Product image of Oftan (Timolol Maleate) supplied by GNH India

Oftan

Active Ingredient:
Timolol Maleate
Origin:
EU

Oftan (Timolol Maleate)

Timolol Maleate, the active ingredient in Oftan, is a beta‑blocker presented as a 0.5% ophthalmic solution for topical ocular use. It lowers intra‑ocular pressure and is used to manage glaucoma and ocular hypertension in adults.
GNH India supplies Oftan as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Santen Oy

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Indications & Clinical Uses

Timolol maleate acts on ocular fluid dynamics to reduce intra‑ocular pressure, making it useful in several eye‑pressure disorders.

  • Primary open‑angle glaucoma: lowers intra‑ocular pressure to slow optic nerve damage.
  • Ocular hypertension: reduces pressure to prevent progression to glaucoma.
  • Secondary glaucoma (e.g., pseudoexfoliative): helps control pressure when other mechanisms are involved.

How It Works

  • Timolol maleate is a non‑selective beta‑adrenergic antagonist that blocks β1 and β2 receptors in the ciliary body, decreasing aqueous humor production and thereby reducing intra‑ocular pressure.

Side Effects

Timolol maleate may cause ocular and systemic adverse reactions.

Common Side Effects

  • Burning or stinging sensation upon instillation.
  • Blurred vision shortly after use.
  • Dry eye or foreign‑body sensation.
  • Mild conjunctival hyperemia.
  • Temporary reduction in pupil size.
  • Mild headache.

Serious or Rare Side Effects

  • Bradycardia or heart block.
  • Bronchospasm, especially in asthmatic patients.
  • Severe hypotension.
  • Allergic contact dermatitis of the eyelid.
  • Visual disturbances such as decreased visual acuity.
  • Systemic hypoglycaemia in diabetic patients.

Precautions & Warnings

Timolol maleate requires careful consideration of patient‑specific factors before use.

  • Cardiac monitoring: assess heart rate and rhythm in patients with cardiac disease.
  • Respiratory caution: avoid in patients with asthma or chronic obstructive pulmonary disease.
  • Diabetes awareness: monitor blood glucose as systemic absorption may mask hypoglycaemia.
  • Pregnancy and lactation: use only if potential benefit justifies potential risk.
  • Drug discontinuation: taper under medical supervision to avoid rebound intra‑ocular pressure rise.
  • Store at ambient temperature: keep below 25 °C, in the original container, protected from moisture and direct sunlight.

Avoid Interactions

Timolol maleate can interact with systemic and ocular agents, influencing its safety profile.

Major Interactions (Avoid)

  • Other non‑selective beta‑blockers: additive bradycardia and hypotension.
  • Calcium channel blockers (e.g., verapamil): increased risk of heart block.
  • Antihypertensive agents: may cause excessive blood pressure reduction.

Moderate Interactions (Monitor Closely)

  • Inhaled beta‑agonists (e.g., albuterol): may reduce bronchodilator efficacy.
  • Antidiabetic drugs: timolol may mask hypoglycaemic symptoms.
  • NSAIDs: potential for reduced renal perfusion when combined with systemic beta‑blockade.

Frequently Asked Questions

Oftan contains timolol maleate, a beta‑blocker eye drop used to lower intra‑ocular pressure in conditions such as primary open‑angle glaucoma, ocular hypertension, and certain forms of secondary glaucoma. By reducing pressure, it helps protect the optic nerve from damage.

Timolol maleate blocks β‑adrenergic receptors in the ciliary body of the eye, which decreases the production of aqueous humor. The reduced fluid formation leads to lower intra‑ocular pressure, helping to prevent progression of glaucomatous damage.

The dosing regimen for Oftan is determined by the prescribing clinician based on the patient’s condition, response, and tolerance. Typically, one or two drops are instilled in the affected eye(s) once or twice daily, but the exact schedule must be individualized.

Timolol should be used during pregnancy or lactation only if the potential benefit outweighs the risk to the fetus or infant. Systemic absorption is low, but caution is advised, and the prescriber should evaluate the safety profile for each case.

To order Oftan, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details, and any necessary import documentation.

Oftan (timolol) is a non‑selective beta‑blocker, offering a well‑established efficacy profile for lowering intra‑ocular pressure. Compared with prostaglandin analogues, timolol may have a quicker onset but can cause systemic beta‑blockade effects, whereas prostaglandins often have fewer systemic concerns but may cause eyelash growth or iris pigmentation.

Store Oftan at ambient temperature, preferably below 25 °C. Keep the bottle in its original packaging, protect it from moisture and direct sunlight, and ensure the cap is tightly closed to maintain sterility.

Oftan is administered as an ophthalmic solution. The patient should wash hands, tilt the head back, pull down the lower eyelid to form a pocket, and place the prescribed number of drops into the conjunctival sac without touching the tip of the bottle to the eye or surrounding tissues.

Serious risks include significant bradycardia, heart block, severe hypotension, bronchospasm in patients with reactive airway disease, and systemic hypoglycaemia unawareness in diabetic patients. Any signs of these reactions require immediate medical attention.

Oftan is contraindicated in patients with known hypersensitivity to timolol or any component of the formulation, severe sinus bradycardia, second‑ or third‑degree heart block, uncontrolled asthma, or chronic obstructive pulmonary disease. It should also be used with caution in patients with diabetes, cardiovascular disease, or renal impairment.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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