Okitask (Ketoprofen Lysine)

Ketoprofen lysine is an NSAID that reduces inflammation and pain in several musculoskeletal conditions.

• Rheumatoid arthritis: helps reduce joint pain, swelling and stiffness.
• Osteoarthritis: alleviates chronic joint discomfort and improves mobility.
• Acute musculoskeletal injury: provides short‑term pain relief and decreases inflammation.
• Post‑operative pain: assists in managing pain after surgical procedures.
• Dysmenorrhea: lessens menstrual cramps and associated pelvic pain.

• Ketoprofen lysine works by reversibly inhibiting cyclo‑oxygenase (COX‑1 and COX‑2) enzymes, which decreases the synthesis of prostaglandins that mediate inflammation, pain and fever. This reduction in prostaglandin production lessens peripheral sensitisation of nerve endings and provides anti‑inflammatory and analgesic effects.

Ketoprofen lysine may cause a range of adverse reactions, most of which are mild and reversible.

Common Side Effects

• Gastrointestinal discomfort: nausea, dyspepsia or heartburn.
• Headache: mild to moderate intensity.
• Dizziness: transient sensations of light‑headedness.
• Skin rash: mild erythema or itching.
• Elevated liver enzymes: mild, asymptomatic changes in blood tests.

Serious or Rare Side Effects

• Peptic ulcer disease or gastrointestinal bleeding.
• Severe skin reactions such as Stevens‑Johnson syndrome.
• Renal impairment or acute kidney injury.
• Hepatotoxicity: significant liver enzyme elevation or hepatitis.
• Anaphylaxis: rapid onset of allergic reaction with airway compromise.

When prescribing Ketoprofen lysine, clinicians should consider several safety aspects.

• Assess renal function: evaluate baseline kidney health before initiating therapy.
• Monitor hepatic status: check liver enzymes in patients with existing liver disease.
• Evaluate cardiovascular risk: use cautiously in patients with hypertension or heart disease.
• Avoid concurrent NSAIDs: reduce risk of gastrointestinal and renal adverse events.
• Counsel on alcohol use: limit intake to minimise gastric irritation.
• Store at below 25°C: keep in the original packaging, protect from moisture and direct sunlight.

Ketoprofen lysine can interact with a variety of medicines, altering efficacy or safety.

Major Interactions (Avoid)

• Anticoagulants (e.g., warfarin): increased bleeding risk.
• Selective serotonin reuptake inhibitors (SSRIs): heightened gastrointestinal bleeding risk.
• ACE inhibitors/ARBs: may reduce renal perfusion and function.

Moderate Interactions (Monitor Closely)

• Diuretics: potential for reduced effectiveness and electrolyte imbalance.
• Corticosteroids: additive risk of gastrointestinal ulceration.
• Lithium: possible increase in lithium serum levels.