Product image of Ofloxavis (Ofloxacin) supplied by GNH India

Ofloxavis

Active Ingredient:
Ofloxacin
Origin:
EU

Ofloxavis (Ofloxacin)

Ofloxacin, the active ingredient in Ofloxavis, is a fluoroquinolone antibiotic presented as an ophthalmic solution for ocular use. It provides broad‑spectrum activity against Gram‑negative and Gram‑positive bacteria that cause eye infections, and it is indicated for conditions such as bacterial conjunctivitis and keratitis in both adult and pediatric patients.

GNH India supplies Ofloxavis as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide, with distribution across EU and other global markets.

Manufacturer / TM Owner

Pharma Stulln Gmbh

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Indications & Clinical Uses

  • Ofloxavis (ofloxacin) is used to treat bacterial eye infections by targeting the underlying pathogens.
  • Bacterial conjunctivitis: reduces bacterial load and resolves redness, discharge, and irritation.
  • Bacterial keratitis: eradicates causative organisms and promotes corneal healing.
  • Other ocular bacterial infections: controls infection in conditions such as blepharitis and corneal ulceration.

How It Works

  • Ofloxacin exerts its antibacterial effect by binding to bacterial DNA gyrase and topoisomerase IV, enzymes essential for DNA supercoiling and replication. Inhibition of these enzymes prevents DNA synthesis and transcription, leading to bacterial cell death. This mechanism is effective when the drug is applied directly to the eye surface, achieving high local concentrations.

Side Effects

Ocular administration of Ofloxavis may be associated with a range of adverse reactions, most of which are mild and transient.

Common Side Effects

  • Stinging or burning sensation upon instillation.
  • Temporary blurred vision.
  • Redness of the conjunctiva.
  • Mild itching or irritation.

Serious or Rare Side Effects

  • Allergic reactions such as eyelid swelling, rash, or hives.
  • Corneal ulceration or perforation.
  • Severe eye pain or sudden loss of vision.
  • Anaphylactic shock (rare).

Precautions & Warnings

Before using Ofloxavis, certain precautions should be observed to ensure safety and therapeutic effectiveness.

  • Allergy assessment: avoid if patient has known hypersensitivity to fluoroquinolones or any component of the eye drops.
  • Prescription adherence: use only the dosage and duration prescribed by a qualified eye care professional.
  • Infection monitoring: discontinue and seek medical advice if symptoms worsen or fail to improve within the expected time.
  • Contact lens use: remove contact lenses during treatment and avoid reinsertion until therapy is completed.
  • Corneal integrity: do not use in eyes with perforated cornea or severe epithelial defects.
  • Store at room temperature: keep the bottle in its original packaging, protect from light and moisture, and do not freeze.

Avoid Interactions

Ofloxavis can interact with other medications, affecting either its efficacy or safety profile.

Major Interactions (Avoid)

  • Systemic fluoroquinolones: concurrent use may increase risk of tendon rupture and other systemic fluoroquinolone adverse effects.
  • Topical corticosteroids: may mask signs of infection and delay healing.
  • Anticholinergic eye drops: can reduce tear production, potentially worsening ocular irritation.

Moderate Interactions (Monitor Closely)

  • Antihistamine eye drops: may increase ocular dryness when used together.
  • Contact lens cleaning solutions: certain preservatives can cause irritation when combined with Ofloxavis.
  • Non‑steroidal anti‑inflammatory eye drops: may slightly alter drug absorption.

Frequently Asked Questions

Ofloxavis is an ophthalmic preparation containing ofloxacin that is prescribed to treat bacterial infections of the eye. It is indicated for conditions such as bacterial conjunctivitis, bacterial keratitis, and other ocular bacterial infections where a broad‑spectrum fluoroquinolone is appropriate.

Ofloxacin belongs to the fluoroquinolone class and works by inhibiting bacterial DNA gyrase and topoisomerase IV. These enzymes are essential for DNA replication and transcription, so their blockade leads to bacterial cell death and helps clear the infection from the ocular surface.

The dosing regimen for Ofloxavis is determined by the prescribing eye‑care professional based on the specific infection, severity, and patient age. The prescriber will provide exact instructions on the number of drops, frequency, and duration of therapy.

Safety data for ocular ofloxacin in pregnancy and lactation are limited. The drug should only be used if the potential benefit justifies any possible risk to the fetus or infant, and the decision should be made by the treating physician in consultation with the patient.

To request Ofloxavis, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India supplies hospitals, pharmacies and procurement teams worldwide, and will verify trade or institutional credentials before providing pricing, availability, shipping details and any necessary import documentation.

Ofloxavis (ofloxacin) offers broad‑spectrum coverage against Gram‑negative and Gram‑positive bacteria, similar to other fluoroquinolone eye drops such as ciprofloxacin. Compared with macrolide or aminoglycoside ophthalmic agents, ofloxacin generally provides faster bacterial eradication and a convenient dosing schedule, but the choice depends on local resistance patterns and patient tolerance.

Store Ofloxavis at room temperature, preferably below 25 °C, in its original container. Keep the bottle tightly closed, protect it from light and moisture, and avoid freezing. Do not refrigerate unless specifically instructed by the supplier.

The eye drops are instilled directly onto the affected eye(s) as directed by the prescriber, typically one to two drops per dose. Patients should wash their hands before use, avoid touching the tip of the bottle to the eye or any surface, and follow the prescribed frequency and duration.

Serious adverse reactions, although rare, include severe allergic responses such as eyelid swelling, rash, hives, or anaphylaxis, as well as corneal ulceration or perforation that can threaten vision. Any sudden increase in eye pain, loss of vision, or signs of a severe reaction should prompt immediate medical attention.

Ofloxavis should be avoided in patients with a known hypersensitivity to fluoroquinolones or any excipients in the formulation. It is also contraindicated in eyes with perforated corneas, severe epithelial defects, or in individuals where the risk of tendon disorders is heightened due to systemic fluoroquinolone exposure.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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