Product image of Oftan Dexa-Chlora (Chloramphenicol, Dexamethasone) supplied by GNH India

Oftan Dexa-Chlora

Active Ingredient:
Chloramphenicol, Dexamethasone
Origin:
EU

Oftan Dexa-Chlora (Chloramphenicol, Dexamethasone)

Chloramphenicol and dexamethasone, the active ingredients in Oftan Dexa-Chlora, are an antibiotic and a corticosteroid presented as an ophthalmic preparation for ocular use. They treat bacterial conjunctivitis, ocular inflammation and are used for post‑operative prophylaxis in patients who need topical therapy.

GNH India supplies Oftan Dexa-Chlora as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Santen Oy

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Indications & Clinical Uses

Oftan Dexa‑Chlora combines an antibacterial and anti‑inflammatory agent to address ocular infections and inflammation.

  • Bacterial conjunctivitis: reduces bacterial load and resolves redness and discharge.
  • Ocular inflammation: suppresses inflammatory cytokines, decreasing swelling and pain.
  • Post‑operative prophylaxis: prevents infection and inflammation after eye surgery.

How It Works

  • Chloramphenicol binds to the 50S ribosomal subunit of susceptible bacteria, inhibiting protein synthesis and halting bacterial growth. Dexamethasone activates intracellular glucocorticoid receptors, leading to transcriptional repression of pro‑inflammatory genes and reducing cytokine production, edema and cellular infiltration in ocular tissues.

Side Effects

Oftan Dexa‑Chlora may cause local ocular reactions and, rarely, systemic adverse events.

Common Side Effects

  • Stinging or burning sensation upon instillation.
  • Transient blurred vision.
  • Mild ocular irritation or redness.
  • Increased intra‑ocular pressure with prolonged use.

Serious or Rare Side Effects

  • Corneal ulceration or secondary infection.
  • Cataract formation with long‑term corticosteroid exposure.
  • Systemic bone‑marrow suppression from chloramphenicol absorption.
  • Glaucoma development due to sustained pressure rise.
  • Allergic hypersensitivity reactions, including angioedema.

Precautions & Warnings

Before using Oftan Dexa‑Chlora, consider the following safety measures.

  • Pregnancy: consult a physician; limited safety data are available.
  • Breastfeeding: weigh potential risks to the infant before use.
  • Children: use only under medical supervision and for approved indications.
  • Contact lens wearers: avoid use or remove lenses before instillation.
  • Prolonged therapy: monitor intra‑ocular pressure and signs of secondary infection.
  • Store at room temperature: keep in original container, protect from light and moisture.

Avoid Interactions

Oftan Dexa‑Chlora can interact with systemic and ocular medications.

Major Interactions (Avoid)

  • Systemic chloramphenicol: additive risk of bone‑marrow suppression.
  • Systemic corticosteroids: increased systemic glucocorticoid effects.
  • Live vaccines: potential immunosuppression may reduce vaccine efficacy.

Moderate Interactions (Monitor Closely)

  • Topical non‑steroidal anti‑inflammatory eye drops: may increase ocular irritation.
  • Antifungal eye drops: possible reduced antifungal activity.
  • Contact lens solutions: may affect drug stability or cause precipitation.

Frequently Asked Questions

Oftan Dexa‑Chlora is a prescription ophthalmic preparation that combines chloramphenicol and dexamethasone to treat bacterial conjunctivitis, reduce ocular inflammation, and provide prophylaxis after eye surgery. It is applied directly to the eye to target infection and inflammation locally.

Chloramphenicol inhibits bacterial protein synthesis by binding to the 50S ribosomal subunit, stopping bacterial growth. Dexamethasone activates glucocorticoid receptors, suppressing inflammatory cytokine production and reducing swelling, pain, and cellular infiltration in ocular tissues.

The dosing regimen for Oftan Dexa‑Chlora is determined by the prescribing clinician based on the specific condition, severity, and patient factors. The prescriber will provide instructions on the number of drops, frequency, and duration of therapy.

Safety data for chloramphenicol/dexamethasone in pregnancy and lactation are limited. Healthcare providers should evaluate the potential benefits against possible risks before prescribing to pregnant or nursing women. Consultation with a physician is essential.

To order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, confirming trade or institutional credentials before providing pricing, availability, shipping details, and necessary import documentation.

Compared with single‑agent eye drops, Oftan Dexa‑Chlora offers both antibacterial and anti‑inflammatory actions in one formulation, reducing the need for multiple products. It is particularly useful when infection and inflammation coexist, whereas alternatives may address only one aspect.

Store the product at room temperature, away from direct sunlight and moisture. Keep it in the original container with the cap tightly closed. Do not freeze or expose to extreme temperatures, and discard any solution that appears discolored or contaminated.

The medication is applied as eye drops. The patient should wash hands, tilt the head back, pull down the lower eyelid to form a pocket, and instill the prescribed number of drops. Close the eye gently for a few seconds and avoid blinking excessively.

Serious risks include corneal ulceration, secondary ocular infection, cataract formation, increased intra‑ocular pressure leading to glaucoma, and rare systemic bone‑marrow suppression from chloramphenicol absorption. Prompt medical attention is required if any severe symptoms develop.

Patients with known hypersensitivity to chloramphenicol, dexamethasone, or any component of the formulation should avoid use. It is also contraindicated in viral eye infections such as herpes simplex keratitis, unless specifically directed by a specialist.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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