Product image of Olanzapina Doc (Olanzapine) supplied by GNH India

Olanzapina Doc

Active Ingredient:
Olanzapine
Origin:
EU

Olanzapina Doc (Olanzapine)

Olanzapine, the active ingredient in Olanzapina Doc, is an atypical antipsychotic presented as a tablet for oral use. It is used to treat schizophrenia and bipolar disorder in adults, helping to control psychotic symptoms and mood swings.
GNH India supplies Olanzapina Doc as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Doc Generici S.R.L.

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Indications & Clinical Uses

Olanzapine is an atypical antipsychotic that modulates dopamine and serotonin pathways, and is indicated for the following conditions:

  • Schizophrenia: reduces hallucinations, delusions and other psychotic symptoms.
  • Bipolar I disorder (manic episodes): stabilises mood and decreases manic symptoms.
  • Acute agitation associated with schizophrenia or bipolar disorder: provides rapid calming effect.

How It Works

  • Olanzapine exerts its antipsychotic effect primarily by antagonising dopamine D2 receptors and serotonin 5‑HT2A receptors in the central nervous system. It also binds to histamine H1, muscarinic M1‑M5 and α1‑adrenergic receptors, influencing neurotransmitter activity and contributing to both therapeutic benefits and side‑effect profiles.

Side Effects

Olanzapine may cause a range of adverse reactions.

Common Side Effects

  • Weight gain: increased appetite and body mass.
  • Sedation: drowsiness or fatigue.
  • Dry mouth: reduced salivation.
  • Constipation: slowed gastrointestinal motility.
  • Dizziness: light‑headedness, especially on standing.
  • Increased appetite: may contribute to weight gain.

Serious or Rare Side Effects

  • Hyperglycaemia/diabetes mellitus: elevated blood glucose levels.
  • Neuroleptic malignant syndrome: rare but life‑threatening reaction.
  • Tardive dyskinesia: involuntary movements with long‑term use.
  • Agranulocytosis: severe reduction in white blood cells.
  • Severe orthostatic hypotension: marked blood pressure drop on standing.
  • Myocarditis: inflammation of the heart muscle, very rare.

Precautions & Warnings

Before initiating therapy, consider the following precautions:

  • Pregnancy: use only if potential benefit justifies the potential risk to the fetus.
  • Lactation: olanzapine is excreted in breast milk; weigh benefits against possible infant exposure.
  • Elderly patients with dementia: increased risk of mortality; avoid unless clearly indicated.
  • Metabolic monitoring: regularly assess weight, glucose, and lipid levels.
  • Discontinuation: taper dose gradually to minimise withdrawal or rebound symptoms.
  • Store at room temperature: keep in the original container, protect from moisture and light.

Avoid Interactions

Olanzapine can interact with several medicines.

Major Interactions (Avoid)

  • CYP1A2 inhibitors (e.g., fluvoxamine): may raise olanzapine plasma concentrations.
  • CNS depressants (e.g., benzodiazepines, alcohol): additive sedation and respiratory depression.
  • Strong anticholinergic agents: may exacerbate anticholinergic side effects.

Moderate Interactions (Monitor Closely)

  • CYP1A2 inducers (e.g., smoking, carbamazepine): may reduce olanzapine effectiveness.
  • Other antipsychotics: increased risk of QT prolongation and cardiac effects.
  • Lithium: monitor for neurotoxicity when used together.

Frequently Asked Questions

Olanzapina Doc contains olanzapine, an atypical antipsychotic indicated for the treatment of schizophrenia and bipolar I disorder in adults. It helps control psychotic symptoms such as hallucinations and delusions, and stabilises mood during manic episodes. The medication may also be prescribed for acute agitation associated with these conditions.

Olanzapine works by blocking dopamine D2 receptors and serotonin 5‑HT2A receptors in the brain, which reduces the over‑activity of these neurotransmitters that contribute to psychosis and mood instability. Its additional affinity for histamine, muscarinic and adrenergic receptors influences sedation, metabolic effects, and other clinical outcomes.

The exact dose of Olanzapina Doc is determined by the prescribing clinician based on the patient’s condition, response, and tolerability. Typical adult dosing ranges are established in clinical guidelines, but the prescriber will individualise the regimen and may adjust it over time.

Safety data for olanzapine during pregnancy and lactation are limited. Use is generally reserved for situations where the therapeutic benefit outweighs potential risks to the fetus or infant. Women who are pregnant, planning pregnancy, or breastfeeding should discuss risks and alternatives with their healthcare provider.

To order Olanzapina Doc, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India supplies hospitals, pharmacies and procurement teams worldwide, and will request verification of trade or institutional credentials. The team then replies with pricing, availability, shipping details (including any cold‑chain requirements) and the necessary import documentation.

Olanzapine is distinguished by its strong affinity for both dopamine and serotonin receptors, offering efficacy in treating both psychosis and mood symptoms. Compared with agents such as risperidone, olanzapine often has a higher propensity for metabolic side effects like weight gain and glucose elevation, while risperidone may carry a greater risk of prolactin elevation. Choice depends on individual patient profiles and tolerability.

Olanzapina Doc should be stored at room temperature, below 25 °C, in its original packaging to protect it from moisture and light. Keep the product out of reach of children and avoid storing it in humid or excessively hot environments.

Olanzapina Doc is supplied as oral tablets that are taken by mouth. Patients should swallow the tablet whole with water and follow the dosing schedule prescribed by their clinician. It is usually taken once daily, but the exact timing may vary based on individual treatment plans.

Serious risks include the development of hyperglycaemia or diabetes, neuroleptic malignant syndrome, tardive dyskinesia with long‑term use, severe orthostatic hypotension, and rare cases of agranulocytosis or myocarditis. Patients should be monitored regularly for metabolic changes, movement disorders, and any signs of infection or cardiac issues.

Olanzapina Doc is contraindicated in patients with known hypersensitivity to olanzapine or any of its excipients. It should be used with caution in individuals with severe hepatic impairment, uncontrolled diabetes, or a history of neuroleptic malignant syndrome. Elderly patients with dementia-related psychosis have an increased risk of mortality and should generally avoid its use.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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