Oftan Dexa (Dexamethasone Sodium Phosphate)

Oftan Dexa is a corticosteroid that acts on inflammatory and immune pathways across several clinical areas.

• Allergic reactions: Provides rapid relief of severe hypersensitivity symptoms.
• Cerebral edema: Decreases swelling associated with brain tumors or trauma.
• Acute asthma exacerbations: Improves airway patency by reducing airway inflammation.
• Post‑operative inflammation: Limits tissue swelling and pain after surgery.
• Autoimmune disorders: Suppresses abnormal immune activity in conditions such as systemic lupus erythematosus.

• Dexamethasone sodium phosphate penetrates cells and binds to intracellular glucocorticoid receptors, forming a complex that translocates to the nucleus. This complex alters gene transcription, suppressing pro‑inflammatory cytokines, inhibiting phospholipase A2 activity, and reducing the synthesis of prostaglandins and leukotrienes, thereby providing potent anti‑inflammatory and immunosuppressive effects.

Adverse reactions may range from mild to severe and should be monitored during therapy.

Common Side Effects

• Elevated blood glucose levels
• Mood changes or insomnia
• Gastrointestinal discomfort
• Facial flushing or skin thinning
• Local injection site pain
• Mild electrolyte disturbances

Serious or Rare Side Effects

• Severe infection risk
• Peptic ulcer perforation
• Acute adrenal insufficiency
• Osteonecrosis of the jaw
• Vision changes or cataract formation
• Anaphylactic reaction

When using Oftan Dexa, clinicians should consider several safety measures to minimise risk.

• Assess baseline blood glucose: Monitor patients with diabetes closely.
• Evaluate infection risk: Avoid use in uncontrolled systemic infections.
• Review psychiatric history: Corticosteroids may exacerbate mood disorders.
• Monitor electrolytes: Particularly potassium and sodium levels.
• Consider bone health: Use calcium and vitamin D supplementation if long‑term therapy is anticipated.
• Store at ambient temperature: Keep in original container, protect from light and moisture.

Oftan Dexa can interact with a range of medicines, altering efficacy or safety.

Major Interactions (Avoid)

• CYP1A2 substrates :   ---  ---  --- --- --- --- --- …  ...  ...  ...  ... ---  ... ... ---  … … 

Moderate