional.

GNH India supplies Ofloxacin Ud Stulln as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide. The company adheres to stringent quality standards and provides regulatory documentation for export to multiple regions. Customers benefit from reliable logistics and responsive technical support throughout the procurement process.

Manufacturer / TM Owner

Pharma Stulln Gmbh

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Indications & Clinical Uses

Ofloxacin is a fluoroquinolone antibiotic indicated for several bacterial infections affecting different organ systems.

  • Uncomplicated urinary tract infection: eradicates susceptible uropathogens and resolves symptoms such as dysuria and frequency.
  • Acute bacterial sinusitis: reduces bacterial load and improves sinus drainage, relieving facial pain and congestion.
  • Community‑acquired lower respiratory tract infection: targets common respiratory pathogens to improve cough, sputum production and fever.
  • Skin and soft‑tissue infections: eliminates causative bacteria, aiding healing of cellulitis, abscesses and wound infections.
  • Gonococcal urethritis: effectively treats Neisseria gonorrhoeae infections, preventing complications and transmission.

How It Works

  • Ofloxacin exerts its antibacterial activity by inhibiting bacterial DNA gyrase (topoisomerase II) and topoisomerase IV, enzymes essential for DNA replication, transcription and repair. By stabilizing the enzyme‑DNA complex, it prevents the resealing of DNA strands, leading to accumulation of double‑strand breaks and bacterial cell death. The dual targeting of gyrase and topoisomerase IV broadens its spectrum against Gram‑negative and Gram‑positive organisms.

Side Effects

Ofloxacin may cause a range of adverse reactions, varying from mild to severe.

Common Side Effects

  • Nausea: mild stomach upset often transient.
  • Diarrhea: loose stools that may be self‑limiting.
  • Headache: mild to moderate intensity.

Serious or Rare Side Effects

  • Tendon rupture: sudden pain and loss of function, especially in the Achilles tendon.
  • QT interval prolongation: cardiac rhythm disturbances that may lead to arrhythmia.
  • Severe allergic reaction: rash, swelling, bronchospasm or anaphylaxis.

Precautions & Warnings

When using Ofloxacin, several precautions should be observed to minimize risk.

  • Renal impairment: adjust therapy and monitor renal function closely.
  • History of tendon disorders: avoid use or discontinue promptly if tendon pain occurs.
  • Concomitant QT‑prolonging drugs: assess risk of cardiac arrhythmias.
  • Pregnancy and lactation: use only if benefits outweigh potential risks.
  • Elderly patients: increased susceptibility to CNS effects; monitor closely.
  • Store below 25°C: keep in original container, protect from moisture and light.

Avoid Interactions

Ofloxacin can interact with other medicines, requiring attention to avoid reduced efficacy or increased toxicity.

Major Interactions (Avoid)

  • Antacids containing magnesium or aluminum: reduce absorption; separate dosing by at least 2 hours.
  • Non‑steroidal anti‑inflammatory drugs (NSAIDs): increase risk of CNS toxicity.
  • Cyclosporine: may raise ofloxacin plasma levels, enhancing toxicity.

Moderate Interactions (Monitor Closely)

  • Warfarin: may potentiate anticoagulant effect; monitor INR.
  • Theophylline: possible increase in serum theophylline concentrations.
  • Corticosteroids: heightened risk of tendon rupture; advise caution.

Frequently Asked Questions

Ofloxacin Ud Stulln is a fluoroquinolone antibiotic indicated for the treatment of uncomplicated urinary tract infections, acute bacterial sinusitis, community‑acquired lower respiratory tract infections, skin and soft‑tissue infections, and gonococcal urethritis. It works against a broad range of Gram‑negative and Gram‑positive bacteria that are susceptible to fluoroquinolones.

Ofloxacin inhibits bacterial DNA gyrase (topoisomerase II) and topoisomerase IV, enzymes that are essential for DNA replication, transcription and repair. By binding to these enzymes, it prevents the resealing of DNA strands, causing accumulation of double‑strand breaks and ultimately leading to bacterial cell death.

The dosage of Ofloxacin Ud Stulln is determined by the prescribing healthcare professional based on the type and severity of the infection, patient age, renal function and other clinical factors. Prescribers set the appropriate strength, frequency and duration of therapy for each individual case.

Ofloxacin is classified as a pregnancy category C drug, meaning that risk to the fetus cannot be ruled out and it should only be used when the potential benefits justify the potential risks. Limited data are available for breastfeeding; the drug does pass into breast milk, so a decision should be made by the prescriber after weighing maternal benefits against possible infant exposure.

To place an order, submit an enquiry on the product page at gnhindia.com specifying the required quantity of Ofloxacin Ud Stulln. GNH India supplies hospitals, pharmacies and procurement teams worldwide, and will request verification of trade or institutional credentials. After confirmation, the sales team provides pricing, availability, shipping details (including any cold‑chain requirements) and assists with import documentation.

Ofloxacin shares the same fluoroquinolone class as ciprofloxacin and levofloxacin, offering a broad spectrum against Gram‑negative and Gram‑positive organisms. Compared with ciprofloxacin, Ofloxacin often provides similar efficacy with a slightly different dosing schedule and may have a lower propensity for certain drug‑interaction risks. Choice between agents depends on local resistance patterns, patient tolerance and prescriber preference.

Ofloxacin Ud Stulln tablets should be stored below 25 °C in a dry environment. Keep the product in its original packaging to protect it from moisture and light. Do not store in the bathroom or near heat sources, and ensure the container is tightly closed when not in use.

The medication is supplied as oral tablets and should be taken with a full glass of water. It can be taken with or without food, but patients should avoid simultaneous intake of antacids containing magnesium or aluminum, as these can reduce absorption. The prescriber will advise the exact dosing schedule.

Serious adverse events include tendon rupture (especially of the Achilles tendon), QT interval prolongation that may lead to cardiac arrhythmias, and severe allergic reactions such as anaphylaxis. Patients should seek immediate medical attention if they experience sudden tendon pain, palpitations, fainting, or signs of a severe allergic response.

Ofloxacin Ud Stulln is contraindicated in patients with a known hypersensitivity to fluoroquinolones or any of the tablet excipients. It should also be avoided in individuals with a history of tendon disorders related to fluoroquinolone use, and in patients taking medications that significantly prolong the QT interval unless the benefits outweigh the risks.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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