Product image of Ofloxin- 400 (Ofloxacin) 400mg Tablet supplied by GNH India

Ofloxin- 400

Active Ingredient:
Ofloxacin
Form:
Tablet
Brand:
Ofloxin- 400
Origin:
India

Ofloxin- 400 (Ofloxacin Tablet) 400mg

Ofloxacin, the active ingredient in Ofloxin-400, is a fluoroquinolone presented as a 400mg tablet for oral use. It is used to treat bacterial infections in adults, including urinary tract infections, respiratory infections, and skin and soft tissue infections. GNH India supplies Ofloxin-400 as a licensed, GDP-compliant international pharmaceutical supplier serving hospitals, pharmacies, and clinics worldwide.

Ofloxin-400 is a trusted antibiotic that effectively targets a range of bacterial infections. Its broad-spectrum activity makes it a valuable tool in the management of various bacterial conditions.

Strength

400mg

Manufacturer / TM Owner

Theon Pharmaceuticals Ltd

1
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Indications & Clinical Uses

Ofloxin-400 is used to treat bacterial infections. It is effective in managing various conditions, including:

  • Urinary tract infections: Treats infections in the urinary system, including uncomplicated and complicated urinary tract infections and pyelonephritis.
  • Respiratory infections: Used to manage community-acquired pneumonia and other respiratory tract infections.
  • Skin and soft tissue infections: Effective in treating infections of the skin and soft tissues.
  • Sexually transmitted infections: Treats infections such as gonorrhoea and chlamydia.
  • Bone and joint infections: Used in the management of osteomyelitis and other bone and joint infections.

How It Works

  • Ofloxin-400 works by inhibiting bacterial DNA gyrase and topoisomerase IV, enzymes essential for DNA replication and repair. By binding to these enzymes, ofloxacin prevents the bacteria from replicating and repairing their DNA, leading to their death. This mechanism makes it effective against a wide range of bacterial infections.

Side Effects

Ofloxin-400 may cause side effects, although not everyone gets them. Common Side Effects:

  • Nausea and vomiting
  • Diarrhoea
  • Headache
  • Dizziness
  • Insomnia
  • Rash
  • Elevated liver enzymes

Serious or Rare Side Effects

  • Tendinitis or tendon rupture
  • Peripheral neuropathy
  • Severe central nervous system effects, such as seizures, hallucinations, and psychosis
  • Clostridium difficile colitis
  • Hepatotoxicity
  • Haemolytic anaemia
  • Agranulocytosis
  • Torsades de pointes
  • Anaphylaxis
  • Stevens-Johnson syndrome

Precautions & Warnings

Ofloxin-400 should be used with caution in certain populations and conditions. Precautions include:

  • Hypersensitivity: Avoid use in patients with a known hypersensitivity to ofloxacin or other fluoroquinolones.
  • QT prolongation: Use with caution in patients with a history of QT prolongation or those taking QT-prolonging drugs.
  • Tendon disorders: Avoid use in patients with a history of tendon disorders related to fluoroquinolone use.
  • Seizure disorders: Use with caution in patients with epilepsy or other seizure disorders.
  • Pregnancy and breastfeeding: Consult a doctor before use during pregnancy or breastfeeding.
  • Children and adolescents: Not recommended for use in children and adolescents under 18 years of age.
  • Store below 30°C: Keep in the original pack, protect from moisture.

Avoid Interactions

Ofloxin-400 may interact with other medications, potentially altering their effects or increasing the risk of side effects. Major Interactions (Avoid):

  • QT-prolonging drugs: Avoid concurrent use to prevent QT prolongation and arrhythmias.
  • Corticosteroids: Avoid concurrent use to prevent tendon rupture.
  • Non-steroidal anti-inflammatory drugs (NSAIDs): Avoid concurrent use to prevent seizures.

Moderate Interactions (Monitor Closely)

  • Antacids: Monitor for reduced absorption of ofloxacin.
  • Probenecid: Monitor for increased ofloxacin levels and potential side effects.
  • Warfarin: Monitor for increased anticoagulant effects and bleeding risk.
  • Cyclosporine: Monitor for increased ofloxacin levels and potential side effects.

Frequently Asked Questions

Ofloxin-400 is used to treat a variety of bacterial infections, including urinary tract infections, respiratory infections, skin and soft tissue infections, sexually transmitted infections, and bone and joint infections. It is effective against a wide range of bacteria and is prescribed by healthcare professionals to manage these conditions.

Ofloxacin works by inhibiting bacterial DNA gyrase and topoisomerase IV, enzymes essential for DNA replication and repair. By binding to these enzymes, ofloxacin prevents the bacteria from replicating and repairing their DNA, leading to their death. This mechanism makes it effective against a wide range of bacterial infections.

The dosage of Ofloxin-400 is determined by a healthcare professional based on the type and severity of the infection, as well as the patient's age, weight, and overall health. It is important to follow the prescribed dosage and complete the full course of treatment, even if symptoms improve.

The safety of Ofloxin-400 during pregnancy or breastfeeding has not been established. It is important to consult a healthcare professional before using this medication if you are pregnant, planning to become pregnant, or breastfeeding. They can provide guidance based on your specific situation.

To order Ofloxin-400 from GNH India, submit an enquiry on the product page at gnhindia.com with the required quantity. GNH India supplies hospitals, pharmacies, and procurement teams across international markets. The team will ask you to confirm your trade or institutional credentials and will reply with pricing, availability, shipping, and the import paperwork.

Ofloxin-400 is a fluoroquinolone antibiotic with a broad spectrum of activity against various bacteria. It is often compared to other fluoroquinolones like ciprofloxacin and levofloxacin. The choice of antibiotic depends on the specific infection, local resistance patterns, and the patient's medical history. Consult a healthcare professional for the most appropriate treatment.

Ofloxin-400 should be stored below 30°C, in the original pack, and protected from moisture. It is important to keep the medication out of reach of children and to follow the storage instructions provided on the packaging. Proper storage ensures the effectiveness and safety of the medication.

Ofloxin-400 is administered orally in the form of tablets. It should be taken with a glass of water, with or without food, preferably at a fixed time. It is important to follow the dosage instructions provided by your healthcare professional and to complete the full course of treatment, even if symptoms improve.

The most serious risks associated with Ofloxin-400 include tendinitis or tendon rupture, peripheral neuropathy, severe central nervous system effects such as seizures, hallucinations, and psychosis, Clostridium difficile colitis, hepatotoxicity, haemolytic anaemia, agranulocytosis, torsades de pointes, anaphylaxis, and Stevens-Johnson syndrome. If you experience any of these symptoms, seek medical attention immediately.

Ofloxin-400 should not be used by individuals with a known hypersensitivity to ofloxacin or other fluoroquinolones, those with a history of tendon disorders related to fluoroquinolone use, patients with epilepsy or other seizure disorders, children and adolescents under 18 years of age, and pregnant or breastfeeding women unless specifically advised by a healthcare professional.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

References

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