Product image of Oftaquix (Levofloxacin Hemihydrate) supplied by GNH India

Oftaquix

Active Ingredient:
Levofloxacin Hemihydrate
Origin:
EU

Oftaquix (Levofloxacin Hemihydrate)

Levofloxacin Hemihydrate, the active ingredient in Oftaquix, is a fluoroquinolone antibiotic presented as a tablet for oral use. It treats a variety of bacterial infections in adults and children when appropriate.

GNH India supplies Oftaquix as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Santen Oy

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Indications & Clinical Uses

Levofloxacin is a broad‑spectrum antibacterial agent used for infections affecting several organ systems.

  • Community‑acquired bacterial pneumonia: helps achieve clinical cure and bacterial eradication.
  • Acute bacterial sinusitis: reduces symptoms and clears the infecting pathogen.
  • Uncomplicated urinary tract infection: provides bacterial eradication and symptom relief.
  • Skin and soft‑tissue infections: assists in resolving infection and preventing spread.
  • Chronic bronchitis exacerbations: aids in bacterial clearance and improves airflow.
  • Gonorrhoea (single‑dose therapy): offers microbiological cure.

How It Works

  • Levofloxacin inhibits bacterial DNA gyrase and topoisomerase IV, enzymes essential for DNA replication, transcription and repair. By stabilising the DNA‑enzyme complex, it prevents strand re‑ligation, leading to lethal DNA breaks and bacterial cell death. This bactericidal action is effective against a wide range of Gram‑positive and Gram‑negative organisms.

Side Effects

Levofloxacin may cause a range of adverse reactions, most of which are mild and self‑limiting.

Common Side Effects

  • Nausea: mild stomach upset often reported.
  • Diarrhea: loose stools that usually resolve without treatment.
  • Headache: transient cranial discomfort.
  • Dizziness: occasional light‑headedness.
  • Photosensitivity: increased skin sensitivity to sunlight.
  • Abdominal pain: cramping or discomfort in the stomach area.

Serious or Rare Side Effects

  • Tendon rupture: sudden tendon pain or rupture, especially in the Achilles.
  • QT prolongation: irregular heart rhythm detectable on ECG.
  • Severe allergic reaction: rash, swelling, or difficulty breathing.
  • Clostridioides difficile infection: persistent watery diarrhea.
  • Peripheral neuropathy: tingling or numbness in extremities.
  • Hepatotoxicity: elevated liver enzymes or jaundice.

Precautions & Warnings

Levofloxacin should be used with caution in patients with specific risk factors and medical histories.

  • Renal impairment: dose adjustment may be required based on kidney function.
  • History of tendon disorders: avoid use if previous tendon inflammation or rupture occurred.
  • Cardiac arrhythmias: monitor QT interval in patients with known prolongation.
  • Seizure disorders: use cautiously as it may lower seizure threshold.
  • Pregnancy and lactation: only prescribe if benefits outweigh potential risks.
  • Store at below 25°C: keep in the original packaging, protect from moisture and direct sunlight.

Avoid Interactions

Levofloxacin can interact with several medicines, altering its efficacy or safety profile.

Major Interactions (Avoid)

  • Antacids containing aluminum or magnesium: reduce levofloxacin absorption.
  • Warfarin: may increase anticoagulant effect and bleeding risk.
  • NSAIDs (e.g., ibuprofen): heighten risk of central nervous system stimulation.

Moderate Interactions (Monitor Closely)

  • Theophylline: may increase serum theophylline concentrations.
  • Cyclosporine: potential for increased nephrotoxicity.
  • Oral hypoglycemics: may enhance glucose‑lowering effect.

Frequently Asked Questions

Oftaquix contains levofloxacin, a fluoroquinolone antibiotic that is indicated for a range of bacterial infections such as community‑acquired pneumonia, acute bacterial sinusitis, uncomplicated urinary tract infections, skin and soft‑tissue infections, chronic bronchitis exacerbations and certain sexually transmitted infections like gonorrhoea.

Levofloxacin blocks bacterial DNA gyrase and topoisomerase IV, enzymes that unwind and reseal DNA during replication. Inhibiting these enzymes creates DNA breaks that cannot be repaired, leading to bacterial cell death and eradication of the infection.

The dosage of Oftaquix is determined by the prescribing clinician based on the type and severity of the infection, patient age, weight, kidney function and other clinical factors. The prescriber sets the appropriate strength, frequency and duration.

Levofloxacin is classified as pregnancy category C in many regions, meaning it should only be used when the potential benefit justifies any potential risk to the fetus. It is excreted in breast milk, so breastfeeding mothers should discuss risks and alternatives with their healthcare provider.

To order Oftaquix, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Levofloxacin offers once‑daily dosing and a broad spectrum that includes many Gram‑positive and Gram‑negative organisms, similar to other fluoroquinolones like ciprofloxacin. Compared with some agents, levofloxacin has a slightly better safety profile for tendon‑related events but shares class‑wide warnings such as QT prolongation and photosensitivity.

Oftaquix tablets should be stored at temperatures below 25 °C, in the original container to protect from moisture and direct sunlight. Keeping the product in a dry, cool environment maintains its stability and potency throughout its shelf life.

Oftaquix is supplied as oral tablets that are swallowed whole with a full glass of water. It can be taken with or without food, but patients should avoid concurrent intake of antacids containing aluminum or magnesium, which may interfere with absorption.

Serious risks include tendon rupture or inflammation, especially in the Achilles tendon, QT‑interval prolongation that can lead to arrhythmias, severe allergic reactions such as anaphylaxis, Clostridioides difficile‑associated colitis, and peripheral neuropathy. Patients should seek immediate medical attention if they experience any of these symptoms.

Oftaquix should be avoided in individuals with a known hypersensitivity to levofloxacin or other fluoroquinolones, those with a history of tendon disorders related to fluoroquinolone use, patients with uncontrolled epilepsy, and anyone with a prolonged QT interval unless the benefit outweighs the risk.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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