Ofloxacine 200 Pch (Ofloxacin)

Ofloxacin is a broad‑spectrum fluoroquinolone antibiotic used to treat infections caused by susceptible bacteria.

• Uncomplicated urinary tract infection: eradicates the causative uropathogens and resolves symptoms.
• Acute bacterial sinusitis: reduces bacterial load and improves sinus drainage.
• Skin and soft‑tissue infections: eliminates common Gram‑negative and Gram‑positive organisms.
• Community‑acquired pneumonia: targets typical respiratory pathogens.
• Gonorrhea (single‑dose therapy): provides rapid bacterial clearance.

• Ofloxacin inhibits bacterial DNA gyrase and topoisomerase IV, enzymes essential for DNA replication, transcription, and repair. By binding to these enzymes, it prevents the supercoiling and separation of DNA strands, leading to bacterial cell death and a bactericidal effect against susceptible organisms.

Adverse reactions may occur with Ofloxacin use.

Common Side Effects

• Nausea: mild to moderate gastrointestinal upset.
• Diarrhea: loose stools, occasionally watery.
• Headache: transient cranial discomfort.
• Dizziness: occasional vertiginous sensation.
• Photosensitivity: increased skin sensitivity to sunlight.
• Rash: mild erythematous skin eruptions.

Serious or Rare Side Effects

• Tendon rupture: sudden pain and loss of function, especially in the Achilles.
• QT interval prolongation: risk of cardiac arrhythmias.
• Central nervous system effects: seizures, confusion, or hallucinations.
• Severe allergic reactions: anaphylaxis, angioedema, or Stevens‑Johnson syndrome.
• Hepatotoxicity: elevated liver enzymes or jaundice.
• Peripheral neuropathy: tingling or numbness in extremities.

Before prescribing Ofloxacin, consider patient-specific factors and safety measures.

• Renal impairment: adjust dose or monitor renal function.
• History of tendon disorders: avoid use in patients with prior tendon injury.
• Cardiac risk: caution in patients with known QT prolongation.
• Pregnancy and lactation: use only if clearly needed, after risk‑benefit assessment.
• Concomitant medications: review for potential interactions that may affect cardiac rhythm.
• Store at ambient temperature: keep below 25 °C, in the original container, protected from moisture and direct sunlight.

Ofloxacin may interact with other medicines, requiring monitoring or avoidance.

Major Interactions (Avoid)

• Antacids containing aluminum or magnesium: reduce Ofloxacin absorption.
• Non‑steroidal anti‑inflammatory drugs (NSAIDs): increase risk of CNS stimulation.
• Warfarin: may enhance anticoagulant effect, requiring INR monitoring.

Moderate Interactions (Monitor Closely)

• Corticosteroids: heightened risk of tendon rupture.
• Cyclosporine: may increase serum levels of Ofloxacin.
• Theophylline: potential for increased plasma concentrations and toxicity.