Product image of Ofloxacine Aguettant (Ofloxacin) supplied by GNH India

Ofloxacine Aguettant

Active Ingredient:
Ofloxacin
Origin:
EU

Ofloxacine Aguettant (Ofloxacin)

Ofloxacin, the active ingredient in Ofloxacine Aguettant, is a fluoroquinolone presented as an injectable solution for intravenous use. It is indicated for the treatment of serious Gram‑negative bacterial infections, such as respiratory tract, urinary tract, and skin and soft‑tissue infections, in adult patients.

GNH India supplies Ofloxacine Aguettant as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide, providing EU‑approved quality for global distribution. The product complies with EU pharmacopoeial standards and is manufactured under GMP conditions, ensuring safety and efficacy.

Manufacturer / TM Owner

Laboratoire Aguettant

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Indications & Clinical Uses

Ofloxacine Aguettant (ofloxacin) is a fluoroquinolone antibiotic used to treat infections caused by Gram‑negative bacteria.

  • Respiratory tract infections: effective in treating pneumonia and bronchitis caused by susceptible Gram‑negative organisms.
  • Urinary tract infections: used for acute cystitis and pyelonephritis due to susceptible strains.
  • Skin and soft tissue infections: indicated for cellulitis and wound infections resulting from Gram‑negative pathogens.
  • Severe intra‑abdominal infections: employed as part of combination therapy for complicated intra‑abdominal infections.

How It Works

  • Ofloxacin exerts its antibacterial effect by binding to the bacterial enzymes DNA gyrase (topoisomerase II) and topoisomerase IV. Inhibition of these enzymes prevents the supercoiling and separation of DNA strands required for replication and transcription, leading to bactericidal activity against susceptible Gram‑negative and some Gram‑positive organisms. The drug penetrates well into respiratory, urinary and tissue fluids, achieving concentrations above the minimum inhibitory concentration for target pathogens.

Side Effects

Ofloxacine Aguettant may be associated with a range of adverse reactions, which are categorized by frequency and severity.

Common Side Effects

  • Nausea
  • Diarrhea
  • Headache
  • Dizziness
  • Injection site pain
  • Elevated liver enzymes

Serious or Rare Side Effects

  • Tendon rupture or tendinitis
  • QT interval prolongation
  • Severe allergic reactions (anaphylaxis)
  • Clostridioides difficile‑associated diarrhea
  • Peripheral neuropathy
  • Hepatic failure

Precautions & Warnings

When using Ofloxacine Aguettant, clinicians should consider several precautionary measures.

  • Renal function: adjust dose in patients with impaired renal clearance.
  • Hepatic function: use with caution in severe liver disease.
  • Pregnancy: classified B1, use only if the benefit outweighs the potential risk.
  • Tendon safety: discontinue if tendon pain, swelling, or inflammation occurs.
  • Hypersensitivity: avoid in patients with known fluoroquinolone allergy.
  • Store at 2-8°C: keep refrigerated, protect from light, do not freeze.

Avoid Interactions

Ofloxacine Aguettant can interact with other medicines; some interactions require avoidance while others need monitoring.

Major Interactions (Avoid)

  • Antacids or supplements containing divalent cations (magnesium, aluminum, calcium): reduce ofloxacin absorption.
  • Warfarin: may increase anticoagulant effect and INR, raising bleeding risk.
  • Theophylline: increased plasma concentrations can lead to toxicity.

Moderate Interactions (Monitor Closely)

  • NSAIDs: may increase the risk of central nervous system effects such as seizures.
  • Corticosteroids: combined use may raise the risk of tendon rupture.

Frequently Asked Questions

Ofloxacine Aguettant contains ofloxacin, a fluoroquinolone antibiotic indicated for the treatment of serious Gram‑negative bacterial infections, including respiratory tract infections, urinary tract infections, and skin and soft‑tissue infections in adult patients.

Ofloxacin inhibits bacterial DNA gyrase and topoisomerase IV, enzymes essential for DNA replication and transcription. By blocking these targets, the drug prevents bacterial cell division and leads to a bactericidal effect against susceptible organisms.

The dosage and duration of therapy are determined by the prescribing clinician based on the type and severity of infection, patient weight, renal function, and local antimicrobial guidelines. No fixed regimen is provided here.

Ofloxacin is classified as pregnancy category B1, indicating that animal studies have not shown risk and there are no adequate human studies. It should be used only when the potential benefit justifies any potential risk to the fetus. Limited data are available for breastfeeding, so clinical judgment is required.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India supplies hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including cold‑chain where required) and necessary import documentation.

Ofloxacin offers a broad spectrum against Gram‑negative pathogens and has good tissue penetration, similar to ciprofloxacin and levofloxacin. Compared with ciprofloxacin, ofloxacin may have slightly higher activity against certain respiratory isolates, while levofloxacin provides once‑daily dosing. Choice depends on local resistance patterns, dosing convenience and patient‑specific factors.

The injectable solution should be stored at 2‑8 °C, protected from light, and must not be frozen or shaken. Keep the product in its original packaging until use to maintain stability and sterility.

Ofloxacine Aguettant is given by intravenous infusion. The infusion rate and dilution volume are determined by the prescriber and nursing staff, following aseptic technique and institutional protocols for IV administration.

Serious adverse events include tendon rupture or tendinitis, QT interval prolongation leading to arrhythmias, severe allergic reactions such as anaphylaxis, Clostridioides difficile‑associated colitis, peripheral neuropathy, and hepatic failure. Patients should be monitored closely for any signs of these conditions.

Patients with a known hypersensitivity to ofloxacin, other fluoroquinolones, or any component of the formulation should avoid this product. Caution is also advised in individuals with a history of tendon disorders, uncontrolled cardiac arrhythmias, or severe renal/hepatic impairment.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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