Ofloxacine 400 Pch (Ofloxacin)

Ofloxacin is a fluoroquinolone antibiotic that interferes with bacterial DNA replication, making it effective for several common bacterial infections.

• Urinary tract infection: eradicates susceptible uropathogens and resolves urinary symptoms.
• Respiratory tract infection: treats acute exacerbations of chronic bronchitis and community‑acquired pneumonia caused by susceptible bacteria.
• Skin and soft‑tissue infection: clears infections such as cellulitis and impetigo.
• Sexually transmitted infection (gonorrhoea): eliminates Neisseria gonorrhoeae strains sensitive to ofloxacin.
• Traveler's diarrhea: combats bacterial causes of acute diarrhoea acquired abroad.

• Ofloxacin inhibits bacterial DNA gyrase (topoisomerase II) and topoisomerase IV, enzymes essential for DNA supercoiling and replication. By binding to these enzymes, it prevents the unwinding and resealing of DNA strands, halting bacterial cell division and leading to bacterial cell death. This bactericidal action is effective against a broad spectrum of Gram‑negative and Gram‑positive organisms.

Common side effects are generally mild and self‑limiting.

Common Side Effects

• Nausea: transient stomach upset.
• Diarrhoea: loose stools occurring during therapy.
• Headache: mild to moderate intensity.
• Dizziness: occasional light‑headed feeling.
• Abdominal pain: cramping or discomfort.
• Rash: mild skin irritation.

Serious or Rare Side Effects

• Tendon rupture: sudden pain and loss of function, especially in the Achilles tendon.
• QT interval prolongation: risk of cardiac arrhythmias.
• Severe allergic reactions: anaphylaxis, angioedema, or bronchospasm.
• Clostridioides difficile colitis: severe diarrhoea due to gut flora disruption.
• Peripheral neuropathy: tingling or numbness in extremities.
• Stevens‑Johnson syndrome: severe skin and mucous membrane reactions.

Before prescribing Ofloxacine, clinicians should consider several safety factors.

• Assess renal function: adjust dose in patients with impaired clearance.
• Avoid in patients with known hypersensitivity to fluoroquinolones.
• Monitor for tendon pain: discontinue immediately if tendinitis or rupture occurs.
• Use with caution in pregnancy or breastfeeding: safety data are limited.
• Avoid concurrent use with other QT‑prolonging agents: evaluate cardiac risk.
• Store at ambient temperature below 25°C: keep in the original container, protect from moisture and light.

Ofloxacin may interact with several medicines, requiring attention to avoid adverse outcomes.

Major Interactions (Avoid)

• Tizanidine: co‑administration can cause marked hypotension and sedation.
• Drugs that prolong QT interval (e.g., macrolides, other fluoroquinolones): increased risk of arrhythmia.
• Antacids containing magnesium or aluminum, and sucralfate: reduce ofloxacin absorption.

Moderate Interactions (Monitor Closely)

• Corticosteroids: heightened risk of tendon rupture; monitor musculoskeletal symptoms.
• NSAIDs: may amplify central nervous system effects such as dizziness.
• Warfarin: potential enhancement of anticoagulant effect; check INR regularly.