Product image of Ogast (Lansoprazole) supplied by GNH India

Ogast

Active Ingredient:
Lansoprazole
Origin:
EU

Ogast (Lansoprazole)

Lansoprazole, the active ingredient in Ogast, is a proton pump inhibitor presented as a 20 mg tablet for oral use. It reduces gastric acid secretion and is used to treat conditions such as gastro‑oesophageal reflux disease, peptic ulcer disease and Helicobacter pylori infection in adults.

GNH India supplies Ogast as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Takeda France Sas

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Indications & Clinical Uses

Lansoprazole acts on the gastric proton pump to decrease acid production, making it useful for several acid‑related disorders.

  • Gastro‑oesophageal reflux disease (GERD): provides symptomatic relief and promotes healing of esophageal erosion.
  • Erosive esophagitis: accelerates mucosal healing and reduces recurrence.
  • Peptic ulcer disease: supports ulcer healing and prevents recurrence.
  • Helicobacter pylori eradication regimens: enhances the effectiveness of antibiotic combinations.

How It Works

  • Lansoprazole selectively and irreversibly inhibits the H+/K+‑ATPase enzyme (the gastric proton pump) located on the secretory surface of parietal cells. By blocking this final step of acid secretion, it markedly reduces both basal and stimulated gastric acidity, allowing ulcer healing and symptom control in acid‑related disorders.

Side Effects

Lansoprazole is generally well tolerated, but adverse reactions can occur.

Common Side Effects

  • Headache: mild to moderate intensity.
  • Diarrhoea: transient loose stools.
  • Nausea: occasional upset stomach.
  • Abdominal pain: mild discomfort.
  • Flatulence: increased gas.
  • Constipation: reduced bowel movements.

Serious or Rare Side Effects

  • Clostridioides difficile infection: severe colitis.
  • Severe allergic reactions: rash, angioedema, anaphylaxis.
  • Hepatic injury: elevated liver enzymes, jaundice.
  • Stevens‑Johnson syndrome/toxic epidermal necrolysis: severe skin reactions.
  • Hypomagnesemia: low serum magnesium with prolonged use.
  • Bone fracture risk: increased incidence with long‑term therapy.

Precautions & Warnings

When prescribing Lansoprazole, consider the following precautions.

  • Renal function assessment: adjust use in severe renal impairment.
  • Long‑term therapy review: limit duration unless clinically indicated.
  • Magnesium monitoring: check levels during extended treatment.
  • Hepatic impairment: use with caution in moderate liver disease.
  • Elderly patients: monitor for increased susceptibility to adverse effects.
  • Store at below 25°C: keep in the original pack, protect from moisture.

Avoid Interactions

Lansoprazole may interact with several medications, affecting their efficacy or safety.

Major Interactions (Avoid)

  • Clopidogrel: reduced antiplatelet activity.
  • Atorvastatin: increased plasma concentration, risk of myopathy.
  • Methotrexate: heightened toxicity due to reduced clearance.

Moderate Interactions (Monitor Closely)

  • Warfarin: variable INR, monitor coagulation.
  • Digoxin: increased serum levels, watch for toxicity.
  • Diazepam: enhanced absorption, may increase sedation.

Frequently Asked Questions

Ogast, containing the active ingredient Lansoprazole, is used to treat acid‑related gastrointestinal conditions such as gastro‑oesophageal reflux disease, erosive esophagitis, peptic ulcer disease and as part of combination therapy for Helicobacter pylori eradication. By reducing gastric acid secretion, it helps relieve symptoms and promotes healing of the affected mucosa.

Lansoprazole belongs to the proton pump inhibitor class. It binds covalently to the H+/K+‑ATPase enzyme on the secretory surface of gastric parietal cells, irreversibly blocking the final step of acid production. This inhibition lowers both basal and stimulated gastric acidity, providing a sustained reduction in stomach acid levels.

The specific dose of Ogast is determined by the prescribing healthcare professional based on the patient’s condition, severity, and response to therapy. Dosage may vary for short‑term versus long‑term treatment, and the prescriber will provide individualized instructions.

Lansoprazole is classified as Pregnancy Category B in many regions, indicating no evidence of risk in animal studies but insufficient human data. It should only be used during pregnancy or lactation if clearly needed and after a risk‑benefit assessment by the prescriber. Breastfeeding mothers should discuss potential exposure with their healthcare provider.

To request Ogast, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, confirming trade or institutional credentials before providing pricing, availability, shipping details (including any cold‑chain requirements) and necessary import documentation.

Ogast (Lansoprazole) shares the same mechanism of action as other PPIs such as omeprazole, esomeprazole and pantoprazole, providing comparable acid suppression. Differences may lie in pharmacokinetic profiles, drug‑interaction potential, and individual patient tolerance. Choice of PPI often depends on clinician preference, patient response, and specific drug‑interaction considerations.

Ogast tablets should be stored at temperatures below 25 °C (77 °F). Keep them in the original packaging to protect from moisture and light, and store in a dry place away from direct heat. Do not refrigerate or freeze the product.

Ogast tablets are taken orally, usually once daily before a meal, preferably in the morning. The tablet should be swallowed whole with a glass of water and not crushed or chewed, unless otherwise directed by the prescriber.

Serious risks, though uncommon, include Clostridioides difficile‑associated diarrhea, severe allergic reactions such as anaphylaxis, hepatic injury, hypomagnesemia with long‑term use, and rare skin reactions like Stevens‑Johnson syndrome. Patients should be advised to seek immediate medical attention if they experience severe rash, persistent diarrhea, jaundice, or muscle weakness.

Patients with known hypersensitivity to Lansoprazole or any component of the tablet should not use Ogast. Caution is advised for individuals with severe liver disease, those taking medications that have major interactions (e.g., clopidogrel), and patients with a history of osteoporosis or fractures when considering long‑term therapy.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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