Product image of Oftan Chlora (Chloramphenicol) supplied by GNH India

Oftan Chlora

Active Ingredient:
Chloramphenicol
Origin:
EU

Oftan Chlora (Chloramphenicol)

Chloramphenicol, the active ingredient in Oftan Chlora, is a broad‑spectrum antibiotic presented as a topical ophthalmic solution for ocular use. It treats bacterial eye infections such as conjunctivitis and keratitis in adults and children.
GNH India supplies Oftan Chlora as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Santen Oy

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Indications & Clinical Uses

Chloramphenicol is used for bacterial eye infections, acting on the ocular surface to inhibit microbial growth.

  • Conjunctivitis: reduces bacterial load and speeds recovery of eye redness and discharge.
  • Keratitis: controls infection in the cornea, helping preserve visual acuity.
  • Blepharitis: limits bacterial colonisation of the eyelid margin, decreasing inflammation.

How It Works

  • Chloramphenicol penetrates bacterial cells and binds to the 50S ribosomal subunit, blocking peptide bond formation during protein synthesis. This inhibition halts bacterial growth, providing a bacteriostatic effect against a wide range of Gram‑positive and Gram‑negative organisms that may cause ocular infections.

Side Effects

Adverse reactions to chloramphenicol ophthalmic solution are generally mild but can occur.

Common Side Effects

  • Burning sensation: mild irritation upon instillation.
  • Redness: transient conjunctival hyperemia.
  • Tearing: increased lacrimation.
  • Foreign‑body sensation: feeling of grit in the eye.
  • Pruritus: itching of the ocular surface.
  • Blurred vision: temporary visual disturbance.

Serious or Rare Side Effects

  • Allergic contact dermatitis: swelling, erythema, or rash around the eye.
  • Stevens‑Johnson syndrome: severe mucocutaneous reaction requiring immediate medical attention.
  • Toxic optic neuropathy: progressive visual loss with prolonged use.
  • Bone marrow suppression: rare systemic effect manifesting as anemia or leukopenia.
  • Pseudomembranous conjunctivitis: formation of a membrane on the conjunctiva.
  • Corneal ulceration: worsening of corneal integrity in susceptible eyes.

Precautions & Warnings

When using chloramphenicol eye drops, consider the following safety measures.

  • Indication verification: ensure the infection is bacterial and suitable for topical therapy.
  • Duration of therapy: limit use to the prescribed period to reduce resistance risk.
  • Pediatric use: exercise caution in newborns and infants; monitor for systemic absorption.
  • Systemic absorption: be aware of rare systemic toxicity, especially with extensive ocular surface damage.
  • Contact lens wearers: remove lenses before instillation and wait before reinserting.
  • Store at ambient temperature: keep below 25°C, protect from moisture and direct sunlight.

Avoid Interactions

Chloramphenicol ophthalmic solution may interact with other ocular medications or systemic agents.

Major Interactions (Avoid)

  • Systemic aminoglycosides: concurrent use can increase risk of ototoxicity.
  • Systemic anticoagulants: may potentiate bleeding tendencies if significant systemic absorption occurs.

Moderate Interactions (Monitor Closely)

  • Other topical antibiotics: may cause additive irritation or antagonistic effects.
  • Non‑steroidal anti‑inflammatory eye drops: monitor for increased ocular surface irritation.
  • Corticosteroid eye drops: assess for delayed wound healing when used together.

Frequently Asked Questions

Oftan Chlora is a chloramphenicol‑based ophthalmic solution indicated for the topical treatment of bacterial eye infections such as conjunctivitis, keratitis and blepharitis. It works by reducing the bacterial load on the ocular surface, helping to relieve symptoms and prevent complications.

Chloramphenicol inhibits bacterial protein synthesis by binding to the 50S ribosomal subunit, which stops peptide chain formation. This bacteriostatic action limits the growth of susceptible Gram‑positive and Gram‑negative organisms that cause ocular infections.

The dosing regimen for Oftan Chlora is determined by the prescribing clinician based on the type and severity of the infection, patient age and response to therapy. The prescriber will specify the number of drops and frequency appropriate for each case.

Chloramphenicol is classified as a pregnancy‑category C drug; it should be used only if the potential benefit justifies the potential risk to the fetus. Limited systemic absorption from eye drops makes exposure low, but caution is advised. Use while breastfeeding is generally considered acceptable if needed, but consult a healthcare professional.

To place an order, submit an enquiry on the product page at gnhindia.com, providing the required quantity. GNH India supplies hospitals, pharmacies and procurement teams worldwide, and will request trade or institutional credentials before responding with pricing, availability, shipping details and any necessary import documentation.

Oftan Chlora (chloramphenicol) offers broad‑spectrum coverage against many ocular pathogens and is available as a convenient eye‑drop formulation. Compared with fluoroquinolone eye drops, chloramphenicol has a lower risk of developing resistance but may carry rare systemic toxicity, so choice depends on infection type, local resistance patterns and patient factors.

Store the ophthalmic solution at ambient temperature, preferably below 25 °C, in its original container protected from moisture and direct sunlight. Keep the bottle tightly closed and discard any remaining product after the labeled period after opening.

The solution is applied topically to the affected eye(s) as directed by the prescriber, typically by instilling one to two drops into the conjunctival sac. Patients should wash their hands before use, avoid touching the tip to the eye or any surface, and follow any specific instructions regarding contact lens use.

Serious adverse reactions, although rare, include allergic contact dermatitis, Stevens‑Johnson syndrome, toxic optic neuropathy and bone‑marrow suppression. Any signs of severe eye irritation, systemic symptoms or visual changes should prompt immediate medical evaluation.

Patients with a known hypersensitivity to chloramphenicol or any component of the formulation should avoid using the product. Caution is also advised for newborns, infants and individuals with extensive corneal damage, as systemic absorption may be higher in these groups.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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