Okitask (Ketoprofen Lysine)

Ketoprofen lysine is an NSAID that reduces inflammation and pain in several musculoskeletal and inflammatory disorders.

• Rheumatoid arthritis: helps reduce joint swelling, pain and stiffness.
• Osteoarthritis: provides symptomatic relief of joint pain and improves mobility.
• Acute musculoskeletal pain: alleviates pain from sprains, strains and soft‑tissue injuries.
• Post‑operative pain: supports short‑term pain control after surgical procedures.
• Dysmenorrhea: reduces menstrual‑related pelvic pain.

• Ketoprofen lysine exerts its anti‑inflammatory and analgesic actions by reversibly inhibiting cyclooxygenase‑1 and cyclooxygenine‑2 (COX‑1 and COX‑2) enzymes, which decreases prostaglandin synthesis at sites of inflammation. The reduced prostaglandin levels lower vascular permeability, pain‑signal transmission, and leukocyte activation, providing relief from pain and swelling.

Ketoprofen lysine may cause a range of adverse reactions, most of which are dose‑dependent and reversible.

Common Side Effects

• Gastrointestinal discomfort: nausea, dyspepsia or abdominal pain.
• Headache: mild to moderate intensity.
• Dizziness or light‑headedness.
• Skin rash or mild itching.
• Elevated liver enzymes.

Serious or Rare Side Effects

• Peptic ulcer disease or gastrointestinal bleeding.
• Severe skin reactions such as Stevens‑Johnson syndrome.
• Hepatotoxicity or marked liver injury.
• Renal impairment or acute kidney injury.
• Anaphylactic or severe allergic reactions.

When prescribing Ketoprofen lysine, clinicians should consider several safety aspects to minimise risk.

• Assess renal function: evaluate baseline creatinine and eGFR before initiating therapy.
• Monitor gastrointestinal risk: avoid in patients with a history of ulcers or bleeding.
• Evaluate cardiovascular risk: use cautiously in individuals with hypertension or heart disease.
• Review concomitant medications: check for other NSAIDs or anticoagulants.
• Pregnancy and lactation: avoid if possible; use only when benefits outweigh risks.
• Store at ambient temperature: keep in the original packaging, protect from moisture and light.

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