Product image of Oftacilox (Ciprofloxacin Hydrochloride) supplied by GNH India

Oftacilox

Active Ingredient:
Ciprofloxacin Hydrochloride
Origin:
EU

Oftacilox (Ciprofloxacin Hydrochloride)

Ciprofloxacin, the active ingredient in Oftacilox, is a fluoroquinolone antibiotic presented as an ophthalmic solution for topical ocular use. It provides broad‑spectrum coverage against Gram‑negative and Gram‑positive bacteria that cause eye infections, and is indicated for the treatment of bacterial conjunctivitis, keratitis, and other superficial ocular infections in both adult and pediatric patients.

GNH India supplies Oftacilox as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Davi Ii - Farmacêutica, S.A.

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Indications & Clinical Uses

Oftacilox (ciprofloxacin) is an ophthalmic fluoroquinolone used to treat bacterial infections of the eye.

  • Bacterial conjunctivitis: reduces bacterial load and resolves inflammation of the conjunctiva.
  • Bacterial keratitis: eradicates causative organisms and promotes corneal healing.
  • Post‑operative ocular prophylaxis: prevents infection after eye surgery or invasive procedures.

How It Works

  • Ciprofloxacin inhibits bacterial DNA gyrase (topoisomerase II) and topoisomerase IV, enzymes essential for DNA replication, transcription, and repair. By blocking these targets, the drug prevents bacterial cell division and leads to bacterial cell death, providing bactericidal activity against a wide range of Gram‑negative and Gram‑positive ocular pathogens.

Side Effects

Common Side Effects

  • Eye irritation or burning sensation.
  • Redness of the conjunctiva.
  • Transient blurred vision.
  • Increased tearing or discharge.
  • Foreign body sensation.

Serious or Rare Side Effects

  • Allergic reactions such as swelling, rash, or hives.
  • Corneal ulceration or perforation.
  • Stevens‑Johnson syndrome or toxic epidermal necrolysis.
  • Severe eye pain with vision loss.
  • Persistent or worsening infection despite therapy.

Precautions & Warnings

Before using Oftacilox, consider the following precautions:

  • Allergy assessment: verify no known hypersensitivity to fluoroquinolones or any component of the formulation.
  • Contact lens wearers: avoid use unless advised by an eye care professional, as lenses may retain the drug and increase irritation.
  • Pregnancy and lactation: use only if the potential benefit justifies the potential risk to the fetus or infant.
  • Systemic exposure: monitor for systemic fluoroquinolone effects if used for prolonged periods or on large ocular surfaces.
  • Storage: Store at room temperature below 25°C: keep in the original container, protect from light and moisture.

Avoid Interactions

Oftacilox may interact with other agents when used concurrently.

Major Interactions (Avoid)

  • Systemic fluoroquinolones: concurrent use may increase systemic exposure and risk of systemic side effects.
  • Live vaccines: avoid administration of live vaccines while using the product due to potential immunomodulation.

Moderate Interactions (Monitor Closely)

  • Topical corticosteroids: may mask signs of infection and delay healing.
  • Preservative‑containing contact lens solutions: can increase ocular irritation.
  • Other ophthalmic antibiotics: concurrent use should be guided by a clinician to prevent antagonism or additive toxicity.

Frequently Asked Questions

Oftacilox is a topical ophthalmic solution containing ciprofloxacin, a fluoroquinolone antibiotic. It is used to treat bacterial infections of the eye, such as bacterial conjunctivitis and keratitis, and may be employed as prophylaxis after ocular surgery.

Ciprofloxacin inhibits bacterial DNA gyrase and topoisomerase IV, enzymes required for DNA replication and transcription. This inhibition stops bacterial cell division, leading to rapid bactericidal activity against a broad range of ocular pathogens.

The specific dosing regimen for Oftacilox is determined by the prescribing eye care professional based on the infection type, severity, and patient factors. The prescriber will provide exact instructions on frequency and duration of use.

Ciprofloxacin is classified as a pregnancy‑category C drug. It should be used during pregnancy or lactation only if the potential benefit justifies any potential risk to the fetus or infant. The prescriber will assess the risk‑benefit profile for each individual.

To order Oftacilox, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India supplies hospitals, pharmacies, and procurement teams worldwide, and will request trade or institutional credentials before providing pricing, availability, shipping details, and any necessary import documentation.

Oftacilox (ciprofloxacin) offers broad‑spectrum coverage against both Gram‑negative and Gram‑positive ocular bacteria, often providing a wider antimicrobial spectrum than older agents such as chloramphenicol. Its fluoroquinolone class also tends to have a lower resistance rate in many regions, making it a preferred choice for many clinicians.

Oftacilox should be stored at room temperature below 25°C. Keep the bottle in its original packaging, protect it from direct light and moisture, and discard any solution that appears discolored or cloudy.

Oftacilox is applied topically to the eye as directed by the prescriber. Typically, a few drops are instilled into the affected eye(s) at the prescribed frequency, ensuring the eyelids are gently closed after administration to allow proper absorption.

Serious risks, though rare, include severe allergic reactions, corneal ulceration or perforation, and systemic fluoroquinolone effects such as tendonitis or central nervous system disturbances if significant systemic absorption occurs. Patients should seek immediate medical attention if they experience worsening eye pain, vision changes, or signs of an allergic reaction.

Individuals with a known hypersensitivity to ciprofloxacin, other fluoroquinolones, or any component of the formulation should avoid using Oftacilox. Caution is also advised for patients with a history of tendon disorders related to fluoroquinolones, and it should be used only under medical supervision in pregnant or lactating women.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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