Product image of Oftan (Timolol Maleate) supplied by GNH India

Oftan

Active Ingredient:
Timolol Maleate
Origin:
EU

Oftan (Timolol Maleate)

Timolol Maleate, the active ingredient in Oftan, is a beta‑adrenergic blocker presented as an ophthalmic solution for topical ocular use. It lowers intra‑ocular pressure in patients with glaucoma or ocular hypertension.

GNH India supplies Oftan as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Santen Oy

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Indications & Clinical Uses

Timolol Maleate is a non‑selective beta‑blocker used to manage ocular pressure in glaucoma and related conditions.

  • Open‑angle glaucoma: reduces intra‑ocular pressure to slow disease progression
  • Ocular hypertension: lowers pressure to prevent conversion to glaucoma
  • Secondary glaucoma: helps control pressure when caused by other eye conditions

How It Works

  • Timolol maleate competitively blocks β1 and β2 adrenergic receptors in the ciliary body, decreasing aqueous humor production. The resulting reduction in aqueous humor formation lowers intra‑ocular pressure, helping to protect the optic nerve from glaucomatous damage.

Side Effects

Timolol ophthalmic solution may cause a range of ocular and systemic reactions.

Common Side Effects

  • Burning or stinging sensation in the eye
  • Transient blurred vision
  • Dry eye or reduced tear production
  • Conjunctival hyperemia (redness)
  • Temporary foreign‑body sensation
  • Mild headache

Serious or Rare Side Effects

  • Severe bradycardia or heart block
  • Systemic hypotension
  • Bronchospasm or worsening asthma
  • Allergic reactions (rash, swelling, anaphylaxis)
  • Marked hypoglycaemia in diabetic patients
  • Depression or mood changes

Precautions & Warnings

Timolol ophthalmic solution requires careful assessment before use.

  • Cardiovascular assessment: avoid in patients with uncontrolled bradycardia or heart block
  • Respiratory screening: use with caution in asthma or COPD
  • Blood‑glucose monitoring: may mask hypoglycaemia symptoms in diabetics
  • Concomitant non‑selective beta‑blockers: risk of additive systemic effects
  • Pregnancy and lactation: prescribe only if benefit outweighs potential risk
  • Store at ambient temperature: keep below 25 °C, protect from moisture and light

Avoid Interactions

Timolol may interact with several systemic and ocular agents.

Major Interactions (Avoid)

  • Other non‑selective beta‑blockers: additive systemic beta‑blockade
  • Calcium channel blockers (verapamil, diltiazem): may enhance bradycardia
  • Antidiabetic drugs (insulin, sulfonylureas): may mask hypoglycaemia

Moderate Interactions (Monitor Closely)

  • Topical anesthetics: may increase ocular irritation
  • Other ocular hypotensive agents (prostaglandin analogues): monitor intra‑ocular pressure response
  • Systemic antihypertensives: watch for excessive blood‑pressure reduction

Frequently Asked Questions

Oftan contains timolol maleate, a beta‑blocker formulated as an ophthalmic solution. It is used to lower intra‑ocular pressure in patients with open‑angle glaucoma, ocular hypertension, and certain forms of secondary glaucoma, helping to prevent optic‑nerve damage.

Timolol maleate blocks β1 and β2 adrenergic receptors in the eye’s ciliary body, which reduces the production of aqueous humor. The decrease in fluid formation lowers intra‑ocular pressure, a key factor in managing glaucoma and related conditions.

The prescribed dose of Oftan is determined by the treating eye‑care professional based on the patient’s condition, response, and tolerance. The prescriber will specify the number of drops and frequency, typically one drop per eye once or twice daily.

Timolol should be used in pregnancy or while breastfeeding only if the potential benefit justifies the potential risk to the fetus or infant. Healthcare providers evaluate each case individually and may consider alternative therapies when appropriate.

To place an order, submit an enquiry on the product page at gnhindia.com, indicating the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Oftan (timolol) is a non‑selective beta‑blocker, offering a well‑established efficacy profile for reducing intra‑ocular pressure. Compared with prostaglandin analogues, timolol may have fewer ocular surface changes but can produce systemic beta‑blocker effects, so patient comorbidities guide the choice of therapy.

Oftan should be stored at ambient temperature, preferably below 25 °C. Keep the bottle in its original packaging, protect it from moisture and direct sunlight, and ensure the cap is tightly closed to maintain sterility.

Oftan is applied topically to the eye. The patient should wash hands, tilt the head back, pull down the lower eyelid to create a small pocket, and place the prescribed number of drops into the conjunctival sac. Close the eye gently and avoid blinking excessively for a few seconds.

Serious risks include systemic bradycardia, hypotension, bronchospasm in patients with asthma or COPD, severe allergic reactions, and masking of hypoglycaemic symptoms in diabetic patients. Patients should be instructed to seek immediate medical attention if they experience chest pain, severe shortness of breath, or signs of an allergic reaction.

Oftan is contraindicated in patients with known hypersensitivity to timolol or any component of the formulation, those with severe sinus bradycardia, second‑ or third‑degree heart block without a pacemaker, and individuals with uncontrolled asthma or severe chronic obstructive pulmonary disease.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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