Okaltus (Dextromethorphan Hydrobromide, Guaifenesin)

Okaltus combines dextromethorphan and guaifenesin to address cough and mucus clearance in the respiratory system.

• Cough associated with the common cold: reduces the urge to cough and improves comfort.
• Acute bronchitis: helps control coughing episodes and facilitates expectoration.
• Upper respiratory tract infections: eases cough and aids mucus clearance.
• Chronic obstructive pulmonary disease (COPD) exacerbations: supports symptomatic relief of cough when used as part of a broader treatment plan.

• Dextromethorphan acts as a sigma‑1 receptor agonist and centrally suppresses the cough reflex in the medullary cough center, while guaifenesin reduces the viscosity of bronchial secretions, promoting mucociliary clearance. Together they provide symptomatic relief of cough and facilitate expectoration without directly treating the underlying infection.

Okaltus may cause a range of adverse reactions, most of which are mild and transient.

Common Side Effects

• Drowsiness: mild sedation.
• Nausea: occasional upset stomach.
• Dizziness: light‑headed feeling.
• Dry mouth: reduced salivation.
• Upper respiratory tract irritation: mild throat discomfort.

Serious or Rare Side Effects

• Allergic reaction: rash, itching, swelling, or difficulty breathing.
• Hallucinations or altered perception: rare central nervous system effects.
• Severe dizziness or loss of coordination.
• Persistent vomiting.
• Cardiac arrhythmias in susceptible individuals.

When using Okaltus, consider the following safety measures:

• Avoid alcohol: increases risk of sedation and respiratory depression.
• Do not operate machinery: potential drowsiness may impair coordination.
• Monitor in patients with liver disease: hepatic metabolism may be altered.
• Use caution in asthma or COPD patients: may affect airway reactivity.
• Store at below 25°C: keep in the original pack, protect from moisture.

Okaltus can interact with several medicines, requiring attention to avoid reduced efficacy or increased toxicity.

Major Interactions (Avoid)

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