Product image of Olanzapina Alter (Olanzapine) supplied by GNH India

Olanzapina Alter

Active Ingredient:
Olanzapine
Origin:
EU

Olanzapina Alter (Olanzapine)

Olanzapine, the active ingredient in Olanzapina Alter, is an atypical antipsychotic presented as a tablet for oral use. It is used to manage symptoms of schizophrenia and bipolar disorder in adults and adolescents.

GNH India supplies Olanzapina Alter as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Laboratorios Alter, S.A.

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Indications & Clinical Uses

Olanzapine is an atypical antipsychotic that acts on dopamine and serotonin pathways to treat serious mental health conditions.

  • Schizophrenia: Improves psychotic symptoms such as delusions, hallucinations and thought disorder.
  • Bipolar I disorder (manic episodes): Reduces mania‑related elevated mood, energy and activity.
  • Bipolar disorder maintenance: Helps prevent recurrence of mood episodes.
  • Schizoaffective disorder: Alleviates combined mood and psychotic symptoms.
  • Psychotic depression: Augments antidepressant therapy to address psychotic features.

How It Works

  • Olanzapine exerts its antipsychotic effect by antagonising dopamine D2 receptors and serotonin 5‑HT2A receptors, with additional activity at histamine H1, muscarinic and adrenergic receptors. This receptor profile modulates neurotransmission in cortical and limbic circuits, reducing psychotic and mood‑stabilising effects.

Side Effects

Olanzapine may cause a range of adverse reactions that vary in frequency and severity.

Common Side Effects

  • Weight gain: Increased appetite and caloric intake.
  • Sedation: Drowsiness or feeling of being slowed down.
  • Metabolic changes: Elevated blood glucose and lipid levels.
  • Dry mouth: Reduced salivation.
  • Constipation: Decreased bowel motility.
  • Orthostatic hypotension: Light‑headedness on standing.

Serious or Rare Side Effects

  • Neuroleptic malignant syndrome: Potentially life‑threatening reaction with fever and muscle rigidity.
  • Tardive dyskinesia: Involuntary, repetitive movements, often of the face.
  • Hyperglycaemia/diabetes mellitus: Marked increase in blood sugar.
  • Seizures: New‑onset convulsive episodes.
  • Agranulocytosis: Severe reduction in white‑blood cells.
  • Elevated prolactin: Hormonal imbalance causing menstrual disturbances.

Precautions & Warnings

When prescribing Olanzapina Alter, clinicians should consider several safety aspects.

  • Monitor metabolic parameters: Regularly check weight, fasting glucose and lipid profile.
  • Assess for movement disorders: Watch for early signs of tardive dyskinesia.
  • Evaluate cardiovascular status: Check blood pressure and pulse regularly.
  • Review hepatic and renal function: Adjust if significant impairment exists.
  • Pregnancy and lactation: Use only if benefits outweigh risks.
  • Store at ambient temperature: Keep below 25°C in the original packaging, protected from moisture.

Avoid Interactions

Olanzapine can interact with other medicines, altering its effectiveness or safety profile.

Major Interactions (Avoid)

  • Strong CYP1A2 inhibitors (e.g., fluvoxamine): Increase olanzapine plasma levels.
  • CNS depressants: Additive sedation and respiratory depression.
  • Anticholinergic agents: Heightened anticholinergic burden.

Moderate Interactions (Monitor Closely)

  • CYP3A4 inducers (e.g., carbamazepine): Reduce olanzapine concentrations.
  • Smoking: Induces CYP1A2, potentially lowering drug exposure.
  • Antihypertensive drugs: May enhance hypotensive effects.

Frequently Asked Questions

Olanzapina Alter contains olanzapine, an atypical antipsychotic that is prescribed to treat schizophrenia, bipolar I disorder (including manic episodes), and related psychotic conditions. It helps reduce hallucinations, delusions, mood swings and other symptoms associated with these disorders.

Olanzapine works by blocking dopamine D2 receptors and serotonin 5‑HT2A receptors in the brain, which moderates neurotransmitter activity in pathways that influence mood, perception and thought processes. This receptor antagonism reduces psychotic and manic symptoms.

The appropriate dose of Olanzapina Alter is determined by the prescribing clinician based on the patient’s condition, age, response and tolerability. Dosage adjustments are made during treatment to achieve optimal therapeutic effect while minimizing side effects.

Olanzapine is classified as pregnancy category C; it should be used only if the potential benefit justifies the potential risk to the fetus. It is excreted in breast‑milk, so breastfeeding mothers should discuss risks and alternatives with their healthcare provider.

To place an order, submit an enquiry on the product page at gnhindia.com with the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Compared with first‑generation antipsychotics, olanzapine has a lower risk of extrapyramidal symptoms but a higher propensity for metabolic side effects such as weight gain and glucose elevation. Within atypical agents, its efficacy is similar to risperidone and quetiapine, while its side‑effect profile differs.

Olanzapina Alter tablets should be stored at ambient temperature, below 25 °C, in the original container to protect them from moisture and light. Keep the product out of reach of children.

Olanzapina Alter is supplied as oral tablets that are taken by mouth, usually once daily with or without food. The tablet should be swallowed whole with water and not crushed or chewed unless specifically instructed by a healthcare professional.

Serious risks include neuroleptic malignant syndrome, severe hyperglycaemia or new‑onset diabetes, tardive dyskinesia, and significant weight gain that can increase cardiovascular risk. Patients should be monitored regularly for these conditions.

Olanzapina Alter is contraindicated in individuals with known hypersensitivity to olanzapine or any of its excipients. Caution is also advised for patients with uncontrolled diabetes, severe cardiovascular disease, or a history of neuroleptic malignant syndrome.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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