Okitask (Ketoprofen Lysine)

Ketoprofen lysine is an NSAID that reduces inflammation and pain in several musculoskeletal conditions.

• Osteoarthritis: alleviates joint pain and improves mobility.
• Rheumatoid arthritis: decreases inflammation and joint swelling.
• Acute musculoskeletal injury: provides short‑term relief of pain and inflammation.
• Post‑operative pain: helps control pain after surgical procedures.
• Dysmenorrhea: reduces menstrual‑related pelvic pain.

• Ketoprofen lysine exerts its anti‑inflammatory and analgesic effects by reversibly inhibiting cyclooxygenase (COX‑1 and COX‑2) enzymes, which reduces the synthesis of prostaglandins involved in pain signalling, inflammation and fever. This inhibition decreases peripheral sensitisation of nociceptors and limits the inflammatory response.

Ketoprofen lysine may cause a range of adverse reactions, most of which are mild to moderate and resolve after discontinuation.

Common Side Effects

• Gastrointestinal discomfort, such as dyspepsia or heartburn.
• Nausea or vomiting.
• Headache.
• Dizziness.
• Mild skin rash.
• Elevated liver enzymes.

Serious or Rare Side Effects

• Peptic ulcer disease or gastrointestinal bleeding.
• Severe skin reactions such as Stevens‑Johnson syndrome.
• Renal impairment or acute kidney injury.
• Hepatotoxicity with jaundice.
• Anaphylactic or severe allergic reactions.
• Cardiovascular events such as myocardial infarction or stroke.

When prescribing Ketoprofen lysine, clinicians should consider several safety aspects to minimise risk.

• Gastrointestinal risk: assess history of ulcers or bleeding before use.
• Cardiovascular caution: avoid in patients with uncontrolled hypertension or recent thrombotic events.
• Renal function: monitor kidney parameters in patients with pre‑existing renal disease.
• Hepatic monitoring: check liver function tests during prolonged therapy.
• Drug interactions: review concomitant NSAIDs, anticoagulants and antihypertensives.
• Store at ambient temperature: keep in the original container, protect from moisture and direct sunlight.

Ketoprofen lysine can interact with several drug classes, altering efficacy or safety.

Major Interactions (Avoid)

• Anticoagulants (e.g., warfarin): increased risk of serious bleeding.
• Other NSAIDs or COX‑2 inhibitors: heightened gastrointestinal toxicity.
• Corticosteroids: additive risk of ulceration and bleeding.

Moderate Interactions (Monitor Closely)

• ACE inhibitors or ARBs: may reduce antihypertensive effect and impair renal function.
• Diuretics (especially thiazides): potential for reduced renal clearance.
• Lithium: NSAIDs can increase lithium serum concentrations.
• Methotrexate: decreased renal elimination may raise toxicity risk.