Product image of Oftaquix (Levofloxacin Hemihydrate) supplied by GNH India

Oftaquix

Active Ingredient:
Levofloxacin Hemihydrate
Origin:
EU

Oftaquix (Levofloxacin Hemihydrate)

Levofloxacin, the active ingredient in Oftaquix, is a fluoroquinolone presented as an ophthalmic solution for ocular use. It treats bacterial eye infections such as conjunctivitis and keratitis in both adult and pediatric patients.

GNH India supplies Oftaquix as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide. The company adheres to EU GMP standards and provides regulatory documentation for importers. Its global logistics network ensures timely delivery across multiple continents while maintaining product integrity through validated temperature‑controlled packaging.

Manufacturer / TM Owner

Santen Oy

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Indications & Clinical Uses

  • Oftaquix (levofloxacin) is used to treat bacterial infections of the eye, targeting common ocular pathogens.
  • Bacterial conjunctivitis: reduces bacterial load and accelerates symptom resolution.
  • Bacterial keratitis: eradicates causative organisms and promotes corneal healing.
  • Corneal ulcer: provides broad‑spectrum coverage to prevent progression and facilitate epithelial regeneration.

How It Works

  • Levofloxacin inhibits bacterial DNA gyrase (topoisomerase II) and topoisomerase IV, enzymes essential for DNA replication, transcription and repair. By binding to the quinolone‑binding site, it prevents DNA supercoiling and strand separation, leading to bacterial cell death. This high affinity for both Gram‑negative and Gram‑positive ocular pathogens underlies its broad‑spectrum antibacterial activity when applied topically to the eye.

Side Effects

Oftaquix may cause ocular and systemic adverse reactions, most of which are mild and transient.

Common Side Effects

  • Transient burning or stinging sensation upon instillation.
  • Mild conjunctival hyperemia (redness).
  • Temporary blurred vision or foreign‑body feeling.
  • Mild itching or tearing.

Serious or Rare Side Effects

  • Corneal epithelial toxicity or ulceration.
  • Severe allergic reactions including angioedema, Stevens‑Johnson syndrome or toxic epidermal necrolysis.
  • Systemic tendon rupture or tendonitis, especially in patients on corticosteroids.

Precautions & Warnings

Before prescribing Oftaquix, consider the following precautions to ensure safe use.

  • Hypersensitivity: discontinue if patient shows signs of allergic reaction.
  • Corneal disease: avoid in patients with active corneal epithelial defects unless benefits outweigh risks.
  • Pregnancy and lactation: use only if clearly needed, as safety data are limited.
  • Concurrent systemic fluoroquinolone therapy: monitor for additive toxicity.
  • Drug interactions: be cautious with NSAIDs or corticosteroids that may increase risk of tendon injury.
  • Store at ambient temperature: keep below 25 °C, protect from moisture and light in original container.

Avoid Interactions

Levofloxacin can interact with other medicines, affecting its efficacy or safety.

Major Interactions (Avoid)

  • Antacids, iron or zinc supplements: chelate levofloxacin and markedly reduce ocular absorption.
  • Warfarin: may potentiate anticoagulant effect, increasing bleeding risk.
  • Systemic corticosteroids: increase risk of tendon rupture.

Moderate Interactions (Monitor Closely)

  • Non‑steroidal anti‑inflammatory drugs (NSAIDs): may enhance risk of corneal toxicity.
  • Other fluoroquinolones: additive toxicity, avoid concurrent use.
  • Diabetes medications: monitor blood glucose as fluoroquinolones can affect glycemic control.

Frequently Asked Questions

Oftaquix contains levofloxacin, a fluoroquinolone antibacterial, and is indicated for the treatment of bacterial eye infections such as conjunctivitis, keratitis and corneal ulcers. It is applied topically to the eye to eradicate susceptible bacteria and promote healing.

Levofloxacin inhibits bacterial DNA gyrase and topoisomerase IV, enzymes required for DNA replication and transcription. By blocking these targets, the drug prevents bacterial cell division and leads to rapid bacterial death, providing broad‑spectrum coverage against common ocular pathogens.

The dosing regimen for Oftaquix is determined by the prescribing clinician based on the specific infection, severity and patient factors. The product is supplied as an ophthalmic solution to be instilled in the affected eye(s) as directed by a qualified healthcare professional.

Safety data for levofloxacin ophthalmic use in pregnancy and lactation are limited. The product should be used only if clearly needed and after a risk‑benefit assessment by the prescriber. Women who are pregnant, planning pregnancy or breastfeeding should discuss alternatives with their doctor.

To request Oftaquix, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India supplies hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any required import documentation.

Oftaquix (levofloxacin) offers a broad‑spectrum fluoroquinolone option with strong activity against both Gram‑negative and Gram‑positive ocular bacteria. Compared with older agents such as ciprofloxacin, levofloxacin often provides higher potency, better tissue penetration and a lower risk of resistance development, making it a preferred choice for many clinicians.

Oftaquix should be stored at ambient temperature, preferably below 25 °C. Keep the vial in its original packaging, protect it from moisture and direct light, and ensure the cap is tightly closed when not in use to maintain sterility and potency.

The product is supplied as a sterile ophthalmic solution. The prescribed number of drops is instilled into the affected eye(s) using the provided dropper, typically at intervals recommended by the prescriber. Patients should avoid touching the tip of the bottle to the eye or any surface to preserve sterility.

Serious risks, although rare, include corneal epithelial toxicity or ulceration, severe allergic reactions such as Stevens‑Johnson syndrome, and systemic tendon rupture, especially in patients receiving systemic corticosteroids. Any signs of severe eye pain, vision loss, rash or swelling should prompt immediate medical attention.

Oftaquix is contraindicated in individuals with known hypersensitivity to levofloxacin, other fluoroquinolones, or any component of the formulation. Caution is advised for patients with active corneal epithelial defects, those on systemic corticosteroids, and pregnant or breastfeeding women unless the benefit outweighs the risk.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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