Product image of Oftagel (Carbomer 974p) supplied by GNH India

Oftagel

Active Ingredient:
Carbomer 974p
Origin:
EU

Oftagel (Carbomer 974p)

Carbomer, the active ingredient in Oftagel, is an excipient presented as a ocular lubricant/viscosity enhancer for ophthalmic use. It provides ocular surface protection and improves tear film stability in patients with dry eye symptoms. GNH India supplies Oftagel as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

GNH India supplies Oftagel as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Santen Oy

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Indications & Clinical Uses

Oftagel is an ophthalmic viscosity enhancer that acts on the tear film layer to relieve discomfort associated with ocular surface disorders.

  • Dry eye syndrome: helps maintain moisture and reduces irritation.
  • Contact lens wear: improves lens comfort by stabilising the tear film.
  • Post‑operative ocular care: supports healing by providing a protective lubricating layer.

How It Works

  • Carbomer 974P forms a high‑molecular‑weight polymer network that increases the viscosity of ophthalmic solutions. When applied to the ocular surface, it creates a hydrated gel matrix that adheres to the cornea and conjunctiva, reducing tear evaporation and enhancing the stability of the tear film without interacting with ocular receptors.

Side Effects

Adverse reactions to Carbomer‑based ophthalmic gels are generally mild and related to local tolerance.

Common Side Effects

  • Transient blurred vision: temporary visual disturbance after instillation.
  • Mild ocular stinging: brief sensation of sting or burn.
  • Foreign‑body sensation: feeling of something in the eye.
  • Redness: mild conjunctival hyperemia.
  • Tearing: increased lacrimation.
  • Itching: mild pruritus of the ocular surface.

Serious or Rare Side Effects

  • Allergic contact dermatitis: localized skin reaction around the eye.
  • Persistent corneal epithelial defect: delayed healing of the corneal surface.
  • Severe ocular inflammation: marked conjunctival or scleral inflammation.
  • Vision loss: unexplained decrease in visual acuity.
  • Hypersensitivity reaction: systemic signs such as rash or swelling.
  • Endophthalmitis: intra‑ocular infection (extremely rare).

Precautions & Warnings

When using Carbomer ophthalmic gels, follow standard safety measures and monitor for any adverse response.

  • Patient counseling: advise that transient visual changes are common.
  • Contraindication: avoid use in patients with known hypersensitivity to carbomer or formulation excipients.
  • Contact lens wearers: remove lenses before instillation and re‑insert after the gel has settled.
  • Monitoring: assess ocular surface regularly in chronic dry‑eye patients.
  • Storage: Store at ambient temperature: keep in the original container, protect from direct sunlight and moisture.

Avoid Interactions

Carbomer ophthalmic preparations have a low potential for systemic drug interactions, but formulation components may affect the performance of other ocular products.

Major Interactions (Avoid)

  • Antimicrobial eye drops: may reduce the antimicrobial efficacy of concurrent drops.
  • Preservative‑rich solutions: can increase ocular surface irritation when used together.

Moderate Interactions (Monitor Closely)

  • Topical corticosteroids: may alter gel viscosity and drug release.
  • Other lubricants: concurrent use may cause excessive tear film thickness.
  • Punctal plugs: may increase retention time of the gel, enhancing effect.
  • Ocular anesthetics: could potentiate stinging sensation.
  • Anti‑glaucoma eye drops: monitor intra‑ocular pressure if used together.

Frequently Asked Questions

Oftagel is an ophthalmic gel that contains carbomer as a viscosity‑enhancing excipient. It is used to lubricate the ocular surface, improve tear‑film stability and relieve discomfort in conditions such as dry eye syndrome, contact lens wear and after eye surgery.

Carbomer is a high‑molecular‑weight polymer that forms a hydrated gel when mixed with water. In the eye, it creates a thin, protective layer that adheres to the cornea and conjunctiva, reducing tear evaporation and providing sustained lubrication without interacting with ocular receptors.

The prescribed dose of Oftaggel is determined by the treating clinician based on the patient’s condition and response. Typically, a small amount is instilled onto the ocular surface as directed, but exact dosing should always follow the prescriber’s instructions.

Carbomer‑based ophthalmic gels are generally considered low risk because systemic absorption is minimal. However, safety in pregnancy or lactation has not been fully established, so clinicians should weigh potential benefits against any unknown risks before prescribing.

To order Oftagel, submit an enquiry on the product page at gnhindia.com with the required quantity. GNH India supplies hospitals, pharmacies and procurement teams worldwide, and will request trade or institutional credentials before providing pricing, availability, shipping details and import documentation.

Oftagel uses carbomer to create a gel matrix that offers longer residence time on the eye compared with many aqueous drops. This can provide more sustained relief for dry‑eye symptoms, though individual response varies and some patients may prefer preservative‑free solutions or lipid‑based drops.

Store Oftagel at ambient temperature, away from direct sunlight and moisture, in its original container. Keep the cap tightly closed to maintain sterility and prevent evaporation of the gel.

Oftagel is applied topically to the ocular surface. The patient should wash hands, tilt the head back, and place a small amount of gel onto the lower conjunctival sac. Contact lenses should be removed before application and re‑inserted after the gel has settled.

Serious risks, though rare, include allergic contact dermatitis, persistent corneal epithelial defects, severe ocular inflammation, vision loss and intra‑ocular infection (endophthalmitis). Any sudden change in vision or severe eye pain should prompt immediate medical evaluation.

Individuals with a known hypersensitivity to carbomer or any component of the formulation should avoid using Oftagel. It is also contraindicated in patients with active ocular infections until the infection is resolved.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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