Product image of Oftaquix (Levofloxacin Hemihydrate) supplied by GNH India

Oftaquix

Active Ingredient:
Levofloxacin Hemihydrate
Origin:
EU

Oftaquix (Levofloxacin Hemihydrate)

Levofloxacin Hemihydrate, the active ingredient in Oftquen, is a fluoroquinolone antibiotic presented as a tablet for oral use. It treats a variety of bacterial infections in adults and children when prescribed by a healthcare professional.

GNH India supplies Oftquen as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Santen Oy

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Indications & Clinical Uses

Oftquen is a broad‑spectrum antibiotic that targets bacterial pathogens in several organ systems.

  • Community‑acquired pneumonia: helps reduce bacterial load and improve respiratory symptoms.
  • Acute bacterial sinusitis: shortens the duration of sinus inflammation and discharge.
  • Uncomplicated urinary tract infections: eradicates the causative uropathogens and relieves dysuria.

How It Works

  • Levofloxacin inhibits bacterial DNA gyrase and topoisomerase IV, enzymes essential for DNA replication, transcription and repair. By blocking these enzymes, the drug prevents bacterial cells from proliferating and leads to cell death, providing a bactericidal effect against susceptible Gram‑negative and Gram‑positive organisms.

Side Effects

Levofloxacin may cause a range of adverse reactions, most of which are mild and reversible.

Common Side Effects

  • Nausea or vomiting
  • Diarrhea
  • Headache
  • Dizziness
  • Photosensitivity
  • Abdominal pain

Serious or Rare Side Effects

  • Tendon rupture or inflammation
  • Peripheral neuropathy
  • QT‑interval prolongation
  • Severe allergic reactions (anaphylaxis, angioedema)
  • Clostridioides difficile‑associated colitis
  • Hepatotoxicity

Precautions & Warnings

Levofloxacin should be used with caution in specific clinical situations.

  • Renal impairment: adjust dose based on renal function.
  • History of tendon disorders: avoid use or monitor closely.
  • Cardiac arrhythmias: assess QT interval before initiating therapy.
  • Pregnancy and lactation: only use if clearly needed, after risk‑benefit assessment.
  • Concomitant use with antacids or supplements containing magnesium or aluminum: separate administration times.
  • Store at below 25°C: keep in the original packaging, protect from moisture and light.

Avoid Interactions

Levofloxacin can interact with several medicines, altering its efficacy or safety profile.

Major Interactions (Avoid)

  • Antacids containing magnesium or aluminum: reduce levofloxacin absorption.
  • Non‑steroidal anti‑inflammatory drugs (NSAIDs): increase risk of central nervous system stimulation.
  • Warfarin: may enhance anticoagulant effect and raise bleeding risk.

Moderate Interactions (Monitor Closely)

  • Theophylline: may increase serum theophylline concentrations.
  • Cyclosporine: potential for increased nephrotoxicity.
  • Corticosteroids: heightened risk of tendon injury.

Frequently Asked Questions

Oftquen contains levofloxacin, a fluoroquinolone antibiotic that is prescribed to treat a range of bacterial infections such as community‑acquired pneumonia, acute bacterial sinusitis and uncomplicated urinary tract infections in patients for whom other antibiotics may be unsuitable.

Levofloxacin blocks bacterial DNA gyrase and topoisomerase IV, enzymes that are essential for DNA replication and repair. This inhibition stops bacterial cells from multiplying, leading to a bactericulticidal effect against susceptible organisms.

The dose of levofloxacin is individualized by the prescribing clinician based on the infection type, severity, patient age, kidney function and other clinical factors. The prescriber determines the appropriate strength, frequency and duration of therapy.

Levofloxacin is classified as pregnancy‑category C and should only be used when the potential benefit outweighs the risk to the fetus. It is excreted in breast milk, so breastfeeding mothers should consult their healthcare provider before using the medication.

To request Oftquen, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Compared with older fluoroquinolones, levofloxacin offers once‑daily dosing and a broad spectrum that includes many Gram‑negative and Gram‑positive bacteria. It is often preferred over agents such as ciprofloxacin for respiratory infections because of its enhanced activity against Streptococcus pneumoniae.

Store the tablets at temperatures below 25 °C in the original container, protecting them from moisture and direct light. Do not use the product if the packaging is damaged or if the tablets appear discoloured.

Oftquen is supplied as oral tablets that are swallowed whole with a glass of water. It can be taken with or without food, but patients should avoid taking it simultaneously with antacids or supplements containing magnesium, aluminum or calcium.

Serious adverse events include tendon rupture or inflammation, peripheral neuropathy, QT‑interval prolongation, severe allergic reactions and Clostridioides difficile‑associated colitis. Patients should seek immediate medical attention if they experience sudden joint pain, palpitations, severe rash or persistent diarrhea.

Levofloxacin is contraindicated in patients with a known hypersensitivity to fluoroquinolones, those with a history of tendon disorders related to fluoroquinolone use, and individuals taking medications that may cause dangerous QT prolongation without careful monitoring.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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