Ofloxamed (Ofloxacin)

Ofloxamed is indicated for bacterial eye infections, targeting pathogens that cause conjunctival and corneal disease.

• Bacterial conjunctivitis: reduces bacterial load and resolves infection of the conjunctiva.
• Keratitis: eliminates causative bacteria and promotes healing of the corneal epithelium.
• Other ocular bacterial infections: provides broad‑spectrum coverage to treat bacterial involvement of the eyelid, sclera or intra‑ocular structures.

• Ofloxacin exerts its antibacterial effect by binding to the bacterial enzymes DNA gyrase (topoisomerase II) and topoisomerase IV. Inhibition of these enzymes prevents supercoiling and separation of bacterial DNA during replication and transcription, leading to bactericidal activity against a wide range of Gram‑negative and Gram‑positive ocular pathogens.

Topical ofloxacin may cause local ocular reactions as well as rare systemic or severe ocular events.

Common Side Effects

• Eye irritation: transient burning or stinging upon instillation.
• Redness: mild conjunctival hyperemia.
• Tearing: increased lacrimation.
• Blurred vision: temporary visual disturbance.
• Foreign body sensation: feeling of grit in the eye.

Serious or Rare Side Effects

• Allergic reaction: swelling, itching, or rash requiring discontinuation.
• Corneal ulceration: worsening of corneal lesions or perforation.
• Severe eye pain: intense discomfort indicating possible toxicity.
• Vision loss: sudden decrease in visual acuity.
• Stevens‑Johnson syndrome: rare systemic hypersensitivity affecting skin and mucosa.

When using Ofloxamed, clinicians should observe several precautionary measures to ensure safety and effectiveness.

• Allergy assessment: avoid use in patients with known hypersensitivity to fluoroquinolones.
• Contact lens use: discontinue lenses during treatment to prevent drug absorption interference.
• Systemic exposure: monitor for systemic fluoroquinolone effects if used on large ocular surfaces or for prolonged periods.
• Pregnancy and lactation: use only if clearly needed, as safety has not been established.
• Drug interactions: avoid concurrent use with other ophthalmic antibiotics without professional guidance.
• Store at room temperature: keep in original container, protect from light and moisture.

Ofloxamed may interact with other medications, particularly when systemic fluoroquinolones or ocular agents are used concurrently.

Major Interactions (Avoid)

• Systemic fluoroquinolones: concurrent use may increase systemic exposure and risk of tendon toxicity.
• Topical corticosteroids: may mask infection signs and delay healing.
• Anticholinergic eye drops: may reduce ofloxacin absorption and efficacy.

Moderate Interactions (Monitor Closely)

• Nonsteroidal anti‑inflammatory eye drops: may increase ocular irritation.
• Other topical antibiotics: may cause additive toxicity or antagonism.
• Herbal supplements containing quinine: potential additive QT‑prolongation risk.