Ofloxacine Teva (Ofloxacin)

Ofloxacin is a broad‑spectrum fluoroquinolone used to treat infections of several organ systems.

• Uncomplicated urinary tract infection: eradicates susceptible uropathogens and resolves dysuria and frequency.
• Acute bacterial sinusitis: eliminates the causative bacteria and improves sinus drainage.
• Acute exacerbation of chronic bronchitis: reduces bacterial load and eases cough and sputum production.
• Skin and soft‑tissue infection: clears susceptible Staphylococcus and Streptococcus species, promoting wound healing.
• Gonorrhea: rapidly kills Neisseria gonorrhoeae, preventing disease progression.

• Ofloxacin inhibits bacterial DNA gyrase and topoisomerase IV, enzymes essential for DNA replication, transcription, and repair. By binding to these enzymes, it prevents the supercoiling and relaxation of bacterial DNA, leading to inhibition of bacterial cell division and ultimately bacterial death. The drug exhibits concentration‑dependent bactericidal activity against a wide range of Gram‑negative and Gram‑positive organisms.

Common Side Effects

• Nausea: mild to moderate upset stomach.
• Diarrhea: loose stools, sometimes watery.
• Headache: transient cranial discomfort.
• Dizziness: occasional light‑headed sensation.
• Abdominal pain: cramping or discomfort.
• Rash: mild skin erythema.

Serious or Rare Side Effects

• Tendon rupture: sudden pain and loss of function, especially in the Achilles tendon.
• QT interval prolongation: may lead to cardiac arrhythmias.
• Severe allergic reactions: anaphylaxis, angioedema, or bronchospasm.
• Clostridioides difficile‑associated diarrhea: severe colitis requiring medical attention.
• Stevens‑Johnson syndrome: extensive skin blistering and mucosal involvement.
• Hepatic dysfunction: elevated liver enzymes or jaundice.

Before initiating therapy, clinicians should evaluate patient‑specific risk factors and monitor for adverse events.

• Assess renal function: adjust dosing in patients with impaired clearance.
• Avoid in patients with known hypersensitivity to fluoroquinolones.
• Monitor for tendon pain or inflammation: discontinue if tendonitis or rupture occurs.
• Use with caution during pregnancy or lactation: only if benefits outweigh potential risks.
• Store at ambient temperature below 25°C: keep in the original pack, protect from moisture.

Ofloxacine Teva may interact with several medicines; careful review is required.

Major Interactions (Avoid)

• Antacids containing magnesium or aluminum: markedly reduce ofloxacin absorption.
• Tizanidine: co‑administration can cause profound hypotension and sedation.
• Warfarin: may potentiate anticoagulant effect and increase bleeding risk.
• Concurrent use with other fluoroquinolones: additive toxicity, especially tendon and CNS effects.

Moderate Interactions (Monitor Closely)

• NSAIDs: may increase central nervous system stimulation and seizure risk.
• Theophylline: ofloxacin can raise plasma theophylline concentrations, requiring dose adjustment.
• Ciprofloxacin: combined use may enhance QT‑interval prolongation.