Product image of Ofloxin (Ofloxacin) supplied by GNH India

Ofloxin

Active Ingredient:
Ofloxacin
Origin:
EU

Ofloxin (Ofloxacin)

Ofloxacin, the active ingredient in Ofloxin, is a fluoroquinolone presented as an oral tablet for systemic use. It treats bacterial infections in adults and children when prescribed, targeting a range of urinary, respiratory, skin, prostate and sexually transmitted infections. It is effective against a broad spectrum of Gram‑negative and Gram‑positive bacteria.

GNH India supplies Ofloxin as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide, with quality assurance, regulatory compliance and reliable logistics for global distribution, ensuring consistent supply and adherence to international pharmacopeial standards.

Manufacturer / TM Owner

Zentiva, K.S.

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Indications & Clinical Uses

Ofloxin (ofloxacin) is a fluoroquinolone antibacterial used to treat infections in various organ systems.

  • Urinary tract infection: eradicates susceptible bacteria, relieving symptoms and preventing complications.
  • Respiratory tract infection: treats acute infections such as bronchitis and pneumonia caused by susceptible organisms.
  • Skin and soft tissue infection: resolves cellulitis, abscesses and wound infections due to susceptible pathogens.
  • Prostatitis: eliminates bacterial infection of the prostate, improving urinary function and pain.
  • Sexually transmitted infections: combats infections like gonorrhea caused by susceptible strains.

How It Works

  • Ofloxacin exerts its antibacterial activity by binding to bacterial DNA gyrase (topoisomerase II) and topoisomerase IV, enzymes essential for DNA supercoiling and replication. Inhibition of these enzymes prevents DNA synthesis and transcription, leading to bacterial cell death. The drug shows concentration‑dependent killing against a broad range of Gram‑negative and Gram‑positive organisms, and is effective at clinically achievable concentrations. This mechanism underlies its broad‑spectrum activity.

Side Effects

Ofloxin may be associated with a range of adverse reactions, varying from mild to serious.

Common Side Effects

  • Nausea: mild to moderate stomach upset.
  • Diarrhea: loose stools, sometimes watery.
  • Headache: mild to moderate intensity.
  • Dizziness: transient light‑headedness.
  • Abdominal pain: cramping or discomfort.
  • Rash: mild skin erythema.

Serious or Rare Side Effects

  • Tendon rupture: especially Achilles, requiring immediate medical attention.
  • QT interval prolongation: may lead to cardiac arrhythmias.
  • Severe allergic reactions: including anaphylaxis, angioedema.
  • Clostridioides difficile infection: severe colitis.
  • Hepatic dysfunction: elevated liver enzymes or hepatitis.
  • Peripheral neuropathy: numbness or tingling in extremities.

Precautions & Warnings

When prescribing Ofloxin, clinicians should consider several safety aspects.

  • Renal impairment: adjust dose as recommended by the prescriber.
  • History of tendon disorders: avoid use or monitor closely for tendon pain.
  • QT prolongation risk: avoid in patients with known cardiac arrhythmias.
  • Pregnancy and lactation: use only if benefits outweigh potential risks.
  • Drug interactions: review concomitant medications for potential interactions.
  • Store at ambient temperature: keep below 25 °C, in original packaging, protected from moisture.

Avoid Interactions

Ofloxin can interact with other medicines, requiring careful management.

Major Interactions (Avoid)

  • Antacids containing aluminum, magnesium, calcium, or iron: may markedly reduce ofloxacin absorption.
  • Warfarin: may enhance anticoagulant effect, increasing bleeding risk.
  • Other QT‑prolonging agents: combined use can increase risk of serious cardiac arrhythmias.

Moderate Interactions (Monitor Closely)

  • Non‑steroidal anti‑inflammatory drugs (NSAIDs): may increase risk of central nervous system stimulation.
  • CYP450 inducers such as rifampin: may lower ofloxacin plasma concentrations, reducing efficacy.

Frequently Asked Questions

Ofloxin contains ofloxacin, a fluoroquinolone antibiotic that is prescribed for a variety of bacterial infections, including urinary tract infections, respiratory tract infections such as bronchitis and pneumonia, skin and soft‑tissue infections, prostatitis, and certain sexually transmitted infections caused by susceptible organisms.

Ofloxacin works by binding to bacterial enzymes DNA gyrase and topoisomerase IV, which are essential for DNA replication and transcription. Inhibiting these enzymes prevents bacterial DNA synthesis, leading to bacterial cell death and a reduction in the infection.

The dosage of Ofloxin is determined by the prescribing clinician based on the type and severity of the infection, patient age, kidney function and other clinical factors. Only a qualified health‑care professional should set the dose and treatment duration.

The safety of Ofloxin in pregnancy and lactation has not been definitively established. It should be used only if the potential benefit justifies the potential risk to the fetus or infant, and the decision should be made by a health‑care provider.

To request Ofloxin, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any required import documentation.

Ofloxin (ofloxacin) shares the class‑wide mechanism of DNA gyrase inhibition with other fluoroquinolones but differs in its pharmacokinetic profile, spectrum of activity and tissue penetration. Compared with agents such as ciprofloxacin, ofloxacin often offers similar efficacy with a slightly broader Gram‑positive coverage, though individual choice depends on susceptibility patterns and patient factors.

Ofloxin tablets should be stored at ambient temperature, preferably below 25 °C. Keep the medication in its original packaging, protect it from moisture and direct sunlight, and store it out of reach of children.

Ofloxin is supplied as oral tablets that are taken by mouth with a full glass of water. It may be taken with or without food, but absorption can be reduced if taken simultaneously with antacids or supplements containing calcium, magnesium, aluminum or iron.

Serious adverse events linked to Ofloxin include tendon rupture (especially Achilles), QT‑interval prolongation leading to cardiac arrhythmias, severe allergic reactions such as anaphylaxis, Clostridioides difficile‑associated colitis, hepatic injury and peripheral neuropathy. Patients should seek immediate medical attention if they experience sudden tendon pain, palpitations, severe rash or neurological symptoms.

Ofloxin is contraindicated in patients with a known hypersensitivity to ofloxacin or other fluoroquinolones. It should also be avoided in individuals with a history of tendon disorders related to fluoroquinolone use, those with significant QT‑prolongation, and patients receiving concomitant therapy that markedly increases the risk of tendon rupture or cardiac arrhythmias.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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